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Radiation Oncology
Scopus
ISSN 1748-717X · BMC · 2.839 artikel di indeks
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Artikel Jurnal
Definitive single-fraction ablative radiotherapy for early-stage breast cancer: DESERT-I trial – a dose-escalation study protocol
Abstract Background There is a growing trend toward more tolerable and less aggressive treatments for breast cancer patients. For low-risk patients, accelerated partial breast irradiation (APBI) following conservative surgery is a widely used treatment. However, partly due to the development of…
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Artikel Jurnal
Integrating static angle ports and dynamic collimator rotation in volumetric modulated arc therapy for hypofractionated whole breast irradiation in Chinese females: a single-centre dosimetric study
Abstract Background Whole breast irradiation remains the standard in breast-conserving therapy for early-stage carcinoma. Conventional RapidArc™ plans, while dosimetrically efficient, are limited by fixed collimator position. This often leads to unnecessary irradiation to adjacent organs at risk…
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Artikel Jurnal
Comparison of radiation-induced temporal lobe injury after helical tomotherapy versus conventional intensity-modulated radiotherapy for nasopharyngeal carcinoma: a propensity score-matched cohort study
Abstract Purpose To compare the incidence of radiation-induced temporal lobe injury (TLI) between helical tomotherapy (HT) and conventional intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). Methods We retrospectively reviewed the medical records of NPC…
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Artikel Jurnal
Case reports that high-dose-rate brachytherapy using custom-designed mouthpiece mold for early-stage squamous cell carcinoma of the hard palate is useful
Abstract Background Surgery is the primary therapy for hard palate cancer, but this sometime worsens oral function and unavailable for patients with several comorbidities. Radiotherapy represents an alternative curative treatment option to preserve oral function, however, there are few reports on…
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Artikel Jurnal
Postoperative recurrence patterns and anatomy-stratified clinical target volume delineation in pancreatic cancer
Abstract Objectives This study aims to characterize postoperative recurrence patterns and anatomical distribution in patients with pancreatic cancer within the framework of extrapancreatic neural tract anatomy. Based on the observed recurrence sites, we propose stratified clinical target volume…
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Artikel Jurnal
Stereotactic radiosurgery for brain metastases: multistate and competing risk models of progression and survival from a single-centre 11-year experience
Abstract Background The diagnosis of brain metastases has risen due to advances in systemic treatments prolonging survival and the use of MRI. Whilst surgical resection remains a valuable mean of acutely alleviating raised intracranial pressure, reducing seizure risk, and preventing progression of…
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Artikel Jurnal
The effect of timing of post-operative radiation on outcomes in anaplastic thyroid cancer
Abstract Background Anaplastic thyroid cancer is an aggressive malignancy, for which prompt treatment is necessary. Surgical resection is the recommended initial treatment for resectable cases and most patients require postoperative radiation therapy (PORT). NCCN Guidelines state that adjuvant…
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Artikel Jurnal
Comparison of heart-sparing radiation techniques for left-sided breast cancer: DIBH combined with tangential 3D radiation vs. conventional and tangential VMAT techniques
Abstract Background Adjuvant radiotherapy after breast-conserving surgery reduces local recurrence and improves survival in breast cancer. For left-sided tumors, achieving homogeneous target coverage while minimizing dose to organs at risk (OARs), particularly the heart and ipsilateral lung…
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Artikel Jurnal
CXCR2 affects sensitization of radioresistant HPV-negative head and neck squamous cell carcinoma cells by ABT-263
Abstract Background Radiation-induced senescence strongly contributes to therapy resistance in HPV-negative head and neck squamous cell carcinoma (HNSCC). In particular, the NF- $${\rm{\kappa }}$$ B-dependent arm of the senescence-associated secretory phenotype (SASP) activates signaling pathways…
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Artikel Jurnal
Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE)
Abstract Background Radiation therapy (RT) plays a significant role in the multimodal management of primary brain tumors, improving oncological outcomes. However, despite advances such as Intensity-Modulated Radiation Therapy (IMRT), photon-based RT inevitably exposes normal organs to low-dose…
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Artikel Jurnal
A practical non-custom abdominal corset-based approach for diaphragm motion management in stereotactic body radiotherapy
Abstract Background In Stereotactic body radiation therapy (SBRT), abdominal compression devices are commonly used to manage respiratory motion. The high cost, bulky design, and low patient tolerance of these devices limit utilization. This study aimed to evaluate the impact of non-custom…
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Artikel Jurnal
Revisiting fractionation in prostate carbon ion therapy: first comparative analysis of biologically effective dose using mMKM with diverse parameters
Abstract Background Carbon ion radiotherapy (CIRT) for prostate cancer has evolved from conventional regimens [66 Gy(RBE)/20 fractions (66G20), 63 Gy(RBE)/20 fractions (63G20)] toward hypofractionated schedules [57.6 Gy(RBE)/16 fractions (57.6G16), 51.6 Gy(RBE)/12 fractions (51.6G12), and 40…
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Artikel Jurnal
Patterns of care and outcome of liver SBRT: results from a multicentre National quality project
Abstract Background Stereotactic body radiotherapy (SBRT) is applied for both primary liver tumours and liver metastases. Within a national project, we investigated patterns of care for liver SBRT and factors influencing local control (LC) and overall survival (OS). Methods Patients treated with…
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Artikel Jurnal
Refining the PTV margin determination for VMAT SBRT lung treatment through moving target dose model to account for respiratory motion uncertainty
Abstract Objective Adding a Planning Target Volume (PTV) margin remains a straightforward and effective strategy to ensure adequate target coverage under various uncertainties. Appropriately reduced margins can minimize treatment-related toxicity without compromising tumor control. However…
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Artikel Jurnal
Radiation-induced severe lymphopenia predicts distant metastasis in rectal cancer: dosimetric implications for immune-sparing radiotherapy
Abstract Background Lymphopenia is a frequent complication of pelvic radiotherapy and may impair systemic immune surveillance. This study aimed to evaluate the prognostic impact of acute severe lymphopenia (ASL) in rectal cancer and to identify dosimetric predictors relevant to immune-sparing…
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Artikel Jurnal
Magnetic resonance-guided simultaneous multi-fo cal adaptive radiotherapy for prostate, pElvis & metastases (MRgSMART-PEM) in prostate cancer: a prospective phase II study
Abstract Purpose To evaluate the safety, feasibility, and patient-reported outcomes of magnetic resonance-guided simultaneous multi-focal adaptive radiotherapy for the prostate, pelvis, and metastases (MRgSMART-PEM) in patients with high-risk, very-high-risk, or oligometastatic prostate cancer…
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Artikel Jurnal
Radiotherapy with versus without concurrent immunotherapy following neoadjuvant chemoimmunotherapy in unresectable locally advanced esophageal squamous cell carcinoma
Abstract Purpose To evaluate the impact on survival outcomes of adding concurrent immunotherapy to radiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma following neoadjuvant chemoimmunotherapy. Materials and methods We included patients with stage II–IVA…
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Artikel Jurnal
Impact of additional PRV constraint to Direct OAR robust optimization in IMPT for targets near serial organs at risk
Abstract Purpose In intensity-modulated proton therapy (IMPT), the benefit of adding planning organ-at-risk volume (PRV)-like nominal constraints to direct robust optimization for serial organs at risk remains uncertain when target-OAR separation is minimal. Using paraspinal chordoma as a model, we…
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