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Cell Reports
Scopus
ISSN 2211-1247 · Elsevier · 12,581 articles in the index
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Journal Article
METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy
Summary: The role of neurotransmitters in suppressing anti-tumor immunity has garnered increasing attention. While glutamate has been extensively studied in neurological diseases, its potential role in regulating anti-tumor immunity, particularly in the context of neoadjuvant immunochemotherapy…
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Journal Article
α-Ketoglutarate couples cellular metabolism to developmental growth via hydroxylation-dependent degradation of Yorkie
Summary: The evolutionarily conserved Hippo signaling pathway, essential for development and tissue homeostasis, is intimately linked to cellular metabolism. While cellular α-ketoglutarate (α-KG) levels fluctuate with metabolic state, the functional significance of these fluctuations for…
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Journal Article
Immunoglobulin A-producing cells mediate the clinical benefits of metformin via interleukin-10
Summary: Metformin (MTF) is the primary treatment for type 2 diabetes, but its mechanisms for enhancing insulin sensitivity require thorough exploration. This study revealed that MTF improves insulin sensitivity by promoting the proliferation and translocation of immunoglobulin A…
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Journal Article
Controlled pyroptosis of engineered macrophages enables biphasic antitumor via the release of oncolytic bacteria and inflammatory signals
Summary: Engineered macrophage-based therapies offer promising potential for cancer treatment but are limited by slow, uncontrolled drug release and the risk of macrophage reprogramming into tumor-promoting phenotypes. Here, we developed a thermally induced macrophage autolysis release system, the…
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Journal Article
Ccl12 coordinates immune-neural crosstalk to promote adipose sympathetic remodeling after burn trauma
Summary: Burn injury triggers sustained white adipose tissue (WAT) remodeling and hypermetabolism. While systemic catecholamines are considered primary drivers of this response, local mechanisms remain poorly defined. Here, we identify an intra-fat immune-neural axis that drives sympathetic…
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Journal Article
Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus
Summary: The hypothalamus contains multiple regions, including the ventromedial hypothalamus (VMH) and arcuate (ARC), which are responsible for sex-differentiated functions such as endocrine signaling, metabolism, and reproductive behaviors. While molecular, anatomic, and sex-differentiated…
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Journal Article
Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques
Summary: Broadly neutralizing antibodies (bNAbs) targeting multiple sites of HIV-1 Env vulnerability can be induced by infection, but simultaneous elicitation of bNAbs against multiple epitopes has not been achieved by vaccination. In this study, we designed a dual-epitope vaccine targeting both…
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Journal Article
Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood
Summary: Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been associated with the development of aging-associated diseases. However, it remains unknown whether low NAD+ levels in early life affect aging. This study demonstrates that deficiency of NAD synthetase (NADS), a…
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Journal Article
Norepinephrine acts through radial astrocytes in the developing optic tectum to enhance threat detection and escape behavior
Summary: The ability to switch behavioral states is essential for animals to adapt and survive. Here, we demonstrate how norepinephrine (NE) activation of radial astrocytes alters visual processing in the optic tectum (OT) of developing Xenopus laevis. NE activates calcium transients in radial…
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Journal Article
ATP7B-maintained copper stores in myeloid progenitors are required for functional maturation of neutrophils
Summary: Copper (Cu) is essential for innate immunity; however, how neutrophils regulate Cu homeostasis to support their functions remains unclear. We found that myeloid progenitors express abundant Cu-transporter ATP7B targeted to distinct vesicles and store Cu in vesicles. During neutrophil…
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Journal Article
Activation status of astrocytes drives the MS/NMOSD therapeutic paradox: Insights from IFNAR1 signaling
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disease of the central nervous system (CNS) that, despite overlapping phenotypic features with multiple sclerosis (MS), manifests with more severe clinical outcomes. The defining pathogenic driver of NMOSD is…
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Journal Article
SARS-CoV-2 fusion-peptide-directed antibodies are elicited by natural infection and can mediate broad sarbecovirus neutralization
Summary: Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. However, the development of antibodies capable of neutralizing across the Coronavirinae subfamily is poorly…
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Journal Article
Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization
Summary: Metastasis is a highly inefficient process, with the vast majority of disseminated cancer cells failing to form secondary tumors. To establish brain metastases, cancer cells must traverse the blood-brain barrier and rapidly adapt to the specialized neural microenvironment. Here, we…
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Journal Article
Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC
Summary: Metabolic dysregulation has been recognized as a crucial driver of tumorigenesis, particularly in metabolic dysfunction-associated steatotic liver disease (MASLD)-related hepatocellular carcinoma (HCC). However, the underlying mechanisms remain poorly understood. Here, we identify…
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Journal Article
Construction of individual-specific social cognitive maps in the human brain
Summary: Social interactions depend on social cognitive maps (SCMs) in the brain. We investigate how SCMs emerge during partner selection based on trial-by-trial feedback about candidates’ generosity and competence. We show that the candidates spread out in a subjective two-dimensional SCM defined…
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Journal Article
A positive feedback loop between FGR and p65 sustains satellite glial cell activation and chronic neuropathic pain
Summary: Chronic neuropathic pain is a debilitating clinical problem. Sustained activation of satellite glial cells (SGCs) in the dorsal root ganglion (DRG) contributes to neuroinflammation and persistent pain, although the underlying mechanisms driving prolonged SGC activation remain elusive…
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Journal Article
Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations
Summary: As human populations migrated to diverse geographical regions, they encountered varying pathogens, leading to pronounced natural selection pressures on the immune system. Analysis of non-synonymous single-nucleotide polymorphisms (nsSNPs) across major geographically structured populations…
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Journal Article
The BZR1-interacting WD repeat protein participates in brassinosteroid-dependent growth and stress response in tomato
Summary: Brassinosteroids (BRs) are steroidal phytohormones that play crucial roles in plant growth and resilience. The stability of BRASSINAZOLE RESISTANT 1 (BZR1), the central transcription factor of BR signaling, is controlled by the GSK3-like kinase BRASSINOSTEROID INSENSITIVE 2…
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Journal Article
HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs
Summary: HP1s are involved in the assembly of heterochromatin and transcriptional regulation. Here, we report the molecular mechanisms underlying binding of the chromoshadow domain of HP1γ (HP1γCSD) to the transcriptional co-repressor KAP1 and HP1γ self-assembly. Using crystallography, NMR, and…
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Journal Article
Hydrogen sulfide persulfidates OAS-A1 to balance cysteine levels in regulating Arabidopsis stomatal development
Summary: Plants regulate photosynthesis and transpiration primarily by adjusting the stomatal aperture and density to adapt to environmental changes. O-acetylserine(thiol)lyase (OAS-TL) maintains a balance between cysteine (Cys) and sulfide metabolism. Here, we report that OAS-TL plays a critical…
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