12 hasil untuk "Dharmendra Kumar"

Multifaceted bioactivity of brown seaweed-derived fucoidan from the Indian Coastline: A natural health product candidate

Manisha Prajapati; Dharmendra Kumar; Shivankar Agrawal dkk.

PLOS One, Vol. 21 No. 4 · 2026 · Inggris · PLOS Scopus

Brown seaweeds are rich in bioactive constituents, among which fucoidan a sulphated polysaccharide is particularly noted for its broad-spectrum therapeutic properties. This study explores the multifaceted bioactivity of fucoidan extracted from six brown seaweed species (Sargassum wightii, Sargassum…

Genomic Mechanisms Accounting for the Adaptation to Parasitism in Nematode-Trapping Fungi

Tejashwari Meerupati; Karl-Magnus Andersson; Eva Friman dkk.

PLoS Genetics, Vol. 9 No. 11 · 2013 · Inggris · PLOS Scopus

Orbiliomycetes is one of the earliest diverging branches of the filamentous ascomycetes. The class contains nematode-trapping fungi that form unique infection structures, called traps, to capture and kill free-living nematodes. The traps have evolved differently along several lineages and include…

Differentiation of Induced Pluripotent Stem Cells to Lentoid Bodies Expressing a Lens Cell-Specific Fluorescent Reporter

Taruna Anand; Thirumala R. Talluri; Dharmendra Kumar dkk.

PLOS ONE, Vol. 11 No. 6 · 2016 · Inggris · PLOS Scopus

Curative approaches for eye cataracts and other eye abnormalities, such as myopia and hyperopia currently suffer from a lack of appropriate models. Here, we present a new approach for in vitro growth of lentoid bodies from induced pluripotent stem (iPS) cells as a tool for ophthalmological…

Investigating host-virus interaction mechanism and phylogenetic analysis of viral proteins involved in the pathogenesis

Ahmad Abu Turab Naqvi; Farah Anjum; Alaa Shafie dkk.

PLOS ONE, Vol. 16 No. 12 · 2021 · Inggris · PLOS Scopus

Since the emergence of yellow fever in the Americas and the devastating 1918 influenza pandemic, biologists and clinicians have been drawn to human infecting viruses to understand their mechanisms of infection better and develop effective therapeutics against them. However, the complex molecular…

Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach

Alaa Shafie; Shama Khan; Sagar Batra dkk.

PLOS ONE, Vol. 16 No. 10 · 2021 · Inggris · PLOS Scopus

PIM1, is a serine/threonine proto-oncogene kinase, involved in many biological functions, including cell survival, proliferation, and differentiation, thus play a key role in oncogenesis. It plays a crucial role in the onset and progression of various hematopoietic and non-hematopoietic…

The Metabolic Score for Visceral Fat (METS-VF) as a predictor of diabetes mellitus: Evidence from the 2011–2018 NHANES study

Harshita Tripathi; Amandeep Singh; Farheen dkk.

PLOS ONE, Vol. 20 No. 2 · 2025 · Inggris · PLOS Scopus

Introduction: With 42.4% of obese US population, the prevalence of diabetes mellitus (DM) is increasing. Visceral fat, even at the same body mass index, has significant deleterious effects. This study aims to investigate the association between the Metabolic Score for Visceral Fat (METS-VF) and DM…

Effect of pH on the structure and function of cyclin-dependent kinase 6

Mohd Yousuf; Anas Shamsi; Farah Anjum dkk.

PLOS ONE, Vol. 17 No. 2 · 2022 · Inggris · PLOS Scopus

Cyclin-dependent kinase 6 (CDK6) is an important protein kinase that regulates cell growth, development, cell metabolism, inflammation, and apoptosis. Its overexpression is associated with reprogramming glucose metabolism through alternative pathways and apoptosis, which ultimately plays a…

Comparative analysis of web-based programs for single amino acid substitutions in proteins

Arunabh Choudhury; Taj Mohammad; Farah Anjum dkk.

PLOS ONE, Vol. 17 No. 5 · 2022 · Inggris · PLOS Scopus

Single amino-acid substitution in a protein affects its structure and function. These changes are the primary reasons for the advent of many complex diseases. Analyzing single point mutations in a protein is crucial to see their impact and to understand the disease mechanism. This has given many…

Semen parameters and fertility potency of a cloned water buffalo ( Bubalus bubalis ) bull produced from a semen-derived epithelial cell

Monika Saini; Suman Sheoran; Kennady Vijayalakshmy dkk.

PLOS ONE, Vol. 15 No. 8 · 2020 · Inggris · PLOS Scopus

Semen contains epithelial cells that can be cultured in vitro. For somatic cell nuclear transfer applications, it is essential to know whether clone(s) produced from semen-derived epithelial cells (SedECs) are healthy and reproductively competent. In this study, the semen and fertility profile of a…

Exploring the role of epidermal growth factor receptor variant III in meningeal tumors

Rashmi Rana; Vaishnavi Rathi; Kirti Chauhan dkk.

PLOS ONE, Vol. 16 No. 9 · 2021 · Inggris · PLOS Scopus

Meningioma is the second most common type of intracranial brain tumor. Immunohistochemical techniques have shown prodigious results in the role of epidermal growth factor receptor variant III (EGFR vIII) in glioma and other cancers. However, the role of EGFR vIII in meningioma is still in question…

Correction: Exploring the role of epidermal growth factor receptor variant III in meningeal tumors

Rashmi Rana; Vaishnavi Rathi; Kirti Chauhan dkk.

PLOS ONE, Vol. 20 No. 4 · 2025 · Inggris · PLOS Scopus

Livestock and rodents within an endemic focus of Visceral Leishmaniasis are not reservoir hosts for Leishmania donovani

Anurag Kumar Kushwaha; Ashish Shukla; Breanna M. Scorza dkk.

PLOS Neglected Tropical Diseases, Vol. 16 No. 10 · 2022 · Inggris · PLOS Scopus

Leishmaniasis on the Indian subcontinent is thought to have an anthroponotic transmission cycle. There is no direct evidence that a mammalian host other than humans can be infected with Leishmania donovani and transmit infection to the sand fly vector. The aim of the present study was to evaluate…