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Restructuring‐Regulated Bismuth Catalyst Promotes Electrochemical CO(2) Reduction to Formic Acid in Acidic Electrolyte
Electrochemical CO(2) reduction (eCO(2)R) in acidic electrolytes is appealing due to its high CO(2) utilization efficiency. For this reaction, bismuth (Bi)‐based catalysts have drawn considerable attention for their potential in producing formate/formic acid. However, the presynthesized materials…
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Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size
BACKGROUND: The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin‐like growth factor (IGF) bioavailability through cleavage of insulin‐like growth factor‐binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep…
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Biomechanical analysis of stair walking patterns and their implications for knee health in young males
OBJECTIVE: Stair ambulation is an essential daily activity associated with maintaining mobility and musculoskeletal health, and its biomechanical characteristics may influence fall risk. This study aimed to examine how different stair-walking strategies—single-step and double-step ascent—affect…
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Negative Reinforcement of Cannabis Use: Subjective Relief from Negative Affect following Cannabis Use and Effects on Subsequent Patterns of Use
BACKGROUND: A few studies have tested for negative reinforcement of alcohol and cannabis use at the daily level by examining changes in negative affect following substance use. However, changes in affect may not be perceived by participants or may not be attributed by participants to substance use…
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Methods of Engaging Interest‐Holders in Healthcare Evidence Syntheses: A Scoping Review
INTRODUCTION: Engaging interest‐holders in health care evidence syntheses may make evidence syntheses more relevant, useful, and accessible. However, the best way(s) to engage interest‐holders within the evidence synthesis process remain unknown. A previous scoping review collated 291 publications…
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CURE ID: a platform to collect real-world treatment data for drug repurposing in rare genetic disorders
Rare diseases collectively affect millions of Americans but less than 5% have approved treatments and new drug development remains limited. For such diseases, drug repurposing may be an effective strategy to find new treatment options. In the rare genetic disorder community, drugs are frequently…
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Age-Related Risk After Kidney Transplantation: A Comprehensive Analysis of Infection Burden, Graft Outcomes, and Mortality
Given the increasing number of kidney transplantation in elderly recipients, understanding age-specific risks is essential for optimized post-transplant care. We analyzed 572 kidney transplant recipients from the DZIF Transplant Cohort (2012–2023), stratified by age: 60 years (n = 147). Outcomes…
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Controlled Human Infection of Healthy Adults With Lyophilized Neisseria lactamica Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali
BACKGROUND: Carriage of Neisseria lactamica (Nlac), a harmless nasopharyngeal commensal, correlates inversely with carriage of Neisseria meningitidis (Nmen), a common cause of meningitis and sepsis outbreaks in sub-Saharan Africa. Nasally administered lyophilized Nlac (LyoNlac) might interrupt…
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Clinical and genetic determinants of survival in amyotrophic lateral sclerosis patients from North India
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration, with significant clinical and genetic variability. While the role of genetic factors is well-established in ALS pathogenesis, their impact on survival outcomes remains…
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Analyses of the Effects of Wild‐Type TDP‐43 Overexpression in Oxytocin Neurons in Mice
Selective TDP‐43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin‐immunopositive cells compared to uninjected mice. AAV‐mediated TDP‐43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and…
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Biomimetic total synthesis of ten Securinega alkaloids
The Securinega alkaloids are a diverse family of polycyclic alkaloids with broad biological importance. In this study, a formal [4 + 2] cycloaddition strategy has been used to complete the biomimetic total synthesis of six Securinega alkaloids, notably using biosynthetically plausible…
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High-sensitivity ethanol vapor detection using In(2)O(3)@ZnO core–shell nanomeshes fabricated via block copolymer templating
Metal-oxide semiconductor nanowires are promising building blocks for high-performance gas sensors due to their high specific surface area and tunable electronic properties. In this work, we adapted a single-step synthesis based on block copolymer templates to fabricate indium oxide (In(2)O(3))…
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Recent progress of METTL3 inhibitors for cancer therapeutics: design, optimization and potential applications
Acute myeloid leukaemia (AML) is a clonal proliferative malignant hematologic disease of hematopoietic stem cells, characterized by the accumulation of immature progenitor cells and the inhibition of hematopoietic function due to blocked differentiation, which is a genetically heterogeneous and…
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Impact of Artificial Intelligence for Detection of Precancerous Colonic Lesions in a Fecal Immunochemical Blood Test‐Based Organized Screening Program in Italy: A Randomized Control Trial
BACKGROUND: The fecal immunochemical test (FIT) is widely implemented as a first‐line tool in organized colorectal cancer (CRC) screening programs, including Italy. Following a positive FIT, colonoscopy is recommended. Computer‐aided detection (CADe) systems have the potential to enhance adenoma…
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Agreement Among Breast Cancer Screening Modalities in Breast Density Assessment and Cancer Risk Prediction
BACKGROUND: Breast density is increasingly recognized as a vital risk factor that affects early breast cancer detection. Therefore, this study was aimed at evaluating the agreement between different breast density measurements across multiple imaging modalities and identifying the best breast…
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Greenness, Whiteness, and Blueness Assessment With a Novel and Fully Validated HPLC Method for Simultaneous Analysis of Lumacaftor and Ivacaftor in Sweat
Sweat is an alternative biological fluid to plasma, urine, hair, and saliva, and it is promising for various pharmaceutical research types. Excessive sweating is one of the symptoms of cystic fibrosis, a hereditary disease. In this study, an easy, simple, applicable, and economical HPLC method was…
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