6 hasil untuk "Hein Putter"

A tutorial on frailty models

Theodor Adrian Balan; Hein Putter

Statistical Methods in Medical Research · 2020 · Inggris · OpenAlex Scopus

The hazard function plays a central role in survival analysis. In a homogeneous population, the distribution of the time to event, described by the hazard, is the same for each individual. Heterogeneity in the distributions can be accounted for by including covariates in a model for the hazard, for…

Locoregional Failure During and After Short-course Radiotherapy Followed by Chemotherapy and Surgery Compared With Long-course Chemoradiotherapy and Surgery

Esmée A. Dijkstra; Per J. Nilsson; Geke A.P. Hospers dkk.

Annals of Surgery · 2023 · Inggris · OpenAlex Scopus

OBJECTIVE: To analyze risk and patterns of locoregional failure (LRF) in patients of the RAPIDO trial at 5 years. BACKGROUND: Multimodality treatment improves local control in rectal cancer. Total neoadjuvant treatment (TNT) aims to improve systemic control while local control is maintained. At 3…

Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy

Alicia León‐Castillo; Stephanie M. de Boer; Melanie E. B. Powell dkk.

Journal of Clinical Oncology · 2020 · Inggris · OpenAlex Scopus

PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with high-risk endometrial cancer (EC)…

PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer

Anne Sophie V M van den Heerik; Nanda Horeweg; Remi A. Nout dkk.

International Journal of Gynecological Cancer · 2020 · Inggris · OpenAlex Scopus

BACKGROUND: Vaginal brachytherapy is currently recommended as adjuvant treatment in patients with high-intermediate risk endometrial cancer to maximize local control and has only mild side effects and no or limited impact on quality of life. However, there is still considerable overtreatment and…

Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial

Stefanie de Groot; Rieneke T. Lugtenberg; Danielle Cohen dkk.

Nature Communications · 2020 · Inggris · OpenAlex Scopus

Abstract Short-term fasting protects tumor-bearing mice against the toxic effects of chemotherapy while enhancing therapeutic efficacy. We randomized 131 patients with HER2-negative stage II/III breast cancer, without diabetes and a BMI over 18 kg m −2 , to receive either a fasting mimicking diet…

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Renu R. Bahadoer; Esmée A. Dijkstra; Boudewijn van Etten dkk.

The Lancet Oncology · 2020 · Inggris · OpenAlex Scopus