11.943.971 hasil
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Artikel Jurnal Teks lengkap
Country governance of antimicrobial resistance (AMR) surveillance: observations on global progress and aid programme effectiveness using data from the Tracking AMR Country Self-Assessment Survey (TrACSS)
BACKGROUND: AMR is an important global public health challenge, but there is a lack of good data on response progress. This study addresses country governance of antimicrobial resistance (AMR) surveillance, considering changes in responses to the Tracking Antimicrobial Resistance Country…
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Mapping the patient journey of adult patients with Spinal Muscular Atrophy in Greece: key challenges and priorities for action
BACKGROUND: Spinal Muscular Atrophy (SMA) carries a heavy burden for patients and caregivers, which, in Greece, is exacerbated by resource constraints and limited care integration. To-date, there were only anecdotal descriptions of - mostly pediatric - SMA patient journey challenges. This survey…
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Temperature alters interactions and keystone taxa in the marine microbiome
Marine microbes shape global biogeochemical cycles and marine food webs. Although biotic interactions underpin microbial community dynamics, most interactions between wild marine microbes are unknown. Here, we used empirical dynamic modeling to examine a six-year record of coastal microbial…
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Single-cell transcriptome analysis reveals mechanisms by which hippocampal deep brain stimulation promotes neurorepair and microglial subpopulation remodeling in ischemic stroke
BACKGROUND: In patients with ischemic stroke, the hippocampus is one of the most severely damaged regions of the brain; however, the optimal parameters for hippocampal deep brain stimulation in these patients remain unknown. The underlying mechanism of hippocampal deep brain stimulation in the…
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Evaluation of the efficacy of optical genome mapping in prenatal diagnosis: a retrospective cohort study
BACKGROUND: Optical genome mapping (OGM) is an emerging cytogenetic method for concurrently detecting structural variants (SVs) and copy number variants (CNVs). However, its clinical application in prenatal diagnosis remains underexplored. METHODS: This study retrospectively evaluated the clinical…
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Trajectories of adiposity indices and the risk of cardiovascular disease and mortality: a prospective cohort study
BACKGROUND: While novel adiposity indices such as the body roundness index (BRI), a body shape index (ABSI), the visceral adiposity index (VAI), and the Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) index outperform body mass index (BMI) in predicting cardiovascular disease…
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Estimating the prevalence of Echinococcus spp. in a Tibetan fox (Vulpes ferrilata) population on the eastern Tibetan Plateau
BACKGROUND: The Tibetan fox (Vulpes ferrilata) is a crucial wild definitive host of Echinococcus cestodes on the Tibetan Plateau. Fecal detection of Echinococcus DNA (fecal prevalence) is commonly used to estimate Echinococcus spp. prevalence in canine populations (population prevalence). However…
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Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction
BACKGROUND: Despite therapeutic advances, atherosclerosis remains a major global health challenge. Most current treatments target systemic risk factors rather than the diseased vascular wall. Our previous work identified genistein, a soy isoflavone, as a cannabinoid receptor 1 (CB1) antagonist…
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Management of Suspected Stage IVA Endometrial Cancer With Rectosigmoid Involvement Using Neoadjuvant Chemotherapy and Interval Surgery
Stage IVA endometrial cancer with rectosigmoid involvement is rare and presents challenges for primary surgical management due to the risk of major multivisceral resection and associated morbidity. We report the case of a 55-year-old woman who presented with prolonged postmenopausal bleeding…
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Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries
BACKGROUND: The 7–1–7 targets are gaining traction as measurable targets for assessing a country’s readiness to detect and respond to outbreaks of infectious diseases. The targets are outbreak detection within 7 days of emergence, notification to health authorities within 1 day, and key early…
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Artikel Jurnal Teks lengkap
Comment for conflict and health don't let sexual and reproductive health in humanitarian and fragile settings become a casualty of aid cuts and crisis fatigue
In 2025, 300 million people require humanitarian assistance, with sexual and reproductive health (SRH) crises driving 60% of preventable maternal deaths in conflict-affected countries. Despite the proven life-saving impact of the Minimum Initial Service Package (MISP) for SRH in Crisis Situations…
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Theorising the politics of famine: Bangladesh in 1974
1974 saw the first—and last—famine in independent Bangladesh. The disaster killed an estimated two per cent of the population and caused a crisis of legitimacy for the leadership of a nation that had won its independence only three years previously. Its catastrophic aftermath saw the emergence of…
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Integrated Genomic and Epidemiological Surveillance to Monitor SARS‐CoV‐2 Variants in Italy: Insights From the JN.1 Case Study (2023–2024)
The epidemiology of SARS‐CoV‐2 is marked by the continuous emergence of new lineages. Early detection and assessment of their transmissibility can be challenging for surveillance systems that rely solely on case time series data. Genomic surveillance, focusing on identifying and characterizing…
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Novel way of displaying Delphi responses when collecting through the REDCap data collection system
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Artikel Jurnal Teks lengkap
The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life
Anxious temperament (AT) is a nonhuman primate phenotype that models childhood behavioral inhibition, a prominent risk factor for anxiety disorders and stress‐related psychopathology. To understand its earliest antecedents, we characterized AT's developmental trajectory over the first year of life…
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Rethinking the Origins of Cross‐Language Effects: How Heard Verbs Influence Japanese‐ and English‐Speaking Children's Attention to the Details of Actions
Languages differ in how words carve up the world into categories, and these differences in lexical categories often influence how speakers interpret perceived events. Past research has shown that languages with a single and general word for one domain tend to cue attention more broadly than…
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Challenges encountered in managing tuberculosis in children: a case report
BACKGROUND: The management of pediatric tuberculosis involves several challenges, as illustrated in these three cases. Challenges are numerous and each case demonstrates the difficulty and delay in diagnosis, social constraints that delay the diagnosis, and drug dosing schedules that cause serious…
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Artikel Jurnal Teks lengkap
Integrative transcriptomic profiling reveals subtype-specific therapeutic vulnerabilities and resistance mechanisms in prostate cancer
OBJECTIVE: Advanced prostate cancer (PCa) remains therapeutically challenging due to heterogeneous mechanisms of resistance to androgen receptor (AR)-targeting agents. While AR signaling persists in castration-resistant PCa (CRPC), emerging evidence suggests AR-independent survival pathways may…
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Artikel Jurnal Teks lengkap
Notes about me, without me: Research about me, without me
BACKGROUND: In mental health services, documentation is dominated by providers who write clinical notes without the input of the individuals accessing the services. Although these notes are essential, they often exclude the voices and perspectives of those accessing services. We suggest that this…
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