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RSC Medicinal Chemistry
Scopus
ISSN 2632-8682 · Royal Society of Chemistry · 4 artikel di indeks
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Artikel Jurnal
Put a ring on it: application of small aliphatic rings in medicinal chemistry
Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry for their beneficial physicochemical properties and applications as functional group bioisosteres. This review…
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Artikel Jurnal
β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates
Overview of β-lactam antibiotics and the proteins with which they covalently interact, focusing on penicillin-binding proteins and serine β-lactamases.
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Artikel Jurnal
Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis
Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these moieties constitute a common framework of a variety of drugs and bioactive compounds endowed with a broad range of therapeutic and pharmacological properties. Herein, we provide an overview of the…
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Artikel Jurnal Teks lengkap
Covalent inhibitors: a rational approach to drug discovery
Covalent inhibitors are recognized as an important component in drug discovery and therapeutics. Since the first appearance of covalent inhibitors in the late 18th century, the field has advanced significantly and currently about 30% of the marketed drugs are covalent inhibitors. The numerous…