7 hasil untuk "Gen-Lin He"

Curcumin Ameliorates the Reduction Effect of PGE 2 on Fibrillar β-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells

Gen-Lin He; Zhen Luo; Ju Yang dkk.

PLOS ONE, Vol. 11 No. 1 · 2016 · Inggris · PLOS Scopus

Inflammatory activation of microglia and β amyloid (Aβ) deposition are considered to work both independently and synergistically to contribute to the increased risk of Alzheimer’s disease (AD). Recent studies indicate that long-term use of phenolic compounds provides protection against AD…

Juga tersedia di: DOAJ

TREM2 Regulates Heat Acclimation-Induced Microglial M2 Polarization Involving the PI3K-Akt Pathway Following EMF Exposure

Gen-Lin He; Zhen Luo; Ting-Ting Shen dkk.

Frontiers in Cellular Neuroscience, Vol. 13 · 2020 · Inggris · DOAJ Scopus

The function of triggering receptor expressed on myeloid cells-2 (TREM2) has been described within microglia with a beneficial activated phenotype. However, the role of TREM2 underlying microglial phenotypic alterations in the cross-tolerance protection of heat acclimation (HA) against the…

MicroRNA-155 Promotes Heat Stress-Induced Inflammation via Targeting Liver X Receptor α in Microglia

Ping Li; Gong Wang; Xiao-Liang Zhang dkk.

Frontiers in Cellular Neuroscience, Vol. 13 · 2019 · Inggris · DOAJ Scopus

Background: The neuroinflammatory responses of microglial cells play an important role in the process of brain dysfunction caused by heat stroke. MicroRNAs are reportedly involved in a complex signaling network and have been identified as neuroinflammatory regulators. In this study, we determined…

Increased miR-155 in Microglial Exosomes Following Heat Stress Accelerates Neuronal Autophagy via Their Transfer Into Neurons

Ping Li; Xue Luo; Zhen Luo dkk.

Frontiers in Cellular Neuroscience, Vol. 16 · 2022 · Inggris · DOAJ Scopus

BackgroundHeat stroke is the outcome of excessive heat stress, which results in core temperatures exceeding 40°C accompanied by a series of complications. The brain is particularly vulnerable to damage from heat stress. In our previous studies, both activated microglia and increased neuronal…

Corrigendum to “L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats” [Heliyon Volume 10, Issue 22, November 2024, Article e40502]

Bo-Yi Zhang; Gen-Lin He; Ze-Ze Wang dkk.

Heliyon, Vol. 11 No. 16 · 2025 · Inggris · DOAJ Scopus

L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats

Bo-Yi Zhang; Gen-Lin He; Ze-Ze Wang dkk.

Heliyon, Vol. 10 No. 22 · 2024 · Inggris · DOAJ Scopus

Exertional heatstroke (EHS) is a life-threatening condition with potential for tissues and organs injury, including heart. Effective drug strategies to treat patients with EHS are warranted to unlock the therapeutic potential. Considering the cardioprotective effects of L-carnitine (LC), this study…