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BMC Neuroscience
Scopus
ISSN 1471-2202 · BMC · 3.133 artikel di indeks
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Artikel Jurnal
Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain
Abstract Background The glycinergic system constitutes a main source of inhibitory regulation in the central nervous system. Glycine transporters (GLYT1 and GLYT2), encoded by Slc6a9 and Slc6a5, respectively, are responsible for glycine reuptake and clearance from the synaptic cleft, thereby…
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Artikel Jurnal
MEF2A-mediated inhibition of ischemic stroke injury via the PI3K/AKT pathway: a comprehensive bioinformatics and in vitro study
Abstract Background Thrombosis or embolism causes blood flow stoppage, resulting in ischemic stroke (IS), the most frequent clinical cerebrovascular disorder. It accounts for more than 80% of all strokes and has a significant disability and mortality rate. Regulating critical targets to stop the…
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Artikel Jurnal
Oxidative and histopathological changes in the hippocampus and prefrontal cortex following light-at-night and methamphetamine exposure
Abstract Background Methamphetamine (METH) is a potent psychostimulant with neurotoxic effects, while exposure to light-at-night (LAN) disrupts circadian rhythms and contributes to neuronal stress. Both are independently associated with oxidative damage and cognitive impairment, yet their combined…
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Artikel Jurnal
Precise Aβ clearance and antioxidant therapy in Alzheimer’s disease via photoacoustic imaging-guided palladium hydride nanosheet-mediated photothermal treatment
Abstract Inflammation and oxidative stress are critical pathological hallmarks of Alzheimer’s disease (AD). Hydrogen therapy shows promise due to its selective hydroxyl radical (∙OH) scavenging capacity, yet conventional hydrogen delivery fails to effectively accumulate in the brain due to low…
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Artikel Jurnal
Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis and oxidative stress in an in vitro Parkinson’s disease model
Abstract Folate receptors, which mediate the cellular uptake of folic acid (FA) for essential processes such as DNA synthesis and repair, are expressed on neurons affected in Parkinson’s disease (PD). While the etiology of PD remains incompletely understood, oxidative stress is implicated as a key…
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Artikel Jurnal
Exploring extracellular vesicle surface markers and microRNA regulation following remote ischemic conditioning in patients with stroke; a randomized-controlled pilot study
Abstract Remote ischemic conditioning (RIC) has demonstrated neuroprotective effects, yet translating these effects into clinical efficacy has proven challenging. This study aims to uncover the molecular mechanisms underlying RIC’s protective effects, which could potentially identify new…
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Artikel Jurnal
Modulation of stress and neuroplasticity biomarkers via rhythmic vocalization: a controlled study on NDNF, cortisol, and monoamines
Abstract Background The aim of this study is to investigate the effect of reciting the Quran (from Mushaf) on serotonin, dopamine, NDNF, and cortisol levels in relation to mental well-being. Methods This study was conducted on a sample of university students who know how to read the Quran in…
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Artikel Jurnal
Neuroprotective effects of sulfasalazine in experimental model of seizures and epilepsy
Abstract Overexpression of Sxc-, a cystine/glutamate antiporter is implicated in several neurological disorders including epilepsy. Physiologically, it regulates the hippocampal synaptic glutamate pool, influencing the neuronal excitability. Sulfasalazine (SAS) recently garnered interest owing to…
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Artikel Jurnal
Investigating effects of day-to-day variations in environmental exposure on the human brain: study protocol for the Day2Day Environment project
Abstract Background Understanding how daily environmental exposures influence the human brain and mental health is increasingly important in the context of global urbanization and climate change. Previous studies have focused primarily on long-term environmental factors or isolated features like…
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Artikel Jurnal
Iron overload induces ROS-mediated neural stem/progenitor cells apoptosis via mTOR pathway
Abstract Intracerebral hemorrhage (ICH) is a health challenge resulting in death or disability. Iron overload has been identified as one of post-ICH damaging factors. However, the impact of iron overload, as well as the underlying mechanisms, on neural stem/progenitor cells (NSPCs) remains unknown…
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Artikel Jurnal
Ibogaine induces juvenile-like plasticity and modulates functional and structural regulators of plasticity in the adult mouse visual cortex
Abstract Background Psychedelics have emerged as powerful modulators of neural plasticity, yet whether the atypical psychedelic ibogaine can enhance plasticity remains poorly understood. Here, we investigated whether a single administration of ibogaine can reinstate juvenile-like…
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Artikel Jurnal
Combined maternal separation and limited bedding-nesting increase goal tracking, delay discounting, and impulsive action, and moderate sign-tracking-perseverance associations in male rats
Abstract Background Extensive research with rodent models has shown detrimental effects of early-life adversity (ELA) on behavioral (e.g., impulsive behavior, anxiety, and depression) and neurobiological processes (e.g., alterations of neuroendocrine processes and maturation of brain areas)…
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Artikel Jurnal
Glycine as a potential neuroprotective adjuvant to reduce cisplatin-induced brain inflammation in mice
Abstract Background Cisplatin-induced neurotoxicity is driven in part by neuroinflammation and oxidative injury in vulnerable brain regions. Glycine has anti-inflammatory and antioxidant properties that may offer neuroprotection against chemotherapy-related brain damage. Methods Twenty-five adult…
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Artikel Jurnal
Structural characteristics of local cortical networks wired by distance dependent connectivity rules
Abstract Background The function of the cerebral cortex is shaped by its anatomical connectivity, yet experimental findings on connection probabilities in local cortical networks remain inconsistent. This study explores structural characteristics of local cortical networks based on distance…
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Artikel Jurnal
Taurine reverses long-term memory deficits caused by LPS induced neuroinflammation
Abstract Background Despite neuroinflammation being an initially protective response made by the central nervous system (CNS), as it becomes chronic, it can lead to neuronal damage since the cytokines which are released by microglia potentialize cellular death due to excitotoxicity, and this, in…
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Artikel Jurnal
Proteomic profiling reveals structural and adhesion pathways regulated by the inverted CHRFAM7AΔ2bp variant in human neural progenitor cells
Abstract The CHRNA7 gene, located on chromosome 15q13.3, encodes the α7 nicotinic acetylcholine receptor (α7 nAChR) subunit and lies within a genomic region characterized by high recombination rates and associations with multiple neuropsychiatric disorders. Within this region, the human specific…
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Artikel Jurnal
Clofazimine against cerebral toxoplasmosis in diabetic and dexamethasone-immunosuppressed mice: ultrastructural and semiquantitative transmission electron microscopic study
Abstract Cerebral toxoplasmosis is a common opportunistic parasitic infection of the CNS caused by the Toxoplasma gondii parasite. Host immunosuppression can affect disease outcomes. To explore the changes in the cerebral cortical ultrastructure accompanying the infection in different…
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Artikel Jurnal
Neural and emotional responses to mood induction and emotional design in multimedia learning
Abstract This study investigates the effect of external mood induction and emotional design on learning and cognitive and affective outcomes in multimedia learning environments. Eye tracking and neuroimaging (EEG) methods were utilized to examine cognitive processes more thoroughly. Two different…
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Artikel Jurnal
Using combined ROC curves to improve the diagnostic usefulness of glutaminase, prostaglandins, and 8-isoprostane as biomarkers of autism spectrum disorders;Role in the Glu-GABA-Gln cycle
Abstract Due to delayed symptoms and dependence of behavioral assessment, early diagnosis of autism spectrum disorder remains challenging. Identification of multivariate biomarker for the etiological mechanisms of ASD may enhance diagnostic accuracy. Multivariable logistic regression combines many…
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Artikel Jurnal
Neurobehavioral deficits, oxidative dysregulation, and inflammatory responses in male Swiss mice following sub-acute exposure to ethanol extract of Leiotrametes lactinea Berk
Abstract Background Leiotrametes lactinea (Berk.) Welti & Courtec. a mushroom reported to possess antimicrobial, antioxidant, antitumor and analgesic activities. However, there is limited information on its safety profile in the central nervous system. This study thus evaluates the neurotoxic…
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