11.943.971 hasil
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Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF–induced trained immunity
Granulocyte-macrophage colony-stimulating factor (GM-CSF) contributes to the host defense and the pathogenesis of inflammatory diseases at least in part through inducing trained immunity (TI), however, the mechanism remains poorly characterized. In this paper, we systematically investigated the…
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Analysis of selected cytokines, NLRP3 inflammasome and α-Klotho protein in patients with heart failure after ICD/CRT-D high-voltage intervention
OBJECTIVES: Inflammatory cytokines contribute to Implantable Cardioverter-Defibrillator/Cardiac Resynchronization Therapy with a Defibrillator (ICD/CRT-D) high-voltage intervention by promoting arrhythmias through direct cardiac effects and indirect systemic changes. The NLRP3 inflammasome can…
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Case Report: Guillain−Barré syndrome temporally associated with levofloxacin exposure and improvement following efgartigimod treatment
Levofloxacin, the L-isomer of the racemic fluoroquinolone ofloxacin, is a broad-spectrum antibiotic with broad clinical applications in both prophylactic and therapeutic indications. However, it has been associated with various adverse reactions, including Guillain−Barré syndrome (GBS). GBS is an…
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Latent profiles of volume management behaviors and their relationship with symptom distress in patients with chronic heart failure
OBJECTIVE: To explore the latent categories of volume management behaviors in patients with chronic heart failure (CHF) and analyze their relationship with symptom distress. METHODS: This cross-sectional study utilized a convenience sampling method to select 552 CHF patients from the cardiology…
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Developing evaluation index system for “new medicine” construction in Chinese medical schools—meta-ethnography and Delphi-AHP approach
OBJECTIVE: This study intends to construct a scientific, comprehensive and operable evaluation index system for the constructing achievements of “New Medicine” in medical schools and contribute to promoting the innovative development of medical education in China. METHODS: The study adopted a…
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m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis
BACKGROUND: Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) are life-threatening complications that often arise after CAR T-cell immunotherapy. Endothelial dysfunction is believed to play a central role in their development, leading to the interest…
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The invasive GAS puzzle in Italy: genomic insights from a hospital cohort in a fragmented surveillance landscape
Streptococcus pyogenes (Group A Streptococcus, GAS) is a re-emerging human pathogen responsible for a wide spectrum of diseases, from mild pharyngitis to life-threatening invasive infections that have risen globally in recent years. We performed a retrospective genomic and epidemiological analysis…
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Exosomes in early lung cancer diagnostics: the current state of progress made and prospects
The high mortality rate of lung cancer primarily results from its late-stage diagnosis, at which point metastasis has usually occurred and therapeutic options are limited, leading to an overall 5-year survival rate below 20% in most countries. The current screening method, low-dose computed…
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Gender disparities in out-of-hospital cardiac arrest: implications for public health and bystander interventions in Zhengzhou
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) remains a critical public health crisis in China, with survival rates below 1%, notably lower than those reported in developed nations (10%–12%). Gender disparities have emerged as crucial determinants of OHCA outcomes; however, China-specific…
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Development of a questionnaire for assessing the use of ChatGPT in primary and secondary disease prevention
BACKGROUND: Many individuals seek health-related guidance through ChatGPT OpenAI (San Francisco, CA, USA), due to its convenience and perceived reliability, often in place of, or as a supplement to, professional medical advice. This raises concerns about the accuracy of information provided and the…
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Proteomic analysis of heparin amelioration of cardiac injury after CA-CPR in rats: an exploratory proteomic study
BACKGROUND: Patients who recover from cardiac arrest with autonomous circulation often have a poor prognosis due to myocardial dysfunction. Heparin, a pleiotropic drug, has not yet been identified for its myocardial protection mechanism in addition to anticoagulation. The aim of this study was to…
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Epidemiological characteristics and genomic analysis of respiratory adenovirus in Lanzhou City from 2023 to 2025
OBJECTIVE: Human adenoviruses (HAdVs) are common pathogens causing inflammation in the upper respiratory tract, lungs, conjunctiva, urinary tract, and gastrointestinal tract. They can lead to severe, even fatal infections in immunocompromised patients, representing a significant public health…
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Risk factors for sacrococcygeal pilonidal sinus: a systematic review and meta-analysis supplemented by genetic causal assessment
OBJECTIVE: Sacrococcygeal pilonidal sinus (PS) is a common, chronic, and recurrent condition with unclear pathogenesis. Previous studies have primarily focused on local factors, with limited causal validation of systemic risk factors. This study aims to synthesize observational and genetic evidence…
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Humans optimally integrate cutaneous and proprioceptive cues in haptic size perception
Sensory perception relies on the brain's integration of multiple imprecise inputs, a process known as cue combination. Previous research has investigated multisensory integration or unisensory integration within non-haptic senses. In contrast, cue combination within the sense of touch has been…
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Rapid point-of-care quantification of high-sensitivity C-reactive protein in pulpal blood as an objective biomarker for irreversible pulpitis: a pilot diagnostic accuracy study
The diagnosis of irreversible pulpitis relies on subjective clinical criteria and low-specific sensitivity tests, potentially leading to inappropriate treatment decisions. High-sensitivity C-reactive protein (hs-CRP) is locally expressed in inflamed pulp tissues and may provide objective diagnostic…
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Deciphering the immunomodulatory mechanisms of Periplaneta americana L. extract CII-3: insight from integrated metabolomics and network pharmacology
BACKGROUND: Periplaneta americana L. is one of the most famous traditional Chinese medicines (TCMs), and CII-3 is the major bioactive extract of Periplaneta americana L. In recent years, CII-3 has gradually attracted the attention of researchers for its powerful capacity for treating…
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GelMA–GelDopa–Sr double-network hydrogel promotes skin regeneration by enhancing angiogenesis and macrophage polarization
INTRODUCTION: Chronic skin defects typically exhibit persistent inflammation, damaged cell regeneration, and insufficient vascularization, all of which severely impede the healing process. Traditional skin dressings merely serve to cover the wound and do not actively promote wound healing. They…
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Effect of preoperative oral isomaltulose on insulin resistance and glycemic variability in patients with type 2 diabetes mellitus: a randomized controlled trial
BACKGROUND/OBJECTIVES: Preoperative oral carbohydrate alleviates postoperative insulin resistance and enhances recovery. Its utility in type 2 diabetes mellitus (T2DM) is debated due to hyperglycemia risks. Isomaltulose, a low-glycemic-index carbohydrate, has been shown to effectively attenuate…
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Evolving culturally competent veterinary care: a community-based partnership with the Santee Nation
Access to veterinary care remains a profound equity issue across the United States, particularly in Indigenous communities where animals hold vital cultural and spiritual significance. This case study examines a longitudinal, community-based partnership between Kansas State University’s College of…
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Topography and functional traits shape the distribution of key shrub plant functional types in low-Arctic tundra
The expansion of shrubs in the Arctic tundra fundamentally modifies land-atmosphere interactions. However, it remains unclear how shrub distribution and expansion differ across key species due to challenges with discriminating tundra plant species at regional scales. Here, we combined multi-scale…
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