3 hasil untuk "Adrian Woolfson"

The Hedgehog Pathway as a Therapeutic Target in Chronic Myeloid Leukemia

Andrew Wu; Kelly A. Turner; Adrian Woolfson dkk.

Pharmaceutics, Vol. 15 No. 3 · 2023 · Inggris · DOAJ Scopus

Despite the development of therapeutic agents that selectively target cancer cells, relapse driven by acquired drug resistance and resulting treatment failure remains a significant issue. The highly conserved Hedgehog (HH) signaling pathway performs multiple roles in both development and tissue…

Targeting the Chronic Myeloid Leukemia Stem Cell: A Paradigm for the Curative Treatment of Human Malignancies

Adrian Woolfson; Xiaoyan Jiang

Myeloid Leukemia - Basic Mechanisms of Leukemogenesis · 2011 · Inggris · IntechOpen

Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences

Simeon. D. Castle; Thea C. T. Irvine; Adrian Woolfson dkk.

Nature Communications, Vol. 17 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract DNA polymerases are complex molecular machines capable of replicating genetic material using a template-driven process. While the copying function of these enzymes is well established, their ability to perform untemplated DNA synthesis is less well characterized. Here, we explore the…