15 results for "Klara Tenner-Racz"

Absence of HIV-1 Evolution in the Gut-Associated Lymphoid Tissue from Patients on Combination Antiviral Therapy Initiated during Primary Infection

Teresa H. Evering; Saurabh Mehandru; Paul Racz et al.

PLoS Pathogens, Vol. 8 No. 2 · 2012 · English · PLOS Scopus

Mucosal mononuclear (MMC) CCR5+CD4+ T cells of the gastrointestinal (GI) tract are selectively infected and depleted during acute HIV-1 infection. Despite early initiation of combination antiretroviral therapy (cART), gut-associated lymphoid tissue (GALT) CD4+ T cell depletion and activation…

Also available at: DOAJ

Detection of Puumala Hantavirus Antigen in Human Intestine during Acute Hantavirus Infection

Joerg Latus; Klara Tenner-Racz; Paul Racz et al.

PLoS ONE, Vol. 9 No. 5 · 2014 · English · PLOS Scopus

Background: Puumala virus (PUUV) is the most important hantavirus species in Central Europe. Nephropathia epidemica (NE), caused by PUUV, is characterized by acute renal injury (AKI) with thrombocytopenia and frequently gastrointestinal symptoms. Methods: 456 patients with serologically and…

Also available at: DOAJ

Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Saurabh Mehandru; Michael A Poles; Klara Tenner-Racz et al.

PLoS Medicine, Vol. 3 No. 12 · 2006 · English · PLOS Scopus

Background: During acute and early HIV-1 infection (AEI), up to 60% of CD4+ T cells in the lamina propria of the lower gastrointestinal (GI) tract are lost as early as 2–4 wk after infection. Reconstitution in the peripheral blood during therapy with highly active antiretroviral therapy (HAART) is…

Also available at: DOAJ

Correction: Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Saurabh Mehandru; Michael A Poles; Klara Tenner-Racz et al.

PLoS Medicine, Vol. 3 No. 12 · 2006 · English · PLOS Scopus

Immunogenicity of DNA Vaccines Encoding Simian Immunodeficiency Virus Antigen Targeted to Dendritic Cells in Rhesus Macaques

Matthias Tenbusch; Ralf Ignatius; Godwin Nchinda et al.

PLoS ONE, Vol. 7 No. 6 · 2012 · English · PLOS Scopus

Background: Targeting antigens encoded by DNA vaccines to dendritic cells (DCs) in the presence of adjuvants enhances their immunogenicity and efficacy in mice. Methodology/Principal Findings: To explore the immunogenicity of this approach in non-human primates, we generated a single chain antibody…

Also available at: DOAJ

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

Christiane Stahl-Hennig; Martin Eisenblätter; Edith Jasny et al.

PLoS Pathogens, Vol. 5 No. 4 · 2009 · English · PLOS Scopus

Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular…

Also available at: DOAJ

Correction: Epizootic Emergence of Usutu Virus in Wild and Captive Birds in Germany

Norbert Becker; Hanna Jöst; Ute Ziegler et al.

PLoS ONE, Vol. 7 No. 8 · 2012 · English · PLOS Scopus

Also available at: DOAJ

Epizootic Emergence of Usutu Virus in Wild and Captive Birds in Germany

Norbert Becker; Hanna Jöst; Ute Ziegler et al.

PLoS ONE, Vol. 7 No. 2 · 2012 · English · PLOS Scopus

This study aimed to identify the causative agent of mass mortality in wild and captive birds in southwest Germany and to gather insights into the phylogenetic relationship and spatial distribution of the pathogen. Since June 2011, 223 dead birds were collected and tested for the presence of viral…

Also available at: DOAJ