21 hasil untuk "I-Ching Sam"

Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera

Chong-Long Chua; I-Ching Sam; Andres Merits dkk.

PLOS Neglected Tropical Diseases, Vol. 10 No. 8 · 2016 · Inggris · PLOS Scopus

Background: Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus which causes epidemics of fever, severe joint pain and rash. Between 2005 and 2010, the East/Central/South African (ECSA) genotype was responsible for global explosive outbreaks across India, the Indian Ocean and Southeast…

The neutralizing role of IgM during early Chikungunya virus infection

Chong-Long Chua; I-Ching Sam; Chun-Wei Chiam dkk.

PLOS ONE, Vol. 12 No. 2 · 2017 · Inggris · PLOS Scopus

The antibody isotype IgM appears earlier than IgG, within days of onset of symptoms, and is important during the early stages of the adaptive immune response. Little is known about the functional role of IgM during infection with chikungunya virus (CHIKV), a recently reemerging arbovirus that has…

Immunodominant IgM and IgG Epitopes Recognized by Antibodies Induced in Enterovirus A71-Associated Hand, Foot and Mouth Disease Patients

Kam Leng Aw-Yong; I-Ching Sam; Mia Tuang Koh dkk.

PLOS ONE, Vol. 11 No. 11 · 2016 · Inggris · PLOS Scopus

Enterovirus A71 (EV-A71) is one of the main causative agents of hand, foot and mouth disease (HFMD). Unlike other enteroviruses that cause HFMD, EV-A71 is more frequently associated with severe neurological complications and fatality. To date, no effective licensed antivirals are available to…

Enterovirus A71 DNA-Launched Infectious Clone as a Robust Reverse Genetic Tool

Chee Wah Tan; Han Kang Tee; Michelle Hui Pheng Lee dkk.

PLOS ONE, Vol. 11 No. 9 · 2016 · Inggris · PLOS Scopus

Enterovirus A71 (EV-A71) causes major outbreaks of hand, foot and mouth disease, and is occasionally associated with neurological complications and death in children. Reverse genetics is widely used in the field of virology for functional study of viral genes. For EV-A71, such tools are limited to…

Nationwide Survey of Knowledge and Health Beliefs regarding Human Papillomavirus among HPV-Vaccinated Female Students in Malaysia

Li Ping Wong; Raja Nur Amalina Raja Muhammad Yusoff; Zobaida Edib dkk.

PLOS ONE, Vol. 11 No. 9 · 2016 · Inggris · PLOS Scopus

The National HPV Immunization Programme, which offers free human papillomavirus (HPV) vaccines to teenaged female students, was launched in Malaysia in 2010. HPV vaccination paired with adequate knowledge about HPV infection provides the best protection against cervical cancer. To identify the…

Cyclical Patterns of Hand, Foot and Mouth Disease Caused by Enterovirus A71 in Malaysia

NMN NikNadia; I-Ching Sam; Sanjay Rampal dkk.

PLOS Neglected Tropical Diseases, Vol. 10 No. 3 · 2016 · Inggris · PLOS Scopus

Enterovirus A71 (EV-A71) is an important emerging pathogen causing large epidemics of hand, foot and mouth disease (HFMD) in children. In Malaysia, since the first EV-A71 epidemic in 1997, recurrent cyclical epidemics have occurred every 2–3 years for reasons that remain unclear. We hypothesize…

Risk Factors for Enterovirus A71 Seropositivity in Rural Indigenous Populations in West Malaysia

NMN NikNadia; I-Ching Sam; Nasibah Khaidir dkk.

PLOS ONE, Vol. 11 No. 2 · 2016 · Inggris · PLOS Scopus

Enterovirus A71 (EV-A71), which is transmitted by the fecal-oral route, causes hand, foot and mouth disease and, rarely, severe neurological complications. In Malaysia, the indigenous rural community (Orang Asli) has a high prevalence of parasitic diseases due to poor sanitation, water supply and…

Clinical Risk Factors for Life-Threatening Lower Respiratory Tract Infections in Children: A Retrospective Study in an Urban City in Malaysia

Anna Marie Nathan; Fairuz Rani; Rachel Jiun Yi Lee dkk.

PLoS ONE, Vol. 9 No. 10 · 2014 · Inggris · PLOS Scopus

Aim: Lower respiratory tract infections (LRTIs) are an important cause of morbidity and mortality, especially in low income countries. The aim of this study was to determine risk factors of life-threatening LRTIs in hospitalised children in Malaysia. Methods: This retrospective study included…

Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014

Xiang Yong Oong; Kim Tien Ng; Joon Ling Tan dkk.

PLOS ONE, Vol. 12 No. 1 · 2017 · Inggris · PLOS Scopus

Reassortment of genetic segments between and within influenza B lineages (Victoria and Yamagata) has been shown to generate novel reassortants with unique genetic characteristics. Based on hemagglutinin (HA) and neuraminidase (NA) genes, recent surveillance study has identified reassortment…

Rhinovirus/enterovirus was the most common respiratory virus detected in adults with severe acute respiratory infections pre-COVID-19 in Kuala Lumpur, Malaysia

Yoong Min Chong; Yoke Fun Chan; Mohamad Fadhil Hadi Jamaluddin dkk.

PLOS ONE, Vol. 17 No. 9 · 2022 · Inggris · PLOS Scopus

Background: Severe acute respiratory infections (SARI) pose a great global burden. The contribution of respiratory viruses to adult SARI is relatively understudied in Asia. We aimed to determine viral aetiology of adult SARI patients in Kuala Lumpur, Malaysia. Methods: The prevalence of 20 common…

Susceptibility of Aedes albopictus , Ae . aegypti and human populations to Ross River virus in Kuala Lumpur, Malaysia

Jolene Yin Ling Fu; Chong Long Chua; Athirah Shafiqah Abu Bakar dkk.

PLOS Neglected Tropical Diseases, Vol. 17 No. 6 · 2023 · Inggris · PLOS Scopus

Background: Emerging arboviruses such as chikungunya and Zika viruses have unexpectedly caused widespread outbreaks in tropical and subtropical regions recently. Ross River virus (RRV) is endemic in Australia and has epidemic potential. In Malaysia, Aedes mosquitoes are abundant and drive dengue…

Correction: Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia

Limin Li; Yen Yen Woo; Jessie Anne de Bruyne dkk.

PLOS ONE, Vol. 13 No. 12 · 2018 · Inggris · PLOS Scopus

Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia

Li Min Lim; Yen Yen Woo; Jessie Anne de Bruyne dkk.

PLOS ONE, Vol. 13 No. 10 · 2018 · Inggris · PLOS Scopus

Objectives: To describe the severity, human adenovirus (HAdV) type and respiratory morbidity following adenovirus pneumonia in children. Methodology: Retrospective review of children under 12 years of age, admitted with HAdV pneumonia, between January 2011 and July 2013, in a single centre in…

SARS-CoV-2 lineage B.6 was the major contributor to early pandemic transmission in Malaysia

Yoong Min Chong; I-Ching Sam; Jennifer Chong dkk.

PLOS Neglected Tropical Diseases, Vol. 14 No. 11 · 2020 · Inggris · PLOS Scopus

Malaysia had 10,219 confirmed cases of COVID-19 as of September 20, 2020. About 33% were associated with a Tablighi Jamaat religious mass gathering held in Kuala Lumpur between February 27 and March 3, 2020, which drove community transmission during Malaysia’s second wave. We analysed genome…

Prospective Evaluation of Antibody Response post COVID-19 vaccination in older persons ≧ 60 years old (PEARL 60): A longitudinal 15-months study in a tertiary centre in Malaysia

Kejal Hasmukharay; Ashutosh Kumar Verma; Kiirtaara Aravindhan dkk.

PLOS One, Vol. 21 No. 2 · 2026 · Inggris · PLOS Scopus

Older adults exhibit heterogeneous immune responses to COVID-19 vaccination, yet the relative contributions of age, comorbidity, vaccine platform, and infection history to antibody durability remain incompletely defined. Understanding these determinants is essential to inform booster strategies in…

Genotypic and Phenotypic Characterization of Chikungunya Virus of Different Genotypes from Malaysia

I-Ching Sam; Shih-Keng Loong; Jasmine Chandramathi Michael dkk.

PLoS ONE, Vol. 7 No. 11 · 2012 · Inggris · PLOS Scopus

Background: Mosquito-borne Chikungunya virus (CHIKV) has recently re-emerged globally. The epidemic East/Central/South African (ECSA) strains have spread for the first time to Asia, which previously only had endemic Asian strains. In Malaysia, the ECSA strain caused an extensive nationwide outbreak…

Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice

Han Kang Tee; Chee Wah Tan; Thinesshwary Yogarajah dkk.

PLOS Pathogens, Vol. 15 No. 11 · 2019 · Inggris · PLOS Scopus

Enterovirus A71 (EV-A71) causes hand, foot and mouth disease epidemics with neurological complications and fatalities. However, the neuropathogenesis of EV-A71 remains poorly understood. In mice, adaptation and virulence determinants have been mapped to mutations at VP2-149, VP1-145 and VP1-244. We…

A change in circulating chikungunya virus variant impacts Aedes aegypti vector competence and spatiotemporal distribution of disease in Malaysia

Izzati Kausar Azman; Yoke Fun Chan; Chong Long Chua dkk.

PLOS Neglected Tropical Diseases, Vol. 18 No. 10 · 2024 · Inggris · PLOS Scopus

Background: In 2008–2010, Malaysia experienced a nationwide chikungunya virus (CHIKV) outbreak caused by the Indian Ocean lineage E1-226V (valine) variant, adapted to Aedes albopictus. In 2017–2022, transition to an E1-226A (alanine) variant occurred. Ae. albopictus prevails in rural areas, where…

Spatio-temporal dynamics of hand, foot and mouth disease in Malaysia, 2009–2019

Victoria M. Cox; Rohani Jahis; Rehan Shuhada Abu Bakar dkk.

PLOS Neglected Tropical Diseases, Vol. 19 No. 6 · 2025 · Inggris · PLOS Scopus

Hand, foot and mouth disease (HFMD) is endemic in Asia-Pacific. There is geographic variability in the timing of HFMD outbreaks throughout the year across the region, and seasonality becomes less clear towards tropical regions. We used syndromic HFMD case surveillance data from 2009 to 2019 (N =…

Cross-sectional study of influenza trends and costs in Malaysia between 2016 and 2018

Sharifa Ezat Wan Puteh; Mohd Shafiq Aazmi; Muhammad Nazri Aziz dkk.

PLOS ONE, Vol. 19 No. 3 · 2024 · Inggris · PLOS Scopus

Background and objectives: While influenza circulates year-round in Malaysia, research data on its incidence is scarce. Yet, this information is vital to the improvement of public health through evidence-based policies. In this cross-sectional study, we aimed to determine the trends and financial…