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Artikel Jurnal Teks lengkap
Water deficit and salinity stresses modulate growth, physiology, and phytochemical composition of Lavandula coronopifolia Poir. grown in pots under controlled conditions
Lavandula coronopifolia Poir. is a medicinal evergreen shrub, wildly distributed in rocky and arid environments. It belongs to the Lamiaceae family, known by the large array of bioactive compounds it contains. Drought and salinity present major threats in arid zones and severely penalize the…
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Artikel Jurnal Teks lengkap
Editorial: Deciphering cell-cell interactions in triple-negative breast cancer
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Artikel Jurnal Teks lengkap
Higher risk of postpartum phase transition to immune-active among HBeAg-positive pregnant women with indeterminate phase
BACKGROUND: Understanding the natural history of hepatitis B virus (HBV) infection helps determine the optimal timing of antiviral therapy. However, a gap exists in the literature regarding the dynamics of the natural history of HBV infection in pregnant women with chronic hepatitis B (CHB). This…
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Artikel Jurnal Teks lengkap
Determinants of contraceptive use and intention to use among youth 15–24 years from a remote pastoral community in Northeastern, Uganda
BACKGROUND: Contraceptive prevalence in the Karamoja region of Northeastern Uganda is 10%, compared to the national prevalence of 38%. Young people aged 15–24 years have limited access to contraceptive services in this region. This study assessed the determinants of contraceptive use and intention…
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Artikel Jurnal Teks lengkap
Effects of multicomponent exercise injury prevention programs on adolescent team athletes (10–19 years old): a systematic review and meta-analysis
OBJECTIVE: The aim of this study was to assess the efficacy of multicomponent exercise injury prevention programs in adolescent team athletes and to determine the optimal training programs characteristics, including program duration and potential sex-related differences, through subgroup analysis…
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Artikel Jurnal Teks lengkap
Refined target-mediated drug disposition modeling of the anti-tissue factor pathway inhibitor antibody MG1113 in cynomolgus monkeys and rabbits
INTRODUCTION: MG1113 is a humanized immunoglobulin G4 antibody targeting the Kunitz-type protease inhibitor 2 domain of tissue factor pathway inhibitor (TFPI) and is under clinical investigation for hemophilia treatment. This study aimed to refine a previously developed target-mediated drug…
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Artikel Jurnal Teks lengkap
From detection to remediation: the potential of phosphomelanin in sustainable environmental solutions
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Artikel Jurnal Teks lengkap
Work connectivity behavior after-hours and occupational fatigue in OR nurse-parents: a latent profile analysis and the mediating role of psychological detachment
BACKGROUND: In China, work connectivity behavior after-hours (WCBA) among operating room nurse who are parents (OR nurse-parents) are associated with increased occupational fatigue, whereas psychological detachment may serve as a potential protective factor. A thorough understanding of the…
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Artikel Jurnal Teks lengkap
Dietary antigens drive the generation of functional cytotoxic intraepithelial lymphocytes for early defense against foodborne pathogens
INTRODUCTION: Intraepithelial lymphocytes (IELs) constitute the largest lymphocyte population in the body and exhibit direct cytotoxic effector functions. Despite their abundance and importance in mucosal immunity, the mechanisms governing the generation and maintenance of functional IELs remain…
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Artikel Jurnal Teks lengkap
An observational study of the reliability and concurrent validity of heart rate variability devices in athletes
BACKGROUND: Heart rate variability (HRV) is a non-invasive indicator of autonomic nervous system function and is increasingly used in athlete monitoring. While electrocardiography (ECG) is the gold standard for HRV measurement, its use is limited in field settings. OBJECTIVE: To evaluate the…
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Artikel Jurnal Teks lengkap
XPNPEP2 regulates angiogenesis via modulation of mitochondrial function through SLC25A6
X-prolyl aminopeptidase 2 (XPNPEP2), which is abundantly expressed in vascular endothelial cells (ECs), has been reported to be associated with cardiovascular disease and angiogenesis. However, its function in ECs and its involvement in the pathogenesis of angiogenesis remain unclear. In this…
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Artikel Jurnal Teks lengkap
Improving self-care, HbA1c control, and quality of life in type 2 diabetes: a self-regulation intervention based on the individual and family self-management theory
BACKGROUND: Type 2 diabetes mellitus (T2DM) remains a global health challenge, often associated with poor self-care, inadequate glycemic control, and reduced quality of life. Conventional diabetes education mainly focuses on biomedical aspects, with limited attention to psychological…
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Artikel Jurnal Teks lengkap
Editorial: Cell-mediated innate immunity in aquatic invertebrates and fish: what’s new?
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Artikel Jurnal Teks lengkap
Molecular characterization of cell decay in inflammation and topological assignment of released cfDNA for integrative laboratory and radiological outcome assessment
BACKGROUND: Integrative biomarkers could aid in the efficient triage of vulnerable patients with systemic infectious diseases. Thus, we investigated cfDNA integrity, cfDNA epigenetics, and radiomics for their potential as prognostic biomarkers for clinical courses in ARDS and systemic involvement…
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Leveraging disease outbreak news to strengthen the global response to antimicrobial resistance: a call for action
Antimicrobial resistance (AMR) is an escalating global health threat, with low- and middle-income countries (LMICs) bearing the greatest burden as healthcare facilities become breeding grounds for resistant pathogens, leading to increased morbidity, mortality, and straining of already limited…
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Dezocine and butorphanol for the prevention of sufentanil-induced cough: a randomized controlled trial investigating the impact of intravenous access site
INTRODUCTION: Sufentanil, a potent opioid commonly used for anesthesia induction, is frequently associated with a cough reflex that may compromise airway stability and elevate intracranial or intraocular pressure. While pretreatment with opioids such as dezocine or butorphanol has been proposed to…
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Artikel Jurnal Teks lengkap
Physiological, anatomical, and molecular responses of glanded and glandless cotton to chromium exposure
Cotton seeds are a major source of high-quality proteins and edible oil, but their utilization is limited due to gossypol toxicity to humans and animals. For better use of cotton as food and feed, several glandless cotton cultivars have been developed, which are susceptible to various biotic…
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Artikel Jurnal Teks lengkap
Subcutaneous versus intravenous trastuzumab for HER2-positive breast cancer: a global systematic review and meta-analysis with a cost-minimization analysis from the Chinese healthcare system perspective
BACKGROUND: Subcutaneous (SC) trastuzumab offers a more convenient alternative to intravenous (IV) administration for HER2-positive breast cancer, potentially improving healthcare efficiency and patient experience. Although SC trastuzumab was approved in Europe in 2013 and in the United States in…
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Artikel Jurnal Teks lengkap
Identification of multiple prognostic biomarker sets for risk stratification in SKCM
INTRODUCTION: The majority of available transcriptomics-related cancer prognosis studies strive to define one collection of biomarkers that can be used to predict high-risk patients. However, using a single biomarker profile could restrict its strength and applicability to diverse groups of…
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Artikel Jurnal Teks lengkap
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma
INTRODUCTION: Melanoma is a highly immunogenic and aggressive malignancy characterized by pronounced intratumoral lymphocytic infiltration and significant responsiveness to immunotherapeutic interventions. The oncogenic glycoprotein podoplanin (PDPN) is commonly overexpressed in various cancer…
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