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Mechano-electrical-fluid interaction left-ventricle model for numerical evaluation of aortic valve hemodynamics
BACKGROUND AND OBJECTIVE: Aortic valve simulation has a crucial meaning for clinical applications like the prediction of transcatheter aortic valve implantation or the Ozaki procedure. One of the main aspects is the inflow boundary condition because it has a strong effect on hemodynamic flow…
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School guidance support and growth in mathematics discourse feedback skills: a three-wave longitudinal mediation study
INTRODUCTION: Feedback improves learning when students can interpret evaluative information, justify reasoning, monitor progress against explicit criteria, diagnose errors, and implement targeted revisions in classroom dialogue. This study tested whether school guidance support fosters growth in…
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An integrative review of the physical, mental, and socioeconomic benefits of outdoor hiking
In recent years, outdoor hiking has garnered global attention as an effective health promotion activity. This review synthesizes relevant literature from various databases up to October 2025, assessing the physiological, psychological, and socio-economic impacts of outdoor hiking on individuals…
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κ-opioid receptor: from analgesic target to neuroimmune hub
Originally characterized as a classical mediator of analgesia, the κ-opioid receptor (KOR) has recently emerged as a pivotal regulator at the crossroads of the nervous and immune systems. Beyond its canonical role in nociceptive processing, a growing body of evidence reveals that KOR exerts…
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NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer
BACKGROUND: Resistance to epidermal growth factor receptor monoclonal antibodies (anti-EGFR), such as cetuximab, remains a major therapeutic challenge. Growing evidence suggests that local tumor immune cells and systemic inflammation influence therapeutic outcomes. Our study aimed to investigate…
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Cold exposure and the cardiovascular system: from physiological adaptation to pathological risk
Cold stress is the therapeutic paradox of cardiovascular medicine: both an established environmental trigger of acute death and a physiological stimulus for powerful adaptation. In this review, we address this paradox critically. The response to cold challenge, which ranges from sympathetic…
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Genomic analyses of 238 seed plants reveal the evolutionary mechanisms driving specialization of F3H, ANS, and FLS in flavonoid biosynthesis
INTRODUCTION: Flavonoid metabolism innovation is critical for seed plants’ terrestrial adaptation. Three key 2-oxoglutarate-dependent dioxygenase (2ODD) families—F3H, ANS, FLS—underpin flavonoid biosynthesis, but their evolutionary diversification mechanisms remain unclear. METHODS: Comprehensive…
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Determination of canine ROTEM Sigma reference ranges and comparative analysis with ROTEM Delta
INTRODUCTION: Hemostatic dysfunctions are frequent in critically ill dogs and can markedly affect clinical outcomes. Conventional plasma-based coagulation testing provides limited insight into the complex in vivo interactions among platelets, red blood cells, and coagulation factors. Viscoelastic…
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Meta-analysis of the effects of mental health literacy intervention on teachers: knowledge, stigma, help-seeking, and helping
Given its critical role in promoting students’ mental health and wellbeing, research on mental health literacy has increasingly focused on both in-service and pre-service teachers. We conducted this meta-analysis to examine the effectiveness of mental health literacy interventions aimed at teachers…
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Case Report: Metastasis of low-grade endometrial stromal sarcoma to the inferior vena cava and right atrium: a case of successful one-stage surgical resection with favorable early outcome
Low-grade endometrial stromal sarcoma (LGESS) is a rare uterine malignancy; metastasis to the inferior vena cava (IVC) and right atrium is exceptionally rare and presents significant diagnostic and therapeutic challenges. We report the case of a 37-year-old woman presenting with progressive…
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How do we identify potential perpetrators of indirect bullying and how do we help them? A review of the characteristics that are associated with perpetration and can be targeted through prevention and intervention
Identifying those who are likely to become perpetrators of bullying may help direct prevention strategies to those who are most at risk of engaging in peer victimization. Meta-analyses have suggested that antibullying interventions are modestly effective only for students in grades 7 or below. Such…
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Primary antiphospholipid syndrome complicated by recurrent acute ST-elevation myocardial infarction: a case report
Clinical management of primary antiphospholipid syndrome (PAPS) complicated by acute myocardial infarction (AMI) is particularly challenging, especially when recurrent AMI and thrombocytopenia are present. This case report describes a 35-year-old male patient with PAPS who experienced two episodes…
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Efficacy and safety of probiotics combined with bismuth-containing quadruple therapy for Helicobacter pylori eradication: a systematic review and meta-analysis
OBJECTIVE: Helicobacter pylori (H. pylori) infection represents a global health challenge. This study aimed to evaluate the effect of probiotic supplementation on the efficacy and safety of bismuth-containing quadruple therapy (BQT) for H. pylori eradication. METHODS: Randomized controlled trials…
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A narrative review of the application of the survey experiment in sports psychology: research design and method
INTRODUCTION: As a research paradigm integrating internal and external validity, the survey experiment method has been widely used in the humanities and social sciences. However, there is currently no research that provides a comprehensive summary of the application of survey experiment in sports…
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Case Report: Perioperative application of trastuzumab deruxtecan in HER2 exon 20 mutation-positive non-small cell lung cancer
BACKGROUND: Lung adenocarcinoma with HER2 exon 20 insertions represents a rare subset of non-small cell lung cancer (NSCLC) associated with aggressive behavior and limited treatment options. CASE DESCRIPTION: This case report highlights the first perioperative use of trastuzumab deruxtecan (T-DXd)…
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Molecular subtyping and functional characterization of gastric cancer using arginine metabolism-related genes
BACKGROUND: Gastric cancer (GC) remains one of the most lethal malignancies worldwide due to its substantial heterogeneity, necessitating improved therapeutic strategies and prognostic tools. Recent studies have implicated dysregulated arginine metabolism in GC pathogenesis; however, its metabolic…
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The role of enamel matrix derivatives in periodontal regeneration following tooth replantation/transplantation: a narrative review of post-reperfusion injury
OBJECTIVE: The autogenous tooth transplantation and tooth replantation disrupt the original dental pulp and periodontal blood supply. Pulp necrosis post-reimplantation triggered inflammatory mediator leakage through the apical foramen, which stimulated periapical osteoclast activity and subsequent…
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Assessment of the phi6 lysis system using genetic complementation and heterologous expression in Escherichia coli and Pseudomonas syringae
The RNA cystovirus phi6 represents a unique evolutionary outlier, encoding a holin and endolysin similar to tailed phages, yet lacking an identified gene for outer membrane disruption. In this study, we investigated the phi6 lysis system using genetic complementation experiments and heterologous…
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Metagenomic exploration of the virome of Rhipicephalus sanguineus ticks from Chachoengsao, Thailand
Ticks are obligate blood-feeding ectoparasites that harbor a wide diversity of microorganisms. Rhipicephalus sanguineus, the brown dog tick, is globally distributed and poses significant veterinary and public health concerns due to its close association with companion animals and its occasional…
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