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Frontiers in Neurology
Scopus
ISSN 1664-2295 · Frontiers Media S.A. · 21,663 articles in the index
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Journal Article
Association of infarct volume with early neurological deterioration in ischemic stroke patients undergoing endovascular treatment
BackgroundEarly neurological deterioration (END) remains a frequent and serious complication after endovascular treatment (EVT) for ischemic stroke (IS), even in patients with successful recanalization. The role of infarct volume in predicting END, particularly in the EVT population, has not been…
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Journal Article
Analysis of discrepancies in hemorrhagic transformation and infarct volume in ischemic stroke patients undergoing endovascular treatment
ObjectiveAfter endovascular treatment (EVT) for ischemic stroke (IS), clinical observations have shown that some patients with small infarct volumes develop hemorrhagic transformation (HT), while some patients with large infarct volumes do not. This study aims to analyze the factors contributing to…
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Journal Article
Effects of general anesthesia on short-term outcomes of patients with acute ischemic stroke after endovascular treatments: a meta-analysis
The optimal anesthetic strategy for endovascular treatment (EVT) in acute ischemic stroke (AIS) remains uncertain. This meta-analysis of randomized controlled trials (RCTs) compared the effects of general anesthesia (GA) and non-general anesthesia (non-GA) on reperfusion success and clinical…
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Journal Article
The protective effect of neurointerventional recanalization on the neurovascular unit in acute ischemic stroke and its correlation with serum GFAP and NfL levels
AimThis study aimed to investigate the neuroprotective mechanisms of mechanical thrombectomy (MT) by evaluating its effects on the neurovascular unit (NVU) and correlating these effects with dynamic changes in serum biomarkers in patients with acute ischemic stroke (AIS).MethodsA prospective cohort…
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Journal Article
Correlation between atrial cardiomyopathy and total burden of cerebral small vessel disease in patients with acute ischemic stroke
BackgroundAtrial cardiomyopathy (ACM) and cerebral small vessel disease (CSVD) share common risk factors (e.g., hypertension, diabetes, dyslipidemia, aging) and pathophysiological mechanisms (e.g., inflammatory response, oxidative stress).ObjectiveThis study aimed to investigate the relationship…
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Journal Article
This is a personal journey: a qualitative study on the influencing factors of home-based exercise rehabilitation behavior among stroke survivors
BackgroundAdherence with home-based exercise rehabilitation among stroke patients is generally low. Promoting a behavioral shift from passive compliance to active participation in home-based exercise rehabilitation is crucial to address this challenge. However, there is currently a lack of in-depth…
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Journal Article
Impact of early vs. late tracheostomy on clinical outcomes in mechanically ventilated patients with intracerebral hemorrhage extending into the ventricles: a retrospective cohort study based on quantitative assessment of parenchymal and intraventricular hematoma volumes
BackgroundThe optimal timing for tracheostomy in patients with intracerebral hemorrhage extending into the ventricles who require mechanical ventilation remains controversial, and there is a paucity of evidence to guide clinical practice. This study aimed to elucidate the impact of early vs. late…
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Journal Article
Predictors of initiating high-efficacy vs. platform therapies as first-line disease-modifying treatment in multiple sclerosis
BackgroundThe therapeutic landscape of multiple sclerosis (MS) is rapidly evolving, with increasing emphasis on early initiation of high-efficacy disease-modifying therapies (heDMTs). However, real-world data on predictors of first-line heDMT use and its outcomes remain scarce in the Middle…
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Journal Article
Considering neurophysiological mechanisms of dual-tasking in people with multiple sclerosis: an exploratory, cross-sectional small-N study
IntroductionDual-tasking is an emerging topic of study within the field of multiple sclerosis (MS) rehabilitation. Past research on dual-task performance among people with MS (PwMS) is limited by methodological differences and minimal consideration of underlying neurophysiology. Related studies…
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Journal Article
Dose-response meta-analysis of plasma TMAO and stroke: validated linear risk threshold at 3.0 μmol/L
BackgroundStroke, especially the ischemic type, remains a leading global cause of death and disability, with modifiable risk factors offering prevention opportunities. Trimethylamine N-oxide (TMAO), a gut-derived metabolite, promotes vascular damage and is linked to stroke risk. Although prior…
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Journal Article
Nomogram to predict symptomatic intracranial hemorrhage after mechanical thrombectomy in patients with intracranial atherosclerosis-related large-vessel occlusion
BackgroundDespite significant advancements in endovascular treatment (EVT) over the past decade, symptomatic intracerebral hemorrhage (sICH) persists as a serious complication, especially in patients with acute ischemic stroke (AIS) related to intracranial atherosclerotic stenosis (ICAS), which is…
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Journal Article
Serum neurofilament light chain and disease-modifying treatment as predictors of cognitive decline in multiple sclerosis
BackgroundCognitive impairment (CI) is a prevalent and early problem in multiple sclerosis (MS). Its detection and monitoring might help prevent cognitive decline and potentially inform treatment decisions.ObjectiveThe aim of this study was to analyze the possible associations of cognitive decline…
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Journal Article
Meta-analysis for the associations of serum C-reactive protein with delirium risk
BackgroundThis meta-analysis aimed to evaluate the association between serum C-reactive protein (CRP) levels and delirium risk, encompassing postoperative delirium (POD) and delirium secondary to other medical conditions.MethodsA systematic search was conducted across PubMed, Web of Science, and…
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Journal Article
Prediction of collateral circulation grading and functional outcomes in acute ischemic stroke using FLAIR vascular hyperintensity combined with multimodal CT parameters
Background/objectivesThe variability in acute ischemic stroke (AIS) outcomes is closely associated with collateral circulation status. While fluid-attenuated inversion recovery vascular hyperintensity (FVH) and multimodal CT parameters (e.g., rLMC score, rCBV) were associated with 90-day functional…
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Journal Article
Toward a “green” brain health agenda: establishing short- and long-term goals for the field of neurology in a changing climate
The global burden of neurological disease is rising amid an aging population and accelerating climate change, yet environmental determinants of brain health remain underrecognized within neurology. Climate-related factors—including air pollution, extreme heat, environmental contaminants, and…
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Journal Article
Association between endothelial function and early neurological improvement in atrial fibrillation-related ischemic stroke
BackgroundUnderstanding the factors related to early neurological improvement (ENI) is crucial in managing atrial fibrillation-related ischemic stroke (AF-stroke), as ENI indicates better long-term outcomes. We investigated the association between endothelial function, measured via flow-mediated…
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Journal Article
Deep learning-based prediction of TERT mutation status from MRI for glioma molecular subtyping
BackgroundThis study aimed to develop and validate a deep learning model based on preoperative MRI to non-invasively predict Telomerase Reverse Transcriptase (TERT) promoter mutation status in glioma patients.MethodsA retrospective cohort of 100 patients with histologically confirmed high-grade…
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Journal Article
Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain
IntroductionRNA methylation modifications, including N1 methyladenosine (m1A), N6-methyladenosine (m6A), 5-methylcytosine (m5C), and 7-methylguanosine (m7G) methylation, have been increasingly implicated in nervous system disorders. The aim of this study was to explore key m1A/m6A/m5C/m7G-related…
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