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Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease
AMP-activated protein kinase (AMPK) is capable of regulating cellular energy homeostasis and mitochondrial homeostasis. The activation of AMPK can ameliorate metabolic-associated fatty liver disease (MAFLD). An increasing number of studies have demonstrated that AMPK is a crucial enzyme in the…
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Parental concerns correspond to earliest age of autism diagnosis in increased likelihood infant cohort
Autism spectrum disorder (ASD) encompasses a set of behavioural features with a diverse range of presentations, challenges, and trajectories. Previous research has demonstrated how behavioural and developmental markers can differentiate autistic from non-autistic children as early as the first year…
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Aligned piezoelectric fibrous scaffolds for prevention of traumatic neuroma formation
PURPOSE: Traumatic neuroma, a painful complication of peripheral nerve injury, arises from disorganized axonal regeneration and chronic inflammation. Existing treatments provide limited relief. This study aimed to evaluate the therapeutic potential of aligned piezoelectric poly (L-lactide) (PLLA)…
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Swearing enhances manual dexterity
Swearing, or the use of taboo language, has been linked to increased psychological flow, self-confidence, and state disinhibition, raising the possibility that it may function as a psychological warm-up to enhance fine motor skills. This study investigated whether repeating a swear word, compared…
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Therapeutic antibody delivery: vector tools to boost efficacy and affordability
Antibody (Ab)-based therapeutics have become powerful tools across diverse disease areas, with advances in bioengineering giving rise to next−generation molecules designed to outperform conventional Abs. Yet, large-scale production and purification of such complex proteins remain costly and can…
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Pharmacovigilance insights: safety profiles of antifungal agents for invasive aspergillosis
BACKGROUND: Invasive aspergillosis (IA) poses significant mortality risks, particularly in immunocompromised patients. The safety profiles of FDA-approved antifungal agents, triazoles (Voriconazole, Posaconazole, Isavuconazole), polyenes (Amphotericin B), and echinocandins (Caspofungin), are not…
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Influence of vertical growth pattern on masseter muscle morphology: evidence from cephalometric and ultrasound assessment in eighteen growing subjects
INTRODUCTION: The relationship between vertical facial dimensions and morphological-functional features of the masseter muscle in growing patients is of increasing interest in orthodontics. Understanding these correlations may enhance diagnostic accuracy and guide treatment planning, particularly…
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Binding of IgA1 and surface-expressed collagen-binding protein of Streptococcus mutans contributes to IgA nephropathy pathogenesis
BACKGROUND: The present study was conducted to examine the interaction between collagen-binding protein (Cnm) of Streptococcus mutans and immunoglobulin (IgA) to clarify the possible involvement in IgA nephropathy (IgAN) development. METHODS: The binding of Cnm to human immunoglobulins was examined…
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Artikel Jurnal Teks lengkap
Editorial: Current advances in the understanding and management of pelvic organ prolapse
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Artikel Jurnal Teks lengkap
Machine learning-based prediction model for 30-day readmission risk in elderly patients with type 2 diabetes mellitus and heart failure: a retrospective cohort study with SHAP interpretability analysis
OBJECTIVE: Among elderly populations with concurrent type 2 diabetes mellitus (T2DM) and heart failure (HF), 30-day hospital readmission rates range 10%–25%. Conventional risk evaluation instruments show restricted predictive performance (AUC
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Medication use in Poland for children and adolescents with neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data
BACKGROUND: The pandemic profoundly disrupted healthcare and education systems, potentially affecting the pharmacological management of neurodevelopmental disorders (NDDs) in children and adolescents. OBJECTIVE: To examine national trends in psychotropic drug dispensing among pediatric patients…
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Five differentially expressed proteins identified to serve as potential blood biomarkers for schizophrenia screening based on proteomics
INTRODUCTION: Schizophrenia is a multifactorial neuropsychiatric disorder characterized by a wide range of debilitating symptoms and relatively poor clinical outcome, bringing a huge burden of disease. However, the underlying pathological mechanism of this disease remains unclear. We aimed to use…
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Comparative safety profiles of spironolactone, eplerenone, and finerenone: a pharmacovigilance study based on FAERS data from 2004 to 2024
BACKGROUND: Spironolactone, eplerenone, and finerenone are three commonly used mineralocorticoid receptor antagonists (MRAs) with cardioprotective and renoprotective effects. However, comparative real-world safety evaluations remain limited. This study aimed to assess and compare the adverse event…
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Pre‑partum blood leukocyte profiles distinguish gestational inflammatory stages that predict birth‑related adverse outcomes
INTRODUCTION: Pregnancy is a physiological process accompanied by immuno-dynamic changes (inflammatory stages) that could influence or predict pregnancy outcomes. However, overlapping data intervals among biologically distinct conditions may hinder such differentiation. Here, a retrospective…
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Glycan masking in immunogen design: computational and experimental methods
Epitope-focused vaccine design aims to improve upon existing immunization strategies by eliciting immune responses against specific epitopes targeted by known therapeutic antibodies. One of the techniques in epitope-focused immunogen design is glycan masking, in which sugars are used to hide…
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Ethnic-specific discrimination: focus group findings of Korean American emerging adults
INTRODUCTION: Disaggregating the Asian American racial category is crucial to understanding ethnic differences in discrimination. However, few studies have qualitatively explored perceptions of whether ethnic discrimination differs from racial discrimination. METHODS: We conducted three focus…
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Data mining historical Chinese medical recipe collections and nuclear receptor profiling identify plant fractions that modulate glucocorticoid receptor activity
OBJECTIVE: Glucocorticoids (GCs) play a prominent role in the management of chronic inflammatory diseases like rheumatoid arthritis and psoriatic arthritis, but their use is associated with various adverse effects. The therapeutic and adverse effects of GCs can be partly explained by modes of…
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Artikel Jurnal Teks lengkap
Case Report: Giant uterine broad ligament fibroid
Giant uterine fibroids that arise shortly after cesarean section are a rare and distinctive clinical entity. In this research, a retrospective analysis was carried out on the clinical data of a particular patient with such giant uterine fibroids who was admitted to Hangzhou Obstetrics and…
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Artikel Jurnal Teks lengkap
Development and validation of a nomogram for predicting atrial fibrillation after percutaneous coronary intervention in patients with acute myocardial infarction
BACKGROUND: Atrial fibrillation (AF) is a frequent complication in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI), contributing to adverse outcomes. Early identification of individuals at high risk for post-PCI AF is crucial for tailored…
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