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Covalent inhibitors: a rational approach to drug discovery

Fandi Sutanto; Markella Konstantinidou; Alexander S. S. Dömling

RSC Medicinal Chemistry · 2020 · Inggris · OpenAlex Scopus

Covalent inhibitors are recognized as an important component in drug discovery and therapeutics. Since the first appearance of covalent inhibitors in the late 18th century, the field has advanced significantly and currently about 30% of the marketed drugs are covalent inhibitors. The numerous…