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Artikel Jurnal Teks lengkap
Anti-tumor activity of trastuzumab deruxtecan in pediatric solid tumors with variable HER2 expression
Trastuzumab deruxtecan (T-DXd) is a HER2-targeting antibody-drug conjugate (ADC) with efficacy across adult cancers exhibiting variable HER2 expression. Prior studies demonstrating HER2 expression in osteosarcoma (OS) motivated a clinical trial of T-DXd in pediatric and adolescent/young adults with…
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Effect of Pitavastatin on Epigenetic Aging Biomarkers in People With HIV: Pilot Substudy of the REPRIEVE Trial
BACKGROUND. People with human immunodeficiency virus (HIV, PWH) exhibit increased cardiovascular disease (CVD) risk and accelerated biological aging. REPRIEVE demonstrated that pitavastatin reduced major adverse cardiovascular events (MACE) in antiretroviral therapy (ART)-treated PWH with…
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Clinical predictors and incidence of Kaposi sarcoma among males with HIV in the Treat-all era in the United States and Canada
BACKGROUND: Stagnating decreases in Kaposi sarcoma (KS) among men with HIV (MWH) following Treat-All policies necessitate evaluating changes in clinical drivers of KS. We examined clinical factors and their associations with KS rates among MWH in North America. METHODS: Among MWH in the North…
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Artikel Jurnal Teks lengkap
EML4-ALK variant-specific genetic interactions shape lung tumorigenesis
Oncogenic fusions of EML4 and ALK occur in ~5% of lung adenocarcinomas. EML4-ALK variants have distinct breakpoints within EML4, but the functional differences among these variants remain poorly understood. Here we use CRISPR/Cas9 somatic genome editing to generate autochthonous mouse models of the…
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Artikel Jurnal Teks lengkap
Experience-dependent Changes in the Visual Processing of Letters: Evidence from Electroencephalography Decoding
Learning to read involves the formation and tuning of letter representations, but it is unknown whether this orthographic tuning influences very early visual processing or only later processing. This study tested the hypothesis that experience increases the extraction of sensory information about…
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Non-canonical HIPPO-MST1/2 promotes hyper-proliferation of pulmonary vascular cells through CDC20
HIPPO components mammalian Ste20-like protein kinases 1 and 2 (MST1/2) are well described growth suppressors. However, in pulmonary arterial hypertension (PAH), MST1/2 switch their roles and become pro-proliferative and pro-survival molecules, supporting hyper-proliferation of pulmonary artery (PA)…
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Mechanistic modeling predicts efficacy of CISH knockout in tumor-infiltrating lymphocytes with synergistic gene editing
Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cell therapy, where the lymphocytes of a cancer patients tumor are harvested, expanded in vitro using IL-2 stimulation, and then infused back into the patient[1], [2]. However, even with the use of TIL therapy, cancer cells can…
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Artikel Jurnal Teks lengkap
Pre- and Postoperative Prescription of Opioids and Benzodiazepines in the US
BACKGROUND: Postoperative opioid and benzodiazepine use often extends beyond recovery, yet research on surgical prescribing tends to focus on opioid-naïve patients. Less is known about those already using these medications preoperatively, who face different risks and care needs. STUDY DESIGN: Using…
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Prospective Comparison of Ultra-high-resolution Photon-counting-detector CT Coronary Angiography versus Conventional CT
OBJECTIVES: Determine differences in quantitative stenosis severity measurements for ultra-high-resolution (UHR) photon-counting-detector (PCD) coronary CT angiography (cCTA) relative to energy-integrating-detector (EID) cCTA in a large patient cohort. METHODS: Adult participants seen between…
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Artikel Jurnal Teks lengkap
Genetic Risk and Transition through Preclinical Stages of Type 1 Diabetes
OBJECTIVE: Our aim was to study the influence of type 1 diabetes (T1D) genetic risk factors on the transition through preclinical stages of T1D. METHODS: In TrialNet participants who have been genotyped with the TEDDY-T1DExomeChip array (Illumina HumanCoreExome Beadarray with custom content), we…
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Validating and Leveraging Non-SARS-CoV-2 Respiratory Infection as a Negative Control Outcome in a Phase 3 COVID-19 Vaccine Trial with Extended Observational Follow-Up
Negative control outcomes (NCOs) are useful tools for hidden bias detection, but empirical evidence validating NCOs for COVID-19 is lacking. To address this gap, we examined the blinded phase of the randomized, placebo-controlled Coronavirus Vaccine Efficacy (COVE; NCT04470427) trial of the…
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MRI characteristics during attack and remission distinguish patients with MOG-antibody associated disease from multiple sclerosis
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and multiple sclerosis (MS) have both overlapping and distinct MRI lesion features which vary with imaging timing. This study identified distinguishing MRI characteristics using paired MRIs at clinical attack and…
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Evaluation of a Distribution, Education, and Awareness Intervention for Child Passenger Safety in Lebanon – a Low- and Middle-Income Country Setting
BACKGROUND: The Eastern Mediterranean Region suffers disproportionately from pediatric traffic-related injuries. Despite governmental laws, Lebanon – an eastern Mediterranean country – has low child restraint (CR) use prevalence. This study examined the impact of utilizing car seat Distribution…
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HIV and syphilis coinfection in pregnancy and adverse birth outcomes in Uganda
BACKGROUND. Despite increasing syphilis incidence worldwide, little is known about the combined impact of maternal HIV and syphilis coinfection. We determined effects of HIV/syphilis coinfection in pregnancy on birth outcomes. METHODS. We conducted two prospective birth cohort studies of pregnant…
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Artikel Jurnal Teks lengkap
Urinary tobacco and nicotine exposure biomarkers as predictors of transitions between cigarette and e-cigarette use in the Exhale longitudinal cohort study
INTRODUCTION: Urinary tobacco and nicotine exposure biomarkers may be predictive of subsequent transitions in product use. METHODS: We used data from an observational study of 371 adults who smoked cigarettes daily, some of whom also used e-cigarettes, and who were followed every two months for up…
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Artikel Jurnal Teks lengkap
Evaluation of [(11)C]CS1P1 in Healthy Young and Older Adults
BACKGROUND AND PURPOSE: Sphingosine-1-phosphate receptor 1 (S1PR1) is a key regulator of neuroinflammation and plays a crucial role in multiple neurodegenerative diseases. [(11)C]CS1P1 is a novel PET tracer for measuring expression levels of S1PR1 in humans. Before widespread application, its…
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Artikel Jurnal Teks lengkap
Clinical consequences of delaying implementation of long-acting antiretroviral therapy for people with HIV and persistent viremia in the US
BACKGROUND: People with HIV (PWH) with persistent viremia and adherence challenges to oral antiretroviral therapy (ART) can achieve viral suppression (VS) with long-acting cabotegravir/rilpivirine (LA-CAB/RPV). US guidelines, however, recommend CAB/RPV only in limited situations. We projected the…
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Artikel Jurnal Teks lengkap
Performance of Ulcer Features in Predicting Malignancy among Gastric Ulcers Diagnosed on Upper Endoscopy
BACKGROUND/GOALS: Even though the prevalence of malignancy within gastric ulcers is low, surveillance endoscopy is routinely performed after gastric ulcer diagnosis resulting in unnecessary costs and risks. Endoscopic appearance may be used to identify ulcers with malignant features and guide…
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Artikel Jurnal Teks lengkap
Large-Scale Field Experiments on Enhancing In-Situ Burning with Fire Whirls
Fire whirls, a combustion-intensifying phenomenon, offer potential for cleaner, more efficient burns with reduced emissions in environmental applications like oil spill remediation. While most knowledge of fire whirls stems from laboratory-scale experiments, and only a limited subset of these…
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