4 results for "David C. Lin"

Comparison between the kinematics for kangaroo rat hopping on a solid versus sand surface

Joseph K. Hall; Craig P. McGowan; David C. Lin

Royal Society Open Science, Vol. 9 No. 2 · 2022 · English · DOAJ Scopus

In their natural habitats, animals move on a variety of substrates, ranging from solid surfaces to those that yield and flow (e.g. sand). These substrates impose different mechanical demands on the musculoskeletal system and may therefore elicit different locomotion patterns. The goal of this study…

Trendelenburg-Like Gait, Instability and Altered Step Patterns in a Mouse Model for Limb Girdle Muscular Dystrophy 2i.

Joseph W Maricelli; Qi L Lu; David C Lin et al.

PLoS ONE, Vol. 11 No. 9 · 2016 · English · DOAJ Scopus

Limb-girdle muscular dystrophy type 2i (LGMD2i) affects thousands of lives with shortened life expectancy mainly due to cardiac and respiratory problems and difficulty with ambulation significantly compromising quality of life. Limited studies have noted impaired gait in patients and animal models…

Also available at: PLOS

Efficacy and muscle safety assessment of fukutin-related protein gene therapy

Halli Benasutti; Joseph W. Maricelli; Jane Seto et al.

Molecular Therapy: Methods & Clinical Development, Vol. 30 · 2023 · English · DOAJ

Limb-girdle muscular dystrophy type R9 (LGMDR9) is a muscle-wasting disease that begins in the hip and shoulder regions of the body. This disease is caused by mutations in fukutin-related protein (FKRP), a glycosyltransferase critical for maintaining muscle cell integrity. Here we investigated…