12 results for "Rahman, Mahbuba"
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Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine
Medical imaging is an important factor for diagnosis. It can be used to diagnose patients, differentiate disease stages, and monitor treatment regimens. Although different imaging technologies are available, MRI is sensitive over other imaging modalities as it is capable of deep tissue penetration…
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Editorial: design considerations for future personalized vaccination approaches
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Metabolomics of infectious diseases in the era of personalized medicine
Infectious diseases continue to be a major cause of morbidity and mortality worldwide. Diseases cause perturbation of the host’s immune system provoking a response that involves genes, proteins and metabolites. While genes are regulated by epigenetic or other host factors, proteins can undergo…
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Metabolomics in Infectious Diseases and Vaccine Response: Insights into Neglected Tropical and Non-Neglected Pathogens
Background/objectives: Metabolomics has emerged as a powerful systems-biology tool for deciphering dynamic metabolic alterations occurring during infectious diseases and following vaccination. While genomics and proteomics provide extensive molecular and regulatory information, metabolomics…
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Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease
INTRODUCTION: Coronary artery disease (CAD) is a major global cause of morbidity and mortality. Therefore, advances in early identification and individualized treatment plans are crucial. METHODS: This article presents machine learning (ML) based model that can recognize metabolomic compounds…
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Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens
Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic, unbiased approach to explore the relative…
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Regional and Longitudinal Dynamics of Cyanobacterial Blooms/Cyanobiome and Cyanotoxin Production in the Great Lakes Area
Cyanobacteria (blue-green algae) are a diverse group of prokaryotic microorganisms that impact global biogeochemical cycles. Under eutrophic conditions, cyanobacterial species can produce cyanotoxins, resulting in harmful algal blooms (cHABs) that degrade water quality and result in economic and…
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A non-canonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling
Interleukin-1 receptor (IL-1R)-associated kinases (IRAKs) are core effectors of Toll-like receptors (TLRs) and IL-1R in innate immunity. Here, we found that IRAK4 and IRAK1 together inhibit DNA damage-induced cell death independently of TLR/IL-1R signaling. In human cancer cells exposed to…
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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling
T follicular helper (Tfh) cells abundantly express the immunoreceptor PD-1, and the impact of PD-1 deficiency on antibody (Ab)-mediated immunity in mice is associated with compromised Tfh cell functions. Here, we examined the role of the PD-1:PD-L1 axis on Ab-mediated immunity. Individuals with…
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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1…