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Communications Biology
Scopus
ISSN 2399-3642 · Nature Portfolio · 9.085 artikel di indeks
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Artikel Jurnal
T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history
Abstract Conventional T cells recognize peptides presented by the human leukocyte antigen (HLA) proteins through their T cell receptors (TCRs). Given that thousands of HLA proteins have been discovered, each presenting thousands of different peptides, decoding the cognate HLA protein of a TCR…
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NLRP10 engages oxidized DNA through a Schiff-base mechanism and dissociates from NLRP3 upon inflammasome activation
Abstract Mitochondrial DNA release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly. Here, we demonstrate that NLRP3 is involved in the release of D-loop mtDNA into the cytosol. We…
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Development of a novel humanized gut-brain axis model as a tool toward personalized nutrition
Abstract Intestinal luminal microbial metabolites affect tryptophan and serotonin metabolism, and cross or modify the blood-brain barrier (BBB). Understanding those mechanisms further necessitates integrated gut-brain axis model systems. Using an ex vivo-in vitro approach, H2O2-stressed or…
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The neural correlates of shared and individual experience
Abstract We set out to explore the neural correlates of individual-specific experiences. We propose an approach through which we compute individual-specific dynamics of functional connectivity states. These dynamics do not require estimation of common states across individuals and can be directly…
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Artikel Jurnal
Population genomics reveals an ancient origin of heartworms in canids
Abstract Heartworms (Dirofilaria immitis) are parasitic nematodes that cause significant cardiopulmonary-associated morbidity and mortality in canids worldwide. The global spread of heartworms is believed to have occurred alongside the dispersal of modern domesticated dogs over the past few hundred…
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Artikel Jurnal
Radiotherapy plus neoadjuvant and concomitant IL-13Rα2-directed immunotoxin therapy for diffuse intrinsic pontine glioma
Abstract Radiotherapy (RT) is the standard-of-care for diffuse intrinsic pontine glioma (DIPG); however, it functions as a palliative treatment. Interleukin 13 receptor subunit alpha 2 (IL-13Rα2) is upregulated in most DIPG tumors, posing a promising therapeutic target. Immunotherapies harnessing…
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Establishing functional giant Dictyostelium cells reveals front–rear polarity in intracellular signaling
Abstract Intracellular signaling dynamics are often obscured by the spatial and temporal limitations of cell size. Here, we developed a method to enlarge Dictyostelium discoideum cells by partial cytokinesis inhibition, generating multinucleated yet functional giant cells. These cells retained…
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BLM and FANCJ role in the response to G-quadruplex-dependent telomeric replicative stress
Abstract DNA G-quadruplexes (G4s) spontaneously arise in guanine-rich regions such as telomeres. Although G4s regulate essential biological process, their persistence can interfere with DNA metabolism and induce replication stress (RS). Helicases such as BLM and FANCJ play key roles in resolving G4…
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Artikel Jurnal
The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women
Abstract The menstrual cycle impacts food intake, peripheral metabolism, and brain function. One well-known central regulator of eating behavior is the hormone insulin. Here, we show that the responsiveness of functional brain networks to central insulin varies dynamically across the menstrual…
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Temporal sleep spindle clustering and slow-oscillation coupling in motor memory consolidation and generalization
Abstract Sleep benefits memory consolidation through periodic sleep spindle activity and associated memory reactivations. The temporal organization of spindles in “trains” is considered a critical sleep mechanism for the timed and repeated reactivation of memories. Evidence suggests that a timely…
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Artikel Jurnal
Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration
Abstract Mesenchymal stem cell-derived extracellular matrix (mECM) is increasingly recognized in tissue regeneration due to its high biocompatibility, controllability, and customizability. In musculoskeletal diseases, mECM provides a 3D scaffold mimicking the natural cellular environment and…
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Artikel Jurnal
Advancing spatial cellular communication inference with ligand diffusion and transport model
Abstract Cell-cell communication is fundamental for coordinating cellular activities, maintaining tissue homeostasis, and supporting physiological functions. This complex process is primarily mediated by ligand-receptor interactions, in which ligands bind to cognate receptors to trigger downstream…
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Artikel Jurnal
Cortical hierarchy and aphasia severity: the sensorimotor–association gradient modulates lesion effects within language-specific networks
Abstract Aphasia severity after stroke varies widely and is not fully explained by lesion size or location. We propose that incorporating the brain’s sensorimotor-association (S-A) gradient, reflecting cortical hierarchy, offers a biologically grounded framework for predicting language outcomes. In…
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High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae
Abstract Understanding the behavioral and morphological dynamics of moving model organisms like the zebrafish larvae requires accurate, high-throughput 3D analysis. However, traditional single-view 2D video tracking fails to capture the full scope of natural 3D movements and postural dynamics…
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Decoding gray matter, large-scale analysis of brain cell morphometry to inform microstructural modeling of diffusion MR signals
Abstract Grey matter structure is central to neuroscience, as cellular morphology varies by type and is influenced by neurological conditions. Understanding these variations is essential for studying brain function and disease mechanisms. Diffusion-weighted MRI (dMRI) offers a non-invasive way to…
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Artikel Jurnal
Land and climate suitability for West Nile virus in Atlantic archipelagos guided by historical data from Europe
Abstract West Nile (WNV) is a zoonotic mosquito-borne virus with an expanding geographical and epidemic activity worldwide. Computational studies have contributed to the understanding of factors driving WNV occurrence, particularly in North America and Europe. Archipelagos have largely been…
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Artikel Jurnal
Multiple active-sites editing of adenylation domains of srfA operon for constructing diverse surfactin lipopeptide
Abstract The srfA operon, which encodes the surfactin synthase SrfA in Bacillus rhizobacteria, is essential for surfactin biosynthesis. As a typical non-ribosomal peptide synthetase (NRPS), the adenylation domain of SrfA determines the structure of the synthesized peptide. A major challenge in the…
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Artikel Jurnal
scXDR: drug response prediction across single-cell datasets via heterogeneous network transfer learning
Abstract Drug response prediction at the single-cell level provides guidance for drug development and treatment. Existing methods typically rely on integrating data from bulk RNA sequencing and single-cell RNA sequencing, transferring overall cell line drug response labels to individual cells…
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Artikel Jurnal
Targeting microglial inflammation in Parkinson’s disease: irisin activates PAFAH1B1-RAGE ubiquitination and TFEB-dependent autophagy to alleviate neurodegeneration
Abstract Investigate irisin’s therapeutic potential in Parkinson’s disease (PD). Clinical data from 120 PD patients and 120 controls were analyzed. MPTP-induced PD mice and LPS-stimulated BV2 microglia models were used. In vivo, mice were divided into control, PD, and PD + Irisin groups for…
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