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Determinants of abnormal liver-related biomarkers in adult COVID-19 patients
BACKGROUND: Serum hepatic injury markers indexes are altered in COVID-19 patients. We aimed to explore the factors that could be associated with abnormal serum hepatic injury markers in adult COVID-19 patients. METHODS: Eight main hepatic injury markers were examined. Demographic and hematological…
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Biomechanics-based analysis of technical characteristics in skeleton start and specific physical training strategies
PURPOSE: This study employed kinematic and kinetic testing to analyze the sport-specific parameters of the skeleton start, thereby elucidating its technical characteristics and establishing an empirical basis for training. METHODS: Spatiotemporal parameters were captured using a 3D motion system…
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A prognostic signature derived from ac4C-associated genes stratifies survival and tumor immune microenvironment in cutaneous melanoma
The clinical management of cutaneous melanoma (SKCM) is particularly challenging due to the disease’s high degree of heterogeneity, which leads to unpredictable patient outcomes and highly variable responses to therapy. Clinicians are in urgent need of a reliable molecular profile system to predict…
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Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting
Asthma, a heterogeneous chronic respiratory disorder affecting millions globally, is driven by complex interactions between genetic susceptibility, environmental triggers, and dysregulated immunity. Emerging evidence positions ferroptosis, an iron-dependent form of regulated cell death…
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The application value and limitations of metagenomic detection technology based on cerebrospinal fluid samples in suspected central nervous system infection: a retrospective study
BACKGROUND: Accurately diagnosing central nervous system (CNS) infections remains challenging. This study aimed to evaluate the effectiveness of metagenomic next-generation sequencing (mNGS) in diagnosing suspected CNS infections and its role in facilitating rapid and accurate pathogen…
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Cellular insights into transposable elements in Alzheimer’s disease
INTRODUCTION: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. While advances in single-cell technologies have elucidated cellular diversity and transcriptional changes in AD, the contribution of transposable elements (TEs) to disease pathogenesis…
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Pretreatment cancer related cognitive impairment and associated psychological factors: a systematic review
INTRODUCTION: Cancer related cognitive impairment (CRCI) describes issues patients can experience with attention, memory and focus. Understanding the causes of CRCI and the experience of CRCI prior to surgery or treatment is important. Exploring the role of anxiety and depression can aid in…
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Diagnostic and therapeutic challenges of diffuse abdominal infantile hemangioma: a case report emphasizing multimodality imaging and multidisciplinary management
BACKGROUND: Diffuse abdominal infantile hemangioma (DAIH) is an exceptionally rare and life-threatening vascular anomaly, characterized by extensive infiltrative growth. It poses significant diagnostic challenges by mimicking malignancy and therapeutic difficulties due to involvement of critical…
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CGR11 promotes hepatocellular carcinoma progression by regulating autophagy through the PI3K/AKT pathway
BACKGROUND: Hepatocellular carcinoma (HCC), the predominant pathological subtype of primary liver cancer, remains a major global health burden with poorly defined molecular mechanisms. Cell growth regulator 11 (CGR11), a novel secreted protein characterized by EF-hand motifs, has recently emerged…
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A novel variant in SIAH1 associated with autosomal dominant Buratti-Harel syndrome
INTRODUCTION: Buratti-Harel syndrome (BURHAS) is a rare autosomal dominant neurodevelopmental disorder caused by SIAH1 (Siah1 E3 ubiquitin ligase) variants, characterized by infantile hypotonia, global developmental delay, and variable multisystem involvement. To date, 13 pathogenic SIAH1 variants…
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Structured reporting enhances diagnostic quality in periapical dental radiographs: a comparative evaluation
BACKGROUND: Radiological reports are critical for accurate diagnosis and therapeutic decision-making. While narrative free-text reports remain the conventional standard in dental radiology, structured reporting has emerged as a promising approach to enhance report quality, consistency, and clinical…
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The predictive effects of individual difference factors on L2 writing complexity, accuracy, and fluency
Drawing on the control-value theory and the individual-environmental model of writing, this study investigated the predictive effects of various individual difference factors (i.e., L2 writing grit, enjoyment, anxiety, motivation, and working memory) on L2 writing syntactic complexity, accuracy…
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A high content (30%) stable doxycycline hyclate drinking-water solution for broilers: preparation, stability, and bioequivalence
INTRODUCTION: Doxycycline is a semi-synthetic tetracycline antibiotic with broad-spectrum antimicrobial activity. Under intensive animal husbandry, commercially available doxycycline drinking-water formulations often show several drawbacks in solubility, stability and homogeneous distribution under…
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Elucidating the role of SHROOM4 in non-small cell lung cancer: expression patterns, clinical correlations, and potential functions
BACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the most common type. SHROOM4, a protein integral to cytoskeletal organization and cellular signaling, has not been extensively studied in NSCLC. METHODS: Through…
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Economic costs of veterinary drug and antibiotic use in commercial dairy cattle herds in Central European countries
Antimicrobial use in livestock production is a critical issue in terms of both animal health and public health, particularly due to its role in the emergence of antimicrobial resistance (AMR). In this study, the veterinary drug costs, with a particular focus on antibiotics, were surveyed in 20…
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High-throughput identification of immunoreactive peptides and corresponding proteins from Anaplasma platys and Ehrlichia canis using peptide microarray chips
INTRODUCTION: Anaplasma platys and Ehrlichia canis are rickettsial pathogens infecting dogs, with a worldwide distribution. Both species are obligate intracellular pathogens and colonize bone marrow-derived cells, with coinfections frequently reported in dogs. Although E. canis immunodominant…
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Clinical outcomes of aortic stenosis patients undergoing Impella-supported high-risk percutaneous coronary intervention
BACKGROUND: Severe aortic stenosis (AS) is associated with an increased risk of adverse outcomes in patients undergoing percutaneous coronary intervention (PCI). While Impella-supported high-risk PCI (HRPCI) has demonstrated improved outcomes, its safety in patients with AS remains inadequately…
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Telitacicept for systemic lupus erythematosus-associated peripheral neuropathy: a case report
Peripheral neuropathy (PN) is a challenging manifestation of systemic lupus erythematosus (SLE) with limited evidence-based treatment guidelines. Current standard therapies, including glucocorticoids (GCs) and cyclophosphamide (CYC), are often effective but carry significant risks, such as gonadal…
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