23 hasil untuk "Gui-Rong Li"
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Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals
The strategy of decreasing atherosclerotic cardiovascular disorder is imperative for reducing premature death and improving quality of life in patients with diabetes mellitus. The aim of this study was to investigate whether the natural flavone acacetin could protect against endothelial injury…
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Cholesterol Down-Regulates BK Channels Stably Expressed in HEK 293 Cells
Cholesterol is one of the major lipid components of the plasma membrane in mammalian cells and is involved in the regulation of a number of ion channels. The present study investigates how large conductance Ca2+-activated K+ (BK) channels are regulated by membrane cholesterol in BK-HEK 293 cells…
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The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells
The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models. The present study investigates whether acacetin inhibits the Ca2+-activated potassium (KCa) currents, including small…
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Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels
The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (Ito) in human atrial myocytes. However, the molecular determinants of acacetin for blocking Ito are unknown. The present study was designed to investigate the properties and molecular determinants of…
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Correction: Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels
[This corrects the article DOI: 10.1371/journal.pone.0057864.].
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Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts
Background: Although fibroblast-to-myocyte electrical coupling is experimentally suggested, electrophysiology of cardiac fibroblasts is not as well established as contractile cardiac myocytes. The present study was therefore designed to characterize ion channels in cultured human cardiac…
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Effects of BK Ca and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit + Progenitor Cells
Our previous study demonstrated that a large-conductance Ca2+-activated K+ current (BKCa), a voltage-gated TTX-sensitive sodium current (INa.TTX), and an inward rectifier K+ current (IKir) were heterogeneously present in most of human cardiac c-kit+ progenitor cells. The present study was designed…
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Influence of a high pulsed magnetic field on the tensile properties and phase transition of 7055 aluminum alloy
The effect of a high pulsed magnetic field on the tensile properties and microstructure of 7055 alloy were investigated. In the tensile properties test, the pulsed magnetic field was applied to improve the tensile strength and elongation via the magnetoplasticity effect. The results show that when…
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Albiflorin: a promising natural monoterpene glycoside with potential therapeutic benefits for multiple physiological systems
Plants of genus Paeonia have both medicinal and edible value for a long history. Albiflorin (AF), one of the characteristic monoterpenoid glycosides of Paeonia L. plants, has extensive protective effects in nervous system, cardiovascular and cerebrovascular system, digestive system, endocrine…
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Acacetin Attenuates Lysophosphatidylcholine-Induced Vascular Smooth Muscle Cell Injury via Sirt1-Nrf2/p62 Signaling Axis
Background: Acacetin, a naturally occurring flavone present in various plants, is known as a promising drug candidate for cardiovascular disorders. Our previous study demonstrated that acacetin ameliorates atherosclerosis through endothelial cell protection; however, its pharmacological effects on…
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Acacetin alleviates autoimmune myocarditis by regulating CD4+ T cell mitochondrial respiration
Abstract Background Myocarditis refers to an autoimmune inflammatory response of the myocardium with characterization of self-reactive CD4+ T cell activation, which lacks effective treatment and has a poor prognosis. Acacetin is a natural flavonoid product that has been reported to have…
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Allitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells
Allitridi (diallyl trisulfide) is an active compound (volatile oil) from garlic. The previous studies reported that allitridi had anti-arrhythmic effect. The potential ionic mechanisms are, however, not understood. The present study was designed to determine the effects of allitridi on cardiac…
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Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes
Background: J wave syndromes (JWS), including Brugada (BrS) and early repolarization syndromes (ERS), are associated with increased risk for life-threatening ventricular arrhythmias. Pharmacologic approaches to therapy are currently very limited. Here, we evaluate the effects of the natural flavone…
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The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway
The present study investigates the potential signal pathway of acacetin in cardioprotection against ischemia/reperfusion injury using an in vitro hypoxia/reoxygenation model in primary cultured neonatal rat cardiomyocytes and H9C2 cardiomyoblasts. It was found that acacetin (0.3–3 μM) significantly…