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3 results for "Hannu Larjava"

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  1. Journal Article Full text

    Expression and Function of Connexin 43 in Human Gingival Wound Healing and Fibroblasts

    Rana Tarzemany; Guoqiao Jiang; Hannu Larjava et al.

    PLOS ONE, Vol. 10 No. 1 · 2015 · English · PLOS Scopus

    Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression or…

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  2. Journal Article Full text

    Human Gingival Fibroblasts Display a Non-Fibrotic Phenotype Distinct from Skin Fibroblasts in Three-Dimensional Cultures

    Wesley Mah; Guoqiao Jiang; Dylan Olver et al.

    PLoS ONE, Vol. 9 No. 3 · 2014 · English · PLOS Scopus

    Scar formation following skin injury can be a major psychosocial and physiological problem. However, the mechanisms of scar formation are still not completely understood. Previous studies have shown that wound healing in oral mucosa is faster, associates with a reduced inflammatory response and…

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  3. Journal Article Full text

    Melanoma-Associated Cancer-Testis Antigen 16 (CT16) Regulates the Expression of Apoptotic and Antiapoptotic Genes and Promotes Cell Survival

    Camilla Nylund; Pekka Rappu; Eveliina Pakula et al.

    Public Library of Science · 2012 · English · PLOS Scopus

    Cancer-testis (CT) antigens are predominantly expressed in testis or placenta, but absent in most adult tissues. During malignant transformation CT genes are often activated. CT antigen 16 (CT16, PAGE5) is frequently expressed in advanced melanoma but its biological function has been unknown. To…

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