28 hasil untuk "Cheng PENG"
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Artikel Jurnal Teks lengkap
The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase
We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al…
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Artikel Jurnal Teks lengkap
Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease
Direct cerebral bypass is a key treatment for moyamoya disease (MMD). This surgery grafts a donor vessel onto a recipient cerebral artery to boost blood flow to hypoperfused brain regions. Unlike coronary bypass, which restores downstream flow around a blockage, cerebral bypass for MMD reverses…
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Artikel Jurnal Teks lengkap
Role of endothelial cell markers in prognosis of hepatocellular carcinoma: Integrating bioinformatics analysis and experimental validation
Background: Hepatocellular carcinoma (HCC) is a highly prevalent malignancy with poor prognosis. Endothelial cells (ECs) play a crucial role in HCC progression, yet their involvement at the single-cell level remains underexplored. This study aimed to identify ECs-specific markers and develop a…
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Artikel Jurnal Teks lengkap
Soil fungal biodiversity and pathogen identification of rotten disease in Aconitum carmichaelii (Fuzi) roots
Aconitum carmichaelii, commonly known as Fuzi, is a typical traditional Chinese medicine (TCM) herb that has been grown for more than one thousand years in China. Although root rot disease has been seriously threatening this crop in recent years, few studies have investigated root rot disease in…
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Artikel Jurnal Teks lengkap
Association between waist circumference and sleep disorder in the elderly: Based on the NHANES 2005–2018
The existing data do not consistently support the link between elderly adults’ waist circumferences and sleep disorders. This study aimed to evaluate whether waist circumference was connected with sleep disorder in the elderly. This cross-sectional study utilized data from the 2005–2018 National…
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Artikel Jurnal Teks lengkap
Therapeutic Effects of Liposome-Enveloped Ligusticum chuanxiong Essential Oil on Hypertrophic Scars in the Rabbit Ear Model
Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of fibroblasts and excessive deposition of collagen. Although treatment with surgical excision or steroid hormones can modify the symptoms, numerous treatment-related complications have been…
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Artikel Jurnal Teks lengkap
Wnt Signaling Cross-Talks with JH Signaling by Suppressing Met and gce Expression
Juvenile hormone (JH) plays key roles in controlling insect growth and metamorphosis. However, relatively little is known about the JH signaling pathways. Until recent years, increasing evidence has suggested that JH modulates the action of 20-hydroxyecdysone (20E) by regulating expression of broad…
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Artikel Jurnal Teks lengkap
Utility and Limitations of Using Gene Expression Data to Identify Functional Associations
Gene co-expression has been widely used to hypothesize gene function through guilt-by association. However, it is not clear to what degree co-expression is informative, whether it can be applied to genes involved in different biological processes, and how the type of dataset impacts inferences…
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Artikel Jurnal Teks lengkap
Degradation of phenol via ortho-pathway by Kocuria sp . strain TIBETAN4 isolated from the soils around Qinghai Lake in China
Based on the feature of high-altitude permafrost topography and the diverse microbial ecological communities of the Qinghai-Tibetan Plateau, soil samples from thirteen different collection points around Qinghai lake were collected to screen for extremophilic strains with the ability to degrade…
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Artikel Jurnal Teks lengkap
Distribution of geographical scale, data aggregation unit and period in the correlation analysis between temperature and incidence of HFRS in mainland China: A systematic review of 27 ecological studies
Background: Changes in climate and environmental conditions could be the driving factors for the transmission of hantavirus. Thus, a thorough collection and analysis of data related to the epidemic status of hemorrhagic fever with renal syndrome (HFRS) and the association between HFRS incidence and…
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Artikel Jurnal Teks lengkap
Predicting the comprehensive geospatial pattern of two ephedrine-type alkaloids for Ephedra sinica in Inner Mongolia
Ephedra sinica Stapf. is a shrubby plant widely used in traditional Chinese medicine due to its high level of medicinal value, thus, it is in high demand. Ephedrine (E) and pseudoephedrine (PE) are key medicinal components and quality indicators for E. sinica. These two ephedrine-type alkaloids are…
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Artikel Jurnal Teks lengkap
EP300 promotes bladder cancer cell migration through SNAI2
EP300, a frequently mutated transcriptional coactivator in bladder cancer, has been demonstrated to positively correlate with malignancy in various cancers. Highly aggressive bladder cancers are often associated with muscle-invasive progression, a process closely linked to the…
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Artikel Jurnal Teks lengkap
Protective Effects of Polydatin from Polygonum cuspidatum against Carbon Tetrachloride-Induced Liver Injury in Mice
Polydatin is one of main compounds in Polygonum cuspidatum, a plant with both medicinal and nutritional value. The possible hepatoprotective effects of polydatin on acute liver injury mice induced by carbon tetrachloride (CCl4) and the mechanisms involved were investigated. Intraperitoneal…
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Artikel Jurnal Teks lengkap
Viral infection detection using metagenomics technology in six poultry farms of eastern China
With rapidly increasing animal pathogen surveillance requirements, new technologies are needed for a comprehensive understanding of the roles of pathogens in the occurrence and development of animal diseases. We applied metagenomic technology to avian virus surveillance to study the main viruses…
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Artikel Jurnal Teks lengkap
Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection
The Ebola virus (EBOV) has emerged as a significant global health concern, notably during the 2013–2016 outbreak in West Africa. Despite the clinical approval of two EBOV antibody drugs, there is an urgent need for more diverse and effective antiviral drugs, along with comprehensive understanding…
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Artikel Jurnal Teks lengkap
Autologous peroneus longus tendon graft for superior fulcrum reconstruction: Maintained prospective 1-year outcomes at short-term final follow-up
Background: Massive irreparable rotator cuff tears (MIRCTs) present challenges in terms of traditional treatments and can result in pain and functional impairment. Due to the limitations of traditional treatments for MIRCTs, alternative options such as superior fulcrum reconstruction (SFR) using…
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Artikel Jurnal Teks lengkap
From data to diagnosis: An innovative approach to epilepsy prediction with CGTNet incorporating spatio-temporal features
Epilepsy affects around 50 million people globally, causing significant burdens. While many methods predict seizures, current models struggle with handling spatiotemporal features and balancing accuracy with computational efficiency.This paper introduces a novel deep learning architecture called…
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Artikel Jurnal Teks lengkap
Single-cell RNA-seq landscape midbrain cell responses to red spotted grouper nervous necrosis virus infection
Viral nervous necrosis (VNN) is an acute and serious fish disease caused by nervous necrosis virus (NNV) which has been reported massive mortality in more than fifty teleost species worldwide. VNN causes damage of necrosis and vacuolation to central nervous system (CNS) cells in fish. It is…
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Artikel Jurnal Teks lengkap
Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture
Single-cell (SC) sequencing enables detailed characterization of transcriptional heterogeneity but lacks spatial context, while spatial transcriptomics (ST) preserves tissue organization yet is limited by resolution and incomplete gene capture. To bridge these gaps, we developed Cell2Spatial, a…
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Artikel Jurnal Teks lengkap
Forensic DNA Barcoding and Bio-Response Studies of Animal Horn Products Used in Traditional Medicine
Background: Animal horns (AHs) have been applied to traditional medicine for more than thousands of years, of which clinical effects have been confirmed by the history. But now parts of AHs have been listed in the items of wildlife conservation, which limits the use for traditional medicine. The…