5 results for "Amresh Kumar"
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Phase 1, randomized, crossover study comparing intravenous GTX-104 to oral nimodipine in healthy human subjects
Enterally-administered nimodipine is the only approved drug formulation available in the United States for treatment of patients with aneurysmal subarachnoid hemorrhage. Intravenous nimodipine is available in other countries but it contains a high concentration of ethanol that is irritating to the…
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A mixed-method study to improve outcome of mass drug administration in two TAS failed districts of Uttar Pradesh, India
Lymphatic filariasis (LF), commonly called “elephantiasis,” is one of the leading causes of disability around the world, with approximately 863 million people across 47 countries still living under threat of LF infection. India, with 40% of the global LF burden, is the most affected country that…
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Relationship between treatment regimens for visceral leishmaniasis and development of post-kala-azar dermal leishmaniasis and visceral leishmaniasis relapse: A cohort study from Bangladesh
Background: We investigated the relationship of treatment regimens for visceral leishmaniasis (VL) with post-kala-azar dermal leishmaniasis (PKDL) and visceral leishmaniasis relapse (VLR) development. Methods: Study subjects included cohorts of patients cured of VL since treatment with monotherapy…
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Healthcare provider perspectives on delivering next generation rotavirus vaccines in five low-to-middle-income countries
Background: Live oral rotavirus vaccines (LORVs) have significantly reduced rotavirus hospitalizations and deaths worldwide. However, LORVs are less effective in low- and middle-income countries (LMICs). Next-generation rotavirus vaccines (NGRVs) may be more effective but require administration by…
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Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in Bangladesh
Background: This study was conducted in Bangladeshi patients in an outpatient setting to support registration of Paromomycin Intramuscular Injection (PMIM) as a low-cost treatment option in Bangladesh. Methodology: This Phase IIIb, open-label, multi-center, single-arm trial assessed the efficacy…