241 hasil untuk "Divya"
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Artikel Jurnal Teks lengkap
An integrative approach identifies direct targets of the late viral transcription complex and an expanded promoter recognition motif in Kaposi’s sarcoma-associated herpesvirus
The structural proteins of DNA viruses are generally encoded by late genes, whose expression relies on recruitment of the host transcriptional machinery only after the onset of viral genome replication. β and γ-herpesviruses encode a unique six-member viral pre-initiation complex (vPIC) for this…
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A hybrid CNN-XLSTM-GRU deep learning model with autoencoder-based feature selection for hypothyroidism diagnosis
Hypothyroidism, caused by reduced thyroid-hormone production, is often difficult to diagnose because its symptoms are non-specific and overlap with other disorders. We developed FusionNet-CXG, a hybrid deep-learning model that couples CNN, eXtended LSTM, and GRU components for hypothyroidism…
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Supervised machine learning-based prediction of modern contraceptive use among sexually active women in Nepal
Modern contraceptives play a key role in reducing maternal and infant mortality, preventing unsafe abortions, and advancing women’s social and economic participation. Despite their importance, contraceptive use remains uneven across subpopulations in Nepal. This study aimed to identify key…
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The C-Terminus of ClpC1 of Mycobacterium tuberculosis Is Crucial for Its Oligomerization and Function
Mycobacterium tuberculosis ClpC1 is a member of the Hsp100/Clp AAA+ family of ATPases. The primary sequence of ClpC1 contains two N-terminal domains and two nucleotide binding domains (NBD). The second NBD has a long C-terminal sub-domain containing several motifs important for substrate…
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Rab11 Plays an Indispensable Role in the Differentiation and Development of the Indirect Flight Muscles in Drosophila
Rab11, an evolutionary conserved, ubiquitously expressed subfamily of small monomeric GTPase has been known to regulate diverse cellular and developmental events, by regulating the exocytotic and transcytotic events inside the cell. Our studies show that Rab11 regulates Drosophila adult myogenesis…
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Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA
In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed. Slowing of replication allows for tolerance of DNA damage and suppresses genomic…
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Stepping forward: A study protocol for developing and validating a Malaysian diabetic foot self-care practice assessment instrument
Introduction: Diabetic foot ulcers impose significant financial burdens and diminished quality of life. Effective management relies on patients’ self-care, yet often overlooked by patients as neuropathic feet are painless. In Malaysia, primary care facilities focus on prevention by promoting proper…
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A Gender-Based Analysis of High School Athletes Using Computerized Electrocardiogram Measurements
Background: The addition of the ECG to the preparticipation examination (PPE) of high school athletes has been a topic for debate. Defining the difference between the high school male and female ECG is crucial to help initiate its implementation in the High School PPE. Establishing the different…
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Measuring Unsafe Abortion-Related Mortality: A Systematic Review of the Existing Methods
Background: The WHO estimates that 13% of maternal mortality is due to unsafe abortion, but challenges with measurement and data quality persist. To our knowledge, no systematic assessment of the validity of studies reporting estimates of abortion-related mortality exists. Study Design: To be…
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Localization of Low Copy Number Plasmid pRC4 in Replicating Rod and Non-Replicating Cocci Cells of Rhodococcus erythropolis PR4
Rhodococcus are gram-positive bacteria, which can exist in two different shapes rod and cocci. A number of studies have been done in the past on replication and stability of small plasmids in this bacterium; however, there are no reports on spatial localization and segregation of these plasmids. In…
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Bring dying at home: What facilitates and hinders home-based end-of-life care for people living with dementia?—A systematic review and meta-ethnography protocol
Background: Although home-based end-of-life care is more in line with the preferences of people living with dementia, operationalizing this ideal remains challenging. Many people living with dementia are still unable to die at home or receive end-of-life care at home. This review aims to apply…
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LIN-44/Wnt Directs Dendrite Outgrowth through LIN-17/Frizzled in C. elegans Neurons
Nervous system function requires proper development of two functional and morphological domains of neurons, axons and dendrites. Although both these domains are equally important for signal transmission, our understanding of dendrite development remains relatively poor. Here, we show that in C…
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“I Feel Contaminated in My Fake Hand”: Obsessive-Compulsive-Disorder like Disgust Sensations Arise from Dummy during Rubber Hand Illusion
Despite its theoretical and clinical interest, there are no experimental studies exploring obsessive-compulsive disorder (OCD)-like disgust sensations through using somatosensory illusions. Such illusions provide important clues to the nature and limits of multisensory integration and how the brain…
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Comparing subsampling strategies for metagenomic analysis in microbial studies using amplicon sequence variants versus operational taxonomic units
The microbiome is increasingly regarded as a key component of human health, and analysis of microbiome data can aid in the development of precision medicine. Due to the high cost of shotgun metagenomic sequencing (SM-seq), microbiome analyses can be done cost-effectively in two phases: Phase…
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Comparing the effectiveness of mother-focused interventions to that of mother-child focused interventions in improving maternal postpartum depression outcomes: A systematic review
Background: Most empirically researched interventions for postpartum depression (PPD) tend to target mothers’ depression alone. Harmful effects of PPD on physical and mental health of both mother and child has led researchers to investigate the impact of interventions on PPD and child outcomes…
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Knowledge and practices about vocal hygiene among speech-language pathologists in India
Background: The objective of the present study was to explore the knowledge and practices about vocal hygiene among speech language pathologists in India. Methods: An online survey was conducted to explore the knowledge and practices about vocal hygiene among speech language pathologists in India…
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Double Deception: Ant-Mimicking Spiders Elude Both Visually- and Chemically-Oriented Predators
Biological mimicry is often multimodal, in that a mimic reinforces its resemblance to another organism via different kinds of signals that can be perceived by a specific target audience. In this paper we describe a novel scenario, in which a mimic deceives at least two distinct audiences, each of…
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Ecosystem approach to fisheries: Exploring environmental and trophic effects on Maximum Sustainable Yield (MSY) reference point estimates
We present a comprehensive analysis of estimation of fisheries Maximum Sustainable Yield (MSY) reference points using an ecosystem model built for Mille Lacs Lake, the second largest lake within Minnesota, USA. Data from single-species modelling output, extensive annual sampling for species…
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DiffSLC: A graph centrality method to detect essential proteins of a protein-protein interaction network
Identification of central genes and proteins in biomolecular networks provides credible candidates for pathway analysis, functional analysis, and essentiality prediction. The DiffSLC centrality measure predicts central and essential genes and proteins using a protein-protein interaction network…
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Autonomous Vehicles: Disengagements, Accidents and Reaction Times
Autonomous vehicles are being viewed with scepticism in their ability to improve safety and the driving experience. A critical issue with automated driving at this stage of its development is that it is not yet reliable and safe. When automated driving fails, or is limited, the autonomous mode…