1 hasil untuk "B. Stephan"

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

Neha N. Parayath; Sirkka B. Stephan; Amanda L. Koehne dkk.

Nature Communications · 2020 · Inggris · OpenAlex Scopus

Engineering chimeric antigen receptors (CAR) or T cell receptors (TCR) helps create disease-specific T cells for targeted therapy, but the cost and rigor associated with manufacturing engineered T cells ex vivo can be prohibitive, so programing T cells in vivo may be a viable alternative. Here we…