1,095 results for "Guo, Lin"
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Protection and Inheritance of Traditional Culture in Urbanization Construction Based on Genetic Algorithm under the Concept of Environmental Protection
Chinese traditional culture is a typical “moral culture,” and traditional morality is the core and essence of culture. However, in recent years, the phenomenon of following the trend of rural construction has been particularly serious, and many villages have lost their original features. To solve…
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Short-term clinical outcomes associated with a standardized multicomponent facial rehabilitation program in acute or early-subacute peripheral facial nerve palsy: a prospective controlled cohort study
BackgroundPeripheral facial nerve palsy can impair facial symmetry, eye closure, oral competence, communication, and quality of life. Although spontaneous recovery is common, some patients experience persistent functional and psychosocial impairment. Evidence for structured adjunctive…
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Sparks of Artificial General Recommender (AGR): Experiments with ChatGPT
This study investigates the feasibility of developing an Artificial General Recommender (AGR), facilitated by recent advancements in Large Language Models (LLMs). An AGR comprises both conversationality and universality to engage in natural dialogues and generate recommendations across various…
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Precision treatment of the knee: evolution and prospects from structural repair to functional remodeling
Abstract Precision treatment of the knee is moving from structural repair toward deep integration of functional remodeling and individualized decision-making. In the field of sports medicine, anterior cruciate ligament reconstruction enables submillimeter-level positioning of bone tunnels based on…
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Simple Method to Enhance the Photostability of the Fluorescence Reporter R6G for Prolonged Single Molecule Studies
For fluorescence-based single-molecule studies, photobleaching of the dye reporter often limits the time window over which individual molecules can be followed. As such, many strategies, for example using a cocktail of chemical reagents, have been developed to decrease the rate of photobleaching…
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Immobilized transferrin Fe(3)O(4)@SiO(2) nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
Transferrin (Tf) was immobilized onto Fe(3)O(4)@SiO(2) nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high…
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Heterogeneous Diffusion of a Membrane-Bound pHLIP Peptide
Lateral diffusion of cell membrane constituents is a prerequisite for many biological functions. However, the diffusivity (or mobility) of a membrane-bound species can be influenced by many factors. To provide a better understanding of how the conformation and location of a membrane-bound…
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It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles
Paradigm-shifting advances have revealed that diverse membraneless organelles originate via liquid-liquid phase separation, but how their distinct structural and functional milieux are specified is not understood. Recent work elucidates that RNA governs the biophysical characteristics of liquid…
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Facet‐Controlled Synthetic Strategy of Cu(2)O‐Based Crystals for Catalysis and Sensing
Shape‐dependent catalysis and sensing behaviours are primarily focused on nanocrystals enclosed by low‐index facets, especially the three basic facets ({100}, {111}, and {110}). Several novel strategies have recently exploded by tailoring the original nanocrystals to greatly improve the catalysis…
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Nanocrystal Facets: Facet‐Controlled Synthetic Strategy of Cu(2)O‐Based Crystals for Catalysis and Sensing (Adv. Sci. 10/2015)
Several novel strategies have been developed by tailoring nanocrystals (NCs) to improve their catalysis and sensing performances. In article number 1500140, Y. Shang and L. Guo review in detail the three main Cu(2)O facet‐controlled synthetic strategies (deposition, etching and templating) for…
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Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies
Cytoplasmic TDP-43 mislocalization and aggregation is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is an RNA-binding protein (RBP) with a prion-like domain (PrLD) that promotes TDP-43 misfolding. PrLDs possess compositional similarity to…
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Oxymatrine Inhibits the Proliferation and Invasion of Breast Cancer Cells via the PI3K Pathway
PURPOSE: Oxymatrine has been reported to possess anti-cancer activity, but its role in breast cancer (BC) is weakly defined. We investigated the anti-cancer effects of oxymatrine in human BC cells, and the underlying molecular mechanisms of these effects. METHODS: BC lines were treated with…
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TP73-AS1 promotes gastric cancer proliferation and invasion by regulation miR-27b-3p/TMED5 axis
Background: Gastric cancer (GC) is a common gastrointestinal malignancy. Evidence suggests that long non-coding RNAs (lncRNAs) influence mRNA expression to induce GC progression. We aim to investigate the function and regulatory mechanism of TP73-AS1 in GC. Materials and methods: We detected…
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Karyopherin-βs play a key role as a phase separation regulator
Recent studies have revealed that cells utilize liquid–liquid phase separation (LLPS) as a mechanism in assembly of membrane-less organelles, such as RNP granules. The nucleus is a well-known membrane-bound organelle surrounded by the nuclear envelope; the nuclear pore complex on the nuclear…
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MicroRNA‐148a‐3p inhibits cancer progression and is a novel screening biomarker for gastric cancer
PURPOSE: Dysregulation of miR‐148a‐3p in gastric cancer was reported. However, the diagnostic potential and biological function of miR‐148a‐3p in gastric cancer progression is not fully studied. METHODS: Bioinformatics analysis and RT‐qPCR assay were performed to analyze the expression of…
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Digital transformation, green innovation and the Solow productivity paradox
To provide evidence at the micro level for cracking the Solow productivity paradox, this paper deeply studies the impact of enterprise digital transformation on green innovation. In terms of theoretical research, three potential mechanisms are excavated for the first time; considering empirical…
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Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors
SIMPLE SUMMARY: Aberrant protein phase transitions and aggregation trigger various neurodegenerative diseases, including ALS, FTD, Alzheimer’s disease, and Huntington’s disease. Dynamic exchange of proteins and RNA between the nucleus and cytoplasm is essential for cellular functioning, which is…
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Advancing gastric cancer treatment: nanotechnology innovations and future prospects
Gastric cancer (GC) is the fifth most common cancer worldwide, particularly prevalent in Asia, especially in China, where both its incidence and mortality rates are significantly high. Meanwhile, nanotechnology has demonstrated great potential in the treatment of GC. In particular, nanodrug…
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Recent advances in solid–liquid triboelectric nanogenerator technologies, affecting factors, and applications
Converting dispersed mechanical energy into electrical energy can effectively improve the global energy shortage problem. The dispersed mechanical energy generated by liquid flow has a good application prospect as one of the most widely used renewable energy sources. Solid–liquid triboelectric…
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YAP/TEAD-induced PRIM1 contributes to the progression and poor prognosis of gastric carcinoma
Gastric carcinoma has a poor prognosis and low survival rate. PRIM1 is closely associated with the origin of DNA replication and serves as a carcinogenic factor in multiple tumors. This study aimed to explore the functions of PRIM1 in the progression of gastric carcinoma. The luciferase reporter…
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