11.943.971 hasil
Menampilkan 881–900 · 2,35 detik · RSS
-
Artikel Jurnal Teks lengkap
Characteristics of adverse events and clinical risks of intravenous immunoglobulin: a pharmacovigilance study based on FDA Adverse Event Reporting System (FAERS)
BACKGROUND: Intravenous immunoglobulin (IVIg) is widely used to treat primary immunodeficiency, chronic inflammatory demyelinating polyneuropathy, immune thrombocytopenia, and other disorders. Although effective in maintaining IgG trough levels and reducing infections, its safety profile requires…
-
Artikel Jurnal Teks lengkap
Advances in pulmonary neuroendocrine cells and their cellular interactions in asthma pathogenesis
Asthma is a complex chronic inflammatory airway disease, whose pathogenesis involves interactions among multiple cell types and molecular pathways. Pulmonary neuroendocrine cells (PNECs), rare epithelial cells in the lungs, have recently gained attention as pulmonary sensors. PNECs detect…
-
Artikel Jurnal Teks lengkap
Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2
Preclinical and clinical evidence suggested the potential benefits of treatment with acetylsalicylic acid (ASA) in mitigating COVID-19 severity. While available studies largely focused on the intracellular pathways through which ASA impairs viral replication or dampens host immunoresponse…
-
Artikel Jurnal Teks lengkap
Development of an interpretable machine learning model for predicting venous thromboembolism in intensive care unit patients with intracerebral hemorrhage
BACKGROUND: Venous thromboembolism (VTE) is a frequent and potentially life-threatening complication in patients with intracerebral hemorrhage (ICH) in intensive care units (ICU). However, the necessity of prophylactic anticoagulation therapy for these patients remains controversial. This study…
-
Artikel Jurnal Teks lengkap
OxyR contributes to the oxidative stress capacity and virulence of hypervirulent Klebsiella pneumoniae ATCC 43816
INTRODUCTION: Hypervirulent Klebsiella pneumoniae (hvKP) is an emerging pathogen associated with severe invasive infections and high mortality, in which resistance to host-derived reactive oxygen species (ROS) is critical for immune evasion and persistence. However, the mechanisms underlying…
-
Artikel Jurnal Teks lengkap
Long-term relapse: markers, mechanisms, and implications for disease management in alcohol use disorder
OBJECTIVE: Much has been theorized and documented about factors involved in alcohol use disorder (AUD) relapse during the early months following a recovery attempt where biobehavioral classical conditioning (“cues/triggers”) and neurophysiological explanatory theories predominate. Little has been…
-
Artikel Jurnal Teks lengkap
Monocyte IL-1β predicts adverse cardiovascular events and associates with coronary microvascular dysfunction in kidney transplant recipients
AIMS: Cardiovascular disease remains the leading cause of death after kidney transplantation. Coronary microvascular dysfunction (CMD) is common in kidney transplant recipients (KTRs), prognostically informative for cardiovascular events, and tightly related to inflammation. We aimed to test…
-
Artikel Jurnal Teks lengkap
Neuroendoscopic surgery for septated chronic subdural hematoma
OBJECTIVE: To explore the clinical efficacy of neuroendoscopic surgery in the treatment of septated chronic subdural hematomas (sCSDH). METHODS: A retrospective analysis was conducted on the clinical data of 97 patients with sCSDH admitted to the Department of Neurosurgery, Wuxi Second People's…
-
Artikel Jurnal Teks lengkap
The improvement effect and mechanism of traditional Chinese medicine on chemotherapy-induced diarrhea: a systematic review
Chemotherapy-induced diarrhea (CID) is one of the gastrointestinal adverse effects in cancer patients after chemotherapy, which seriously affects the course of chemotherapy and reduces the survival rate of patients. The medications commonly used to improve CID include loperamide and octreotide…
-
Artikel Jurnal Teks lengkap
Challenges of monocyte HLA-DR targeted immunomodulation in sepsis—a prospective observational cohort study
INTRODUCTION: Reduced monocyte HLA-DR expression, a hallmark of immunosuppression in sepsis, is associated with infectious complications and mortality. Therapeutic strategies, including IFN-γ, have been used to restore monocyte HLA-DR and immune function, but have not consistently improved clinical…
-
Artikel Jurnal Teks lengkap
Steaming duration-dependent effects on the in vivo distribution, anti-fatigue activity, and gut microbiota modulation of Polygonatum cyrtonema Hua polysaccharides
BACKGROUND: Polygonatum cyrtonema Hua is a traditional medicinal plant widely used for its anti-fatigue properties, with its polysaccharides (PCPs) believed to play a key role in these effects. Steaming, a necessary step before consumption, can alter the structure of PCPs. However, the impact of…
-
Artikel Jurnal Teks lengkap
Opposing fates: a bipolar cellular model for FMDV replication shaped by (12)C(6+)heavy-ion mutagenesis
INTRODUCTION: By pioneering the use of an 80 MeV/u (12)C(6+) heavy-ion beam for mutagenesis, we have engineered a stably polarized BHK-21 cell model for FMDV replication. METHODS: This approach yielded two distinct clones: a highly antiviral line (BHK-5) and a highly proviral line (BHK-7)…
-
Artikel Jurnal Teks lengkap
How prepared are dental students to manage medical emergencies, a cross-sectional survey from Saudi Arabia
BACKGROUND: Medical emergencies (MEs) in dental practice, though rare, can occur posing significant risks to patients. Dental professionals should be well-prepared to manage such situations. This study aimed to assess the knowledge, self-perceived confidence and preparedness of dental students and…
-
Artikel Jurnal Teks lengkap
Venetoclax concentration affects the incidence of haematological adverse events in patients with acute myeloid leukaemia
INTRODUCTION: Venetoclax (VEN) demonstrates considerable inter-individual variability in drug exposure, and its pharmacokinetics are substantially influenced by concurrent administration of CYP3A inhibitors. This study explores the relationship between VEN exposure and the incidence of…
-
Artikel Jurnal Teks lengkap
The use of applied improvisation at university: a mini-review
AIM: This mini review aimed to synthesize current evidence on applied improvisation programs in higher education across disciplines, identifying their impact, implementation, evaluation methods, and future research directions. METHODS: Following PRISMA-ScR guidelines, a systematic search was…
-
Artikel Jurnal Teks lengkap
Whole-genome identification of LdELF4s and analysis of their expression response to diurnal temperature variations in Lilium davidii var. willmottiae (E. H. Wilson) raffill
INTRODUCTION: Lanzhou lily (Lilium davidii var. willmottiae), a medicinal and edible plant endemic to China, synthesizes bioactive compounds regulated by diurnal temperature variations (DIFs). ELF4 family genes, key regulators coordinating endogenous rhythms with external changes, are unexplored in…
-
Artikel Jurnal Teks lengkap
Systematic evaluation of pigment-based whole-cell lead biosensors: challenges in genetic circuit engineering and critical considerations for background noise control
INTRODUCTION: Despite advances in whole-cell biosensors for Pb(II) detection, background leakage and limited dynamic range hinder field deployment. This study systematically evaluates four diverse pbr operons and optimizes genetic circuit architectures to develop high-performance pigment-based…
-
Artikel Jurnal Teks lengkap
Paper vs. screen: inclination matters during global–local visual processing
The use of new technologies has opened the field to numerous studies regarding their impact on cognition. While many studies have suggested that paper presents an advantage over screens, the impact of the medium during local–global visual attentional processes has never been investigated. Visual…
-
Artikel Jurnal Teks lengkap
Factors influencing cardiovascular disease screening uptake and implementation strategies to enhance cardiovascular disease screening uptake in Singapore adults: a multi-method study protocol
INTRODUCTION: The prevalence of cardiovascular diseases (CVD) and CVD risk factors such as Type 2 Diabetes Mellitus (T2DM), hypertension and hypercholesterolemia has increased steadily worldwide. Population health screening is a common effort that promotes early detection, better prognosis and…
-
Artikel Jurnal Teks lengkap
The impact of health literacy on treatment adherence in COPD patients: chain mediation roles of self-efficacy and perceived disease threat
BACKGROUND: Treatment adherence in patients with chronic obstructive pulmonary disease (COPD) is a critical factor influencing disease prognosis and quality of life. Health literacy, defined as patients’ ability to acquire and apply health information, may indirectly modulate adherence behaviors…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.