46 hasil untuk "Girard, Pascal"
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Artikel Jurnal Teks lengkap
Historical Use of Markov Model and Posterior Predictive Checks in Pharmacometrics
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Preprint Teks lengkap
Abundances and ages of the deconvolved thin/thick disks of the Galaxy
We have investigated the abundance of several chemical elements in two large stellar samples kinematically representative of the thin and the thick disks of the Galaxy. Chemical, kinematical and age data have been collected from high quality sources in the literature. Velocities (U,V,W) have been…
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Preprint Teks lengkap
[alpha/Fe] in the thin and the thick disk towards an automatic parametrization of stellar spectra
We test an automatic procedure to measure [Fe/H] and [alpha/Fe] on high resolution spectra. The test sample is the intersection of the ELODIE library and a catalogue of 830 stars having well determined abundances.
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Artikel Jurnal Teks lengkap
Ultra-Rapid Categorization of Fourier-Spectrum Equalized Natural Images: Macaques and Humans Perform Similarly
BACKGROUND: Comparative studies of cognitive processes find similarities between humans and apes but also monkeys. Even high-level processes, like the ability to categorize classes of object from any natural scene under ultra-rapid time constraints, seem to be present in rhesus macaque monkeys…
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Artikel Jurnal Teks lengkap
Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called “episodic-like memory”, several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science…
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Artikel Jurnal Teks lengkap
Coding of shape from shading in area V4 of the macaque monkey
Abstract Background The shading of an object provides an important cue for recognition, especially for determining its 3D shape. However, neuronal mechanisms that allow the recovery of 3D shape from shading are poorly understood. The aim of our study was to determine the neuronal basis of 3D shape…
Juga tersedia di: PubMed Central
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Artikel Jurnal Teks lengkap
Population pharmacokinetic and pharmacodynamic modeling of evobrutinib in healthy adult participants
Evobrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, has shown therapeutic potential in relapsing multiple sclerosis. This analysis aimed to develop pharmacokinetic (PK) and pharmacodynamic (PD; BTK occupancy [BTKO]) models of evobrutinib and simulate PK and BTKO profiles under alternative…
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Artikel Jurnal Teks lengkap
Comparison of Various Phase I Combination Therapy Designs in Oncology for Evaluation of Early Tumor Shrinkage Using Simulations
There is still a lack of efficient designs for identifying the dose response in oncology combination therapies in early clinical trials. The concentration response relationship can be identified using the early tumor shrinkage time course, which has been shown to be a good early response marker of…
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Artikel Jurnal Teks lengkap
Assessing Similarity Among Individual Tumor Size Lesion Dynamics: The CICIL Methodology
Mathematical models of tumor dynamics generally omit information on individual target lesions (iTLs), and consider the most important variable to be the sum of tumor sizes (TS). However, differences in lesion dynamics might be predictive of tumor progression. To exploit this information, we have…
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Artikel Jurnal Teks lengkap
Determination of a clinically effective evobrutinib dose: Exposure–response analyses of a phase II relapsing multiple sclerosis study
The pharmacometric analysis of the double‐blind, randomized, phase II study (NCT02975349) investigating the safety and efficacy of evobrutinib, explored exposure–response relationships and suitable dosing regimens of evobrutinib for relapsing multiple sclerosis. Population pharmacokinetic…
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Artikel Jurnal Teks lengkap
Population pharmacokinetic analysis of tepotinib, an oral MET kinase inhibitor, including data from the VISION study
PURPOSE: Tepotinib is a highly selective, potent, mesenchymal–epithelial transition factor (MET) inhibitor, approved for the treatment of non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping. Objectives of this population pharmacokinetic (PK) analysis were to evaluate the dose–exposure…
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Artikel Jurnal Teks lengkap
Population pharmacokinetic model selection assisted by machine learning
A fit-for-purpose structural and statistical model is the first major requirement in population pharmacometric model development. In this manuscript we discuss how this complex and computationally intensive task could benefit from supervised machine learning algorithms. We compared the classical…
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Artikel Jurnal Teks lengkap
Fast screening of covariates in population models empowered by machine learning
One of the objectives of Pharmacometry (PMX) population modeling is the identification of significant and clinically relevant relationships between parameters and covariates. Here, we demonstrate how this complex selection task could benefit from supervised learning algorithms using importance…
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Artikel Jurnal Teks lengkap
Model-based design of rituximab dosage optimization in follicular non-Hodgkin's lymphoma
AIMS: Rituximab has dramatically improved the survival of patients with non-Hodgkin's lymphoma (NHL). However, studies have suggested that the dose regimen currently used (i.e. 375 mg m(−2)) could be optimized. The aims of this study were to quantify the benefits of the new dose regimen for…
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Artikel Jurnal Teks lengkap
Development of a drug–disease simulation model for rituximab in follicular non-Hodgkin's lymphoma
AIM: Rituximab has dramatically improved the survival of patients with non-Hodgkin's lymphomas (NHL), but the dosing regimen currently used should be optimized. However, the concentration–effect relationship of rituximab has never been described by pharmacokinetic–pharmacodynamic (PK–PD) modelling…
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Artikel Jurnal Teks lengkap
Multisensory integration in neurons of the medial pulvinar of macaque monkey
The pulvinar is a heterogeneous thalamic nucleus, which is well developed in primates. One of its subdivisions, the medial pulvinar, is connected to many cortical areas, including the visual, auditory, and somatosensory cortices, as well as with multisensory areas and premotor areas. However…
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Artikel Jurnal Teks lengkap
Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study
This study aimed to explore the currently competing and new semimechanistic clearance models for monoclonal antibodies and the impact of clearance model misspecification on exposure metrics under different study designs exemplified for cetuximab. Six clearance models were investigated under four…
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Artikel Jurnal Teks lengkap
Population pharmacokinetics of atacicept in systemic lupus erythematosus: An analysis of three clinical trials
B cell stimulating factor (BLyS) and a proliferation‐inducing ligand (APRIL) are targets for novel treatments in patients with systemic lupus erythematosus (SLE). Atacicept is a recombinant, soluble fusion protein that blocks BLyS and APRIL activity. This study characterized the pharmacokinetic…
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Artikel Jurnal Teks lengkap
The variability of multisensory processes of natural stimuli in human and non-human primates in a detection task
BACKGROUND: Behavioral studies in both human and animals generally converge to the dogma that multisensory integration improves reaction times (RTs) in comparison to unimodal stimulation. These multisensory effects depend on diverse conditions among which the most studied were the spatial and…