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Mycobacterium tuberculosis-specific blood immune signatures distinguish sarcoidosis from tuberculosis disease
Sarcoidosis is a granulomatous systemic inflammatory disease predominantly affecting the lungs. It shares histopathological, clinical, and immune features with tuberculosis (TB). There are currently no diagnostic tests to formally identify sarcoidosis; instead, there is a need first to rule out the…
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Moving together to facilitate equity and inclusion in research. The co-production of interventions for clinical trials to facilitate participation of people from ethnically diverse communities
BACKGROUND: People from ethnically diverse backgrounds are underrepresented in clinical trials, reinforcing healthcare inequity. Co-production involves users of research (knowledge users) as partners in the research process. A premise of co-production is that it enhances ethicality of research by…
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Distribution and shared evolutionary history of the Fumonisin and AAL toxin biosynthetic gene clusters
BACKGROUND: Fumonisins are among the mycotoxins of most concern to food safety and are structurally similar to AAL toxins, a family of host selective toxins. Together, these two toxin families are produced by ecologically diverse species in three fungal classes: AAL toxins by Alternaria arborescens…
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Predictors of non-compliance with post-procedure follow-up after endoscopic stent placement
BACKGROUND AND STUDY AIMS: Delay or absence of follow-up after luminal or pancreatobiliary stent placement can lead to adverse events. Few studies have investigated patient factors that impact compliance. The aim of this study was to identify patient-related predictors of compliance and…
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Therapeutic efficacy of dihydroartemisinin-piperaquine and artesunate-pyronaridine combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Ghana, 2023
INTRODUCTION: Malaria case management in Ghana is a key intervention within the national malaria elimination agenda. Currently, artesunate-amodiaquine (AS-AQ), artemetherlumefantrine (AL), and artesunate-pyronaridine (AP) are the first-line medicines for treating uncomplicated malaria whilst…
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Genetic Landscape of Oral Cavity Squamous Cell Carcinoma
OBJECTIVE: The association, if any, between gene mutations, pathologic features of squamous cell carcinoma of the head and neck, and patient prognosis is unknown. This study investigates the association between common gene mutations in oral cavity squamous cell carcinoma, pathologic features of…
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Update of the Xylella spp. host plant database – Systematic literature search up to 30 June 2025
This scientific report provides an update of the Xylella spp. host plant database, aiming to provide information and scientific support to risk assessors, risk managers and researchers dealing with Xylella spp. Upon a mandate of the European Commission, EFSA created and regularly updates a database…
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Development and validation of a clinical model for predicting 90-day outcomes after endovascular therapy with adjunctive tirofiban in acute ischemic stroke
BACKGROUND: Endovascular therapy (EVT) represents a cornerstone in the treatment of acute ischemic stroke due to large vessel occlusion (AIS-LVO). Despite high recanalization rates, ineffective microcirculatory reperfusion and early reocclusion can compromise clinical outcomes. The adjunctive use…
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Outcomes of total hip arthroplasty in obese patients with and without preoperative weight loss: A systematic review and meta‐analysis
PURPOSE: Obesity is often considered a relative contraindication to total hip arthroplasty (THA) due to presumed increased perioperative and postoperative risk. Consequently, obese patients are often advised to lose weight prior to THA. However, the effect of preoperative weight loss on THA…
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Population structure, regions of homozygosity (ROH) and selection signal of two domesitic goat breeds revealed by whole-genome resequencing
BACKGROUND: Chinese indigenous goat breeds exhibit rich genetic diversity and a long history of domestication, endowing these native populations with superior traits in environmental adaptation, forage utilization, and disease resistance. The identification of selection signatures through…
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APM⁺ macrophages associated with plaque vulnerability via MIF–CD74 signaling: a multi-omics study
BACKGROUND: Atherosclerosis (AS) is a chronic vascular disease and the principal cause leading to ischemic cardiomyopathy (ICM). It involves complex metabolic dysregulation beyond the resolution of single-omics. Emerging evidence implicates arginine-proline metabolism (APM) in driving inflammation…
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Methodological and statistical errors distort the effects of glucagon-like peptide-1 receptor agonist drugs on body composition in patients with type 2 diabetes mellitus
In August of 2025, Wang and colleagues published a systematic review and meta-analysis quantifying the effects of glucagon-like peptide-1 receptor agonist (GLP1RA) drugs on skeletal muscle mass in patients with type 2 diabetes mellitus. This paper is of considerable clinical importance, as…
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Targeted questionnaires improve detection of early gastrointestinal symptoms in young children with Fabry disease
BACKGROUND: Fabry disease (FD) is a multisystemic, progressive, X-linked genetic disorder caused by dysfunction of the enzyme α-galactosidase A. Symptoms commonly present in childhood in classic patients. Prior studies in classic patients suggest primary presenting features include gastrointestinal…
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Domestic violence’s impact on maternal–child relationship and child behavior: a nursing study from Egypt
BACKGROUND: Domestic violence is a global public health concern that negatively affects maternal mental health, parent–child relationships, and child behavioral outcomes. Attachment theory suggests that disruptions in maternal sensitivity and caregiving due to violence can compromise children’s…
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GuREx-MIH: cost-effectiveness analysis of extraction versus restorative treatment for first permanent molars affected by Molar-Incisor Hypomineralisation in 11-year-old Swedish children
BACKGROUND: The aim of this study was to evaluate the cost-effectiveness of extraction compared with restorative treatment of first permanent molars (FPMs) affected by Molar–Incisor Hypomineralisation (MIH) in 11-year-olds in Sweden. METHODS: Seventy-five patients from the GuREx-MIH project were…
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Determinants of academic performance among medical students in Egypt: a multi-center cross-sectional study
BACKGROUND: Academic performance is a critical determinant of career opportunities for medical students. This study aimed to identify the socio-demographic, institutional, and social factors associated with academic achievement among medical students across Egypt's diverse university systems…
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Parent and caregiver perceptions of cannabidiol products may put children at risk for unintentional exposure
OBJECTIVES: Rapid growth in the cannabidiol (CBD) market has been temporally associated with increasing emergency department (ED) visits related to cannabis exposure in young children. This study examined the prevalence of CBD products among individuals with and without children in the household…
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Change in maternal income status following stillbirth, neonatal death and severe neonatal morbidity
AIM: We evaluated whether stillbirth, neonatal death or severe neonatal morbidity is associated with a mother’s change in residential neighbourhood income between two consecutive births. METHODS: This population-based cohort included all mothers in Ontario, Canada with two consecutive births at…
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