7 hasil untuk "Hafsa Amat-ur-Rasool"

Designing Second Generation Anti-Alzheimer Compounds as Inhibitors of Human Acetylcholinesterase: Computational Screening of Synthetic Molecules and Dietary Phytochemicals

Hafsa Amat-ur-Rasool; Mehboob Ahmed

PLOS ONE, Vol. 10 No. 9 · 2015 · Inggris · PLOS Scopus

Alzheimer's disease (AD), a big cause of memory loss, is a progressive neurodegenerative disorder. The disease leads to irreversible loss of neurons that result in reduced level of acetylcholine neurotransmitter (ACh). The reduction of ACh level impairs brain functioning. One aspect of AD therapy…

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Computational Prediction and Analysis of Envelop Glycoprotein Epitopes of DENV-2 and DENV-3 Pakistani Isolates: A First Step towards Dengue Vaccine Development

Hafsa Amat-ur-Rasool; Anam Saghir; Muhammad Idrees

PLOS ONE, Vol. 10 No. 3 · 2015 · Inggris · PLOS Scopus

Dengue fever of tropics is a mosquito transmitted devastating disease caused by dengue virus (DENV). There is no effective vaccine available, so far, against any of its four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). There is a need for the development of preventive and therapeutic vaccines…

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Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease

Hafsa Amat-ur-Rasool; Mehboob Ahmed; Shahida Hasnain dkk.

Brain Sciences, Vol. 11 No. 2 · 2021 · Inggris · DOAJ Scopus

Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs). Herein, the potency of the ChEIs, donepezil, tacrine, berberine, and galantamine to inhibit human…

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease

Hafsa Amat-ur-Rasool; Mehboob Ahmed; Shahida Hasnain dkk.

Current Issues in Molecular Biology, Vol. 44 No. 1 · 2021 · Inggris · DOAJ Scopus

The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is an unmet need to produce ChEIs with improved…

Potential Nutraceutical Properties of Leaves from Several Commonly Cultivated Plants

Hafsa Amat-ur-Rasool; Fenella Symes; David Tooth dkk.

Biomolecules, Vol. 10 No. 11 · 2020 · Inggris · DOAJ Scopus

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase inhibitors (ChEIs) are required. Herein, we…