5 results for "Athanasios Stavropoulos"

TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K–S6RP proteins

Athanasios Stavropoulos; Vassiliki Stamatopoulou; Eleftherios Pavlos et al.

Cellular & Molecular Biology Letters, Vol. 31 No. 1 · 2026 · English · DOAJ Scopus

Abstract Background Transforming growth factor-beta (TGFβ)-superfamily signaling has been implicated in the regulation of hepatocyte growth and regeneration after acute or chronic liver injury. However, the precise mechanisms underlying TGFβ signaling in the distinct hepatic cell types during the…

Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair

Alexandros Sountoulidis; Athanasios Stavropoulos; Stavros Giaglis et al.

Public Library of Science · 2012 · English · PLOS Scopus

Signaling by Bone Morphogenetic Proteins (BMP) has been implicated in early lung development, adult lung homeostasis and tissue-injury repair. However, the precise mechanism of action and the spatio-temporal pattern of BMP-signaling during these processes remains inadequately described. To address…

Also available at: DOAJ

In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-synucleinopathies

Maria Fouka; Iraklis Tsakogias; Elena-Georgia Gialinaki et al.

Acta Neuropathologica Communications, Vol. 13 No. 1 · 2025 · English · DOAJ Scopus

Abstract Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (aSyn) aggregates in specific brain regions, which are likely to be the disease-causing entities. Herein, we employed novel, systemically administered, brain-penetrating viral vectors (PHP.eB AAVs) in order to…

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

Maximilianos Elkouris; Haroula Kontaki; Athanasios Stavropoulos et al.

Cell Reports, Vol. 15 No. 12 · 2016 · English · DOAJ Scopus

TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis, differentiation, immune responses, and fibrogenesis. Here, we describe a lysine methylation-mediated mechanism that controls the pro-fibrogenic activity of TGF-β. We find that the methyltransferase Set9…