6 hasil untuk "Igor Odintsov"
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Artikel Jurnal
Two Cases of Akkadian Influence in Isaiah 50
This article investigates two probable cases of Akkadian linguistic influence in Isa 50 and asks why the prophet employs Akkadian attested phraseology where standard biblical alternatives were available. Using the comparative Semitic philological approach associated with Moshe Held—prioritising…
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Artikel Jurnal
NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors
Romel Somwar et al. find that cancer-causing NTRK gene fusions resistant to one form of inhibitor therapy can be resistant to other inhibitor types. Using molecular simulations, they show that some NTRK1 mutations resistant to the type I inhibitor larotrectinib are hypersensitive to the type II…
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Artikel Jurnal
RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals a role for MYC upregulation
Multi-kinase RET inhibitors, such as cabozantinib and RXDX-105, are active in lung cancer patients with RET fusions; however, the overall response rates to these two drugs are unsatisfactory compared to other targeted therapy paradigms. Moreover, these inhibitors may have different efficacies…
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Artikel Jurnal
Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. The paucity of DSRCT disease models has hampered…