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High mortality and mechanical ventilation in COVID-19-associated pulmonary aspergillosis: insights from a two-center retrospective cohort study
BACKGROUND: Studies on COVID-19-associated pulmonary aspergillosis (CAPA) have raised concerns regarding its high mortality rates. This study aims to assess the mortality of CAPA caused by Alpha and Omicron variants among intensive care unit (ICU) patients in China. METHODS: We enrolled 236 ICU…
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EBUS-TBNA needle rinse fluid: a superior specimen for the molecular diagnosis of intrathoracic lymph node tuberculosis
OBJECTIVES: To evaluate EBUS-TBNA needle rinse fluid versus biopsy tissue for molecular diagnosis of intrathoracic lymph node tuberculosis (TB). METHODS: Retrospective analysis of 63 patients with intrathoracic lymph node TB undergoing EBUS-TBNA (2018–2024). Rinse fluid and biopsy tissue were…
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Comparison of rTMS and dTMS in TRD: evidence gaps, cost-effectiveness, and ethical priorities
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Artikel Jurnal Teks lengkap
Comparison between metatranscriptomics and viral metagenomics, 16S, and host transcriptomics for comprehensive profiling of the respiratory microbiome and host response
INTRODUCTION: Omics-based studies focusing on a single kingdom, such as bacterial 16S gene sequencing, viral metagenomics, and human mRNA sequencing, are commonly used to explore the microbiome and its association with host responses. But combining these approaches is often expensive and…
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The neuromechanics of the soleus for fall prevention in aging
Falls are a leading cause of injury-related hospitalization, morbidity, and mortality in older adults, with impaired postural control serving as a key predictor of fall risk. The triceps surae, and particularly the soleus, plays a central role in maintaining upright stance by generating continuous…
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Root exudate monosaccharides modulate the pathogenicity of Ralstonia pseudosolanacearum
The Ralstonia solanacearum species complex (RSSC) is a devastating soil-borne pathogen that causes bacterial wilt in solanaceous crops. However, the response of RSSC to monosaccharides—key components of root exudates released into the rhizosphere—remains unclear. We supplemented culture media with…
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Artikel Jurnal Teks lengkap
Biomechanical insights into carbon plate geometry in running shoes in male runners: implications for sprint performance and ankle stability
To date, limited evidence exists on how carbon plate geometry influences sprint biomechanics. This study investigated the biomechanical effects of different carbon plate configurations in running shoes on sprint performance and lower-limb stability. Forty trained male sprinters performed submaximal…
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T1- and diffusion tensor-based fractal dimension of white and grey matter in multiple sclerosis
INTRODUCTION: Multiple sclerosis (MS) changes brain microstructure even at early disease stages, with changes detectable in normal-appearing white matter (NAWM) and grey matter (GM). Diffusion tensor imaging (DTI) is sensitive to such alterations, while fractal dimension (FD) provides complementary…
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Assessing the correlation between STAR health risk forecasts with actual health emergencies in West and Central Africa: a three-year analysis
INTRODUCTION: This study evaluates the Strategic Tool for Assessing Risks (STAR), developed by the World Health Organization (WHO), for its effectiveness in predicting public health emergencies across West and Central Africa during the period 2022–2024. STAR applies a composite risk scoring system…
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Bioactives and exercise synergize to modulate AMPK and inflammation
AMP-activated protein kinase (AMPK) regulates energy homeostasis and immune responses, making it a key target for immunometabolic disorders like obesity, insulin resistance, and neurodegenerative diseases. This review explores the synergistic effects of plant-derived bioactives (e.g., quercetin…
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Artikel Jurnal Teks lengkap
Efficacy and safety of PARP inhibitors in advanced or recurrent endometrial cancer: a systematic review and meta-analysis
OBJECTIVE: Several clinical trials have explored the efficacy and safety of Poly (ADP-ribose) polymerase (PARP) inhibitors in endometrial cancer (EC). However, evidence supporting PARP inhibitors alone or in combination with other medications in advanced or recurrent EC remains limited. METHODS: We…
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Establishment and characterization of a human juvenile bone marrow-derived mesenchymal stem/stromal cell line under advanced culture conditions for osteogenic differentiation
Human mesenchymal stem/stromal cells (MSC) from juvenile donors (juvMSC) are crucial for studying bone development and for modeling pediatric skeletal diseases. However, the limited availability of these cells and the lack of physiologically relevant in vitro models hinder preclinical research. To…
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Effects of preoperative nutritional support combined with esketamine on recovery and analgesia after thoracoscopic radical resection of lung cancer in elderly patients
AIM: This study aims to explore the effects of preoperative nutritional support combined with esketamine on recovery and postoperative pain management in elderly patients undergoing thoracoscopic radical resection for lung cancer. METHODS: A total of 165 elderly patients with lung cancer who…
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Combining triglyceride glucose-body mass index and high-sensitivity C-reactive protein to predict cardiovascular disease: results from a national cohort and a clinical verified cohort
BACKGROUND: Accumulating evidence highlights a strong association between insulin resistance (IR) and inflammation in the context of cardiovascular disease (CVD). However, the combined impact of both factors on the risk of developing CVD remains underexplored. This study aims to investigate how…
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From believing to behaving: Unpacking teacher emotion as the mediator between information literacy self-efficacy and information-empowered teaching engagement
INTRODUCTION: In the era of artificial intelligence, information literacy is a crucial skill for teachers, enabling the effective integration of technology into pedagogy. This study examines the psychological factors influencing the information-empowered teaching engagement of university English…
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Differential gut microbiome composition in three-spined stickleback populations with contrasting levels of mercury accumulation
INTRODUCTION: Environmental micropollutants and other anthropogenic xenobiotics are potential drivers behind compositional shifts and functional dysregulation of gut microbial communities. Mercury and many of its compounds are highly toxic and ubiquitous environmental pollutants that pose a risk…
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CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice
INTRODUCTION: Alzheimer’s disease (AD) is neurodegenerative disorder characterized by chronic inflammation in the brain. Chitinase-3-like 1 (CHI3L1), a secreted glycoprotein that is upregulated in a variety of diseases with chronic inflammation, represents a promising target for AD. Here, we…
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Estimating the adverse selection and moral hazard in Urban and Rural Resident Basic Medical Insurance of China: a semi-parametric estimation approach
INTRODUCTION: This study investigated the causes of excessive medical resources consumption, by disentangling and estimating the adverse selection and moral hazard within China’s Urban and Rural Resident Basic Medical Insurance (URRBMI), with the aim of proposing targeted solutions to this issue…
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Unlocking circular bioeconomy potential of termite-gut yeasts: dual bioremediation and biodiesel production
Lignin-derived aromatics and synthetic azo dyes are among the most persistent and toxic pollutants released by textile processing, petrochemical industries, pulp-and-paper manufacturing, and agricultural waste streams. Their structural complexity, chemical stability, and resistance to degradation…
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A novel effect of bevacizumab in reducing characteristic pigmentation in Peutz–Jeghers syndrome: a case report and literature review
Peutz–Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation (e.g., perioral melanotic macules) and gastrointestinal hamartomatous polyps, with heightened cancer susceptibility. This report describes a 34-year-old Han Chinese ethnicity woman with…
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