67 hasil untuk "Back Michael"
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Prädiktive Antriebsregelung zum energieoptimalen Betrieb von Hybridfahrzeugen
Die in dieser Arbeit beschriebene Prädiktive Antriebsregelung nutzt Telematikinformationen für den kraftstoffoptimalen Betrieb von Hybridfahrzeugen. Es wird insbesondere die mathematische Modellbildung des Antriebsstrangs, die Prädiktion vorausliegender Fahrzustände sowie der Algorithmus zur…
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Spatial Mapping of Glioblastoma Infiltration: Diffusion Tensor Imaging-Based Radiomics and Connectomics in Recurrence Prediction
Glioblastoma (GBM) often exhibits distinct anatomical patterns of relapse after radiotherapy. Tumour cell migration along myelinated white matter tracts is a key driver of disease progression. The failure of conventional imaging to capture subclinical infiltration has driven interest in advanced…
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LARGE VOLUME RE-IRRADIATION IS A VIABLE OPTION IN PATIENTS WITH RECURRENT REFRACTORY GLIOBLASTOMA
PURPOSE: Current practice in re-irradiation (reRT) of patients with previously treated Glioblastoma (GBM) has generally been limited to small volume reRT often with stereotactic procedures. Less evidence exists for the safety, toxicity and outcomes of patients who undergo large volume reRT. This…
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Association of MRI Volume Parameters in Predicting Patient Outcome at Time of Initial Diagnosis of Glioblastoma
Purpose: Patients with glioblastoma (GBM) may demonstrate varying patterns of infiltration and relapse. Improving the ability to predict these patterns may influence the management strategies at the time of initial diagnosis. This study aims to examine the impact of the ratio (T2/T1) of the…
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Assessment of Patterns of Infiltration and Relapse of Patients with Glioblastoma of the Occipital Lobe
HIGHLIGHTS: What are the main findings? Occipital lobe glioblastoma frequently demonstrates tumour infiltration beyond the primary gyral subsite into anatomically connected brain regions. Progression commonly occurs at distant neuroanatomical sites rather than remaining confined to the original…
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RADT-25. UNDERSTANDING PATTERNS OF TUMOUR INFILTRATION IN PATIENTS WITH MULTIFOCAL GLIOBLASTOMA AND IMPACT ON SURVIVAL OUTCOMES
BACKGROUND: Multifocal glioblastoma(MF-G) are often clustered with presumed uniform worse prognosis. This study explores varying patterns of infiltration of MF-G in relation to radiological features, including presence of contiguous MRI T2-weighted abnormalities and adjacent neural tract pathway…
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RADT-32. USING NEUROANATOMICAL SUBSITE TO PREDICT PATTERNS OF GLIOBLASTOMA INFILTRATION: POTENTIAL FOR INDIVIDUALISING RADIATION THERAPY TARGET VOLUME DELINEATION OF THE PARIETAL AND POSTERIOR FRONTAL REGIONS
BACKGROUND: Radiation therapy(IMRT) protocols for glioblastoma utilize isotropic margin expansion around neurosurgical cavities/residual contrast enhancing(T1gd) disease. However pathways of infiltration may be associated with white matter tract(WMT) involvement varying between neuroanatomical…
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PATTERNS OF INfiLTRATION AND RELAPSE OF GLIOBLASTOMA INVOLVING THE ANTERIOR TEMPORAL LOBE: IMPLICATIONS FOR RADIATION THERAPY TARGET VOLUME DELINEATION
AIMS: To characterise specific patterns of infiltration and recurrence for IDH-wildtype Glioblastoma (GBMwt) involving the anterior temporal lobe (ATL) METHOD: Patients managed for GBMwt involving ATL between 1/2008-12/2020 were identified. Tumour was segmentated on T1-gadolinium-enhanced(T1gd) and…
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A customized allogenic bone block for alveolar reconstruction quantitated by a 3D matching technique: A case report
After initial resorption, the bone volume showed long‐term stability following loading of the implant. Furthermore, 3D matching was a suitable quantification method to analyze the volume development of bone augmentation.
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Efficacy and volume stability of a customized allogeneic bone block for the reconstruction of advanced alveolar ridge deficiencies at the anterior maxillary region: a retrospective radiographic evaluation
OBJECTIVES: The aim of this retrospective case series was to evaluate the efficacy and volume stability of a customized allogeneic bone block (CABB) for the hard tissue reconstruction of severely atrophied anterior maxillary ridges. MATERIALS AND METHODS: Hard tissue alterations between baseline…
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Volumetric Response of Limited Brain Metastatic Disease to Focal Hypofractionated Radiation Therapy
Background: This is a retrospective study aimed at assessing the volumetric response, morbidity and failure rates of hypofractionated radiation therapy (HFRT) for definitive focal management of limited brain metastasis. Methods: Patients managed with HFRT for unresected limited metastatic (≤10…
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An ultrasonographic evaluation of skin thickness in breast cancer patients after postmastectomy radiation therapy
Abstract Background To determine the usefulness of ultrasonography in the assessment of post radiotherapy skin changes in postmastectomy breast cancer patients. Methods Patients treated for postmastectomy radiotherapy in National University Hospital (NUH) and Tan Tock Seng Hospital (TTSH)…
Juga tersedia di: DOAJ, PubMed Central
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Large volume re-irradiation with bevacizumab is a feasible salvage option for patients with refractory high-grade glioma
BACKGROUND: Clinical studies of re-irradiation (ReRT) for relapsed high-grade glioma (HGG) have generally reported the use of small volume ReRT techniques such as stereotactic radiosurgery in selected patients with isolated focal relapse. This study reports the outcome with large-volume ReRT to…
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Radiation, inflammation and the immune response in cancer
Radiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the impact of radiation on tumour morphology is routinely examined in the pre-clinical and clinical setting, the impact of radiation on the tumour…
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Role of delayed salvage bevacizumab at symptomatic progression of chemorefractory glioblastoma
BACKGROUND: Assess benefit of salvage bevacizumab (BEV) at time of symptomatic progression in patients with refractory glioblastoma (GBM). METHODS: Patients managed with adjuvant long course chemo-radiation therapy for GBM were entered into a prospective database. At chemorefractory symptomatic…
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Predicting patterns of failure in temporal lobe GBMs: possible implications on radiotherapy treatment portals
BACKGROUND: Characterise patterns of failure of Temporal Lobe (TL) Glioblastoma (GBM) following treatment with relation to normal temporal lobe anatomy and neural pathways. METHODS: 335 GBM patients received radiotherapy between 03/2007 and 07/2014, 100 were located in TL. Site of initial tumour…
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EFFECTIVENESS OF BEVACIZUMAB TO MANAGE SYMPTOMATIC STEROID REFRACTORY PSEUDOPROGRESSION OCCURRING DURING OR EARLY FOLLOWING RADIATION THERAPY FOR GLIOBLASTOMA
AIMS: Approximately 15% of patients with glioblastoma (GBM) managed with Stupp Protocol(Stupp60Gy), experience symptomatic steroid-refractory mass effects from pseudoprogression resulting in significant morbidity. Beva- cizumab (BEV) potentially produces a clinical response allowing corticosteroid…