4 hasil untuk "Ching-Lin Hsieh"
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Artikel Jurnal Teks lengkap
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure…
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Artikel Jurnal
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is metastable and difficult to produce recombinantly. We characterized 100 structure-guided spike designs and…
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Artikel Jurnal Teks lengkap
Broad neutralization of SARS-related viruses by human monoclonal antibodies
Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of a convalescent severe acute respiratory syndrome (SARS) donor and identified…
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Artikel Jurnal Teks lengkap
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates
, consistent with a typical human therapeutic antibody. In a rhesus macaque challenge model, prophylactic doses as low as 2.5 mg/kg reduced viral replication in the upper and lower respiratory tract in samples collected through study day 6 after viral inoculation. This antibody has entered clinical…