11.943.971 hasil
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Ex vivo mucosal cultures: an emerging player in vaccine development
Increased awareness of pathogens with pandemic potential, especially respiratory viruses, is driving research on next-generation mucosal vaccines. However, clinical translation is still hampered by the lack of relevant experimental systems. Here, we review advances in human mucosal ex vivo cultures…
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A rare case of human infection with Orf virus in China, 2024
Orf virus is a globally distributed zoonotic pathogen that mainly infects sheep and goats, although cases of human infection have been occasionally reported. In this study, we reported a rare case of human infection with Orf virus in China. A 66-year-old shepherd in Jining City of Shandong…
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Case Report: Subcapsular hematoma post-transarterial embolization and its laparoscopic resolution
BACKGROUND: Hepatic hemangioma (HH) is a common benign liver tumor. Transarterial embolization (TAE) is a widely adopted minimally invasive treatment. Subcapsular hematoma (SCH) is an exceptionally rare and severe complication following TAE, with only sporadic cases reported and no standardized…
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Preliminary evaluation of full volume strain measurement in patellar cartilage following osteochondral allograft transplantation using magnetic resonance imaging
INTRODUCTION: Articular cartilage (AC) defects of the patellofemoral joint (PFJ) are clinically challenging and mechanically demanding. Osteochondral allograft (OCA) transplantation is the standard treatment for large cartilage injuries; however, little is known about intra-tissue mechanics after…
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Effectiveness and implementation of simulation training in obstetric and gynecological surgery education: systematic review and meta-analysis
This systematic review and meta-analysis evaluated the effectiveness and implementation of simulation-based training in obstetrics and gynecology surgical education. Following PRISMA 2020 guidelines, multiple databases were searched through December 2024, ultimately including 30 randomized…
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From distraction to addiction? Understanding academic cyberslacking as a behavioral dependency among medical students
BACKGROUND: Academic cyberslacking among medical students represents a complex behavioral adaptation shaped by personal, technological, and institutional factors. This study explores its triggers, sustaining mechanisms, and long-term impacts, addressing how digital distractions evolve into…
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Assessment of the effectiveness of exercise interventions in the treatment of PTSD: based on a systematic evaluation and meta-analysis
BACKGROUND: Physical exercise is increasingly recognized for its potential to alleviate symptoms of post-traumatic stress disorder (PTSD). However, uncertainty remains regarding which exercise modalities are most effective, optimal prescription parameters, and which patient populations benefit…
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When viral infections meet the anti-MDA5 antibody-positive dermatomyositis
Anti-melanoma differentiation-related gene 5 (MDA5) antibody-positive dermatomyositis (anti-MDA5(+) DM) is recognized as a distinct subtype of dermatomyositis, characterized by its frequent association with interstitial lung disease (ILD), particularly rapidly progressive ILD (RP-ILD), which is…
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The association between history of appendectomy and gut microbiota composition: a follow-up cross-sectional study
INTRODUCTION: The appendix is thought to act as a regulatory immune organ and gut microbiota reservoir. Although appendectomy is linked to health risks, its impact on the gut microbiota remains understudied. METHODS: This study is conceived as a cross-sectional retrospective follow-up study. Three…
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Effect of rear impact on the instrumented cervical spine: a finite element study
INTRODUCTION: Degenerative cervical myelopathy (DCM) is a leading cause of spinal cord dysfunction and often requires surgical decompression and instrumentation. Anterior cervical discectomy and fusion (ACDF) is the most commonly performed procedure, but the biomechanical response of instrumented…
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Contrasting immune responses in COVID-19: insights from healthcare workers and infected patients on plasmablast, pDC, and NK cell dynamics
BACKGROUND: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted significant variability in disease severity, ranging from asymptomatic cases to severe acute respiratory distress syndrome. OBJECTIVE: Understanding the immune responses that contribute to this variability, particularly among…
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Regulatory implementation of Optical Coherence Tomography as an analytical technique in pharmaceutical fillings
Optical Coherence Tomography (OCT) has emerged as a powerful non-destructive imaging tool capable of delivering high-resolution cross-sectional images of drug formulations, particularly useful for evaluating coating uniformity, detecting defects and characterizing multi-layered structures in solid…
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Global research trends on exosomes in atherosclerosis: a bibliometric and scientometric analysis (2004–2025)
BACKGROUND: Exosomes play multifaceted roles in atherosclerosis, contributing to vascular inflammation, immune regulation, and tissue repair. This duality has drawn attention to their potential clinical utility, both as diagnostic indicators and as novel therapeutic avenues. However, despite the…
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A prognostic signature for lung adenocarcinoma in patients who have never smoked
Understanding tumor cell dynamics can improve prognosis and treatment but remains limited for lung adenocarcinoma in people who have never smoked (NS-LUAD). With RNA-seq data from 684 NS-LUAD and validation in an independent dataset, we identified three subtypes with distinct phenotypic traits and…
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Spontaneous massive hemothorax due to inferior phrenic artery pseudoaneurysm: endovascular treatment approach
Inferior phrenic artery (IPA) pseudoaneurysms are highly uncommon and result from trauma, pancreatitis, or iatrogenic injury. However, rupture can lead to catastrophic hemothorax. The vessel’s deep location and non-specific symptoms make early identification a difficult task. We report a case of a…
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Strategy and cost analysis of vascular access for hemodialysis in North Macedonia
BACKGROUND: Vascular access (VA) is a critical component of hemodialysis (HD). Arteriovenous fistulas (AVFs) are associated with lower morbidity and mortality compared to central venous catheters (CVCs). However, VA practice varies across different healthcare systems. OBJECTIVES: The aim of our…
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Fibromuscular dysplasia of the brachial artery diagnosis by Doppler ultrasound: a case report
Fibromuscular dysplasia (FMD) is a disease of non-inflammatory vascular origin that occurs in medium-sized arteries. Its cause is still unknown. The disease mostly affects middle-aged Caucasian women and, in most cases, involves the renal artery. Disease involvement in the arteries of the upper and…
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Incidence and risk factors for contrast-induced nephropathy after angioplasty: an observational retrospective study
BACKGROUND: Contrast-induced nephropathy (CIN) is a complication of iodinated contrast media use that can lead to worsening of renal function, increased morbidity and mortality, and the need for renal replacement therapy. OBJECTIVES: To evaluate the incidence of CIN after angioplasty and identify…
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Hybrid treatment of penetrating trauma of the thoraco-abdominal aorta with bullet embolism to the popliteal artery - case report
Bullet embolism is a rare complication of gunshot wounds, but its incidence has increased due to the increasing number of wounds caused by low-velocity firearms in civilian settings. The increase in urban violence and widespread use of firearms with low-velocity projectiles have made diagnosis of…
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Onion-like carbon unlocks high PdNiO nanocatalyst dispersion for outstanding thermal methane oxidation
Methane must undergo complete catalytic oxidation to reduce the emission of unburned methane from power plants and natural gas engines. However, the poor temperature stability of carbon-based supports frequently restricts their usage in methane oxidation. This limitation can be addressed by…
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