175 hasil untuk "Li Xiuling"
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Strain-induced self-rolled-up microtubes for multifunctional on-chip microfluidic applications
On-chip microfluidics are characterized as miniaturized devices that can be either integrated with other components on-chip or can individually serve as a standalone lab-on-a-chip system for a variety of applications ranging from biochemical sensing to macromolecular manipulation. Heterogenous…
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Activation of Thromboxane A(2) Receptor (TP) Increases the Expression of Monocyte Chemoattractant Protein -1 (MCP-1)/Chemokine (C-C motif) Ligand 2 (CCL2) and Recruits Macrophages to Promote Invasion of Lung Cancer Cells
Thromboxane synthase (TXAS) and thromboxane A(2) receptor (TP), two critical components for thromboxane A(2) (TXA(2)) signaling, have been suggested to be involved in cancer invasion and metastasis. However, the mechanisms by which TXA(2) promotes these processes are still unclear. Here we show…
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Antibody conjugation via one and two C-terminal selenocysteines
Conventional antibody conjugation methods generate antibody-drug conjugates that are heterogeneous mixtures with undefined stoichiometry and variable pharmacokinetic and pharmacodynamic properties. We have previously described a strategy to generate site-specific antibody conjugates by genetic…
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Prediction of the Invasiveness of Ground-Glass Nodules in Lung Adenocarcinoma by Radiomics Analysis Using High-Resolution Computed Tomography Imaging
BACKGROUND: Pure ground-glass nodules (pGGNs) have been considered inert tumors due to their biological behavior; however, their prognosis is not completely consistent because of differences in internal pathological component. The aim of this study was to explore whether radiomics can be used to…
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Precise detection of differential RNA editing sites across varied biological conditions using the CADRES pipeline
RNA editing is an important post-transcriptional modification for gene regulation and protein diversity. Detecting these modifications, especially Differential Variants on RNA (DVRs), presents significant challenges due to interference from sequencing errors and genetic variants. Currently, despite…
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Pseudo-Static Experiment and Analysis on Seismic Behavior of the RC Columns Strengthened by GHPFRCC
Green high performance fiber reinforced cementitious composites (GHPFRCC) are a new class of sustainable cementitious composites, employing a high volume of fly ash to replace cement. In addition to increasing the sustainability of the construction environment, GHPFRCC exhibits a high tensile…
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Development and validation of a competitive risk model in patients with rectal cancer: based on SEER database
BACKGROUND: Rectal cancer is one of the most common malignancies. To predict the specific mortality risk of rectal cancer patients, we constructed a predictive nomogram based on a competing risk model. METHODS: The information on rectal cancer patients was extracted from the SEER database…
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The complete chloroplast genome sequence of Trapa incisa Sieb. & Zucc. (Lythraceae)
Trapa L., an annual floating-leaved herb, is widely distributed in the old world and has important edible and medicinal values. However, the taxonomy and phylogeny of Trapa are unclear. Here, we reported the complete chloroplast genome of a wild species with small nuts, T. incisa. The complete…
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Esophageal foreign bodies: a retrospective analysis of 275 cases
BACKGROUND: Esophageal foreign bodies, especially complex foreign bodies, are a clinical emergency that require a specific management strategy. The aim of this study was to analyze the clinical features of adult patients with esophageal foreign bodies, examine different endoscopic management…
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A Sortase A programmable phage display format for improved panning of Fab antibody libraries
Phage display of combinatorial antibody libraries is a versatile tool in the field of antibody engineering, with diverse applications including monoclonal antibody (mAb) discovery, affinity maturation, and humanization. To improve the selection efficiency of antibody libraries, we developed a new…
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Assessment of Reagents for Selenocysteine Conjugation and the Stability of Selenocysteine Adducts
Conventional antibody-drug conjugates (ADCs) are heterogeneous mixtures that have poor pharmacokinetic properties and decreased efficacy relative to homogenous ADCs. Furthermore, ADCs that are maleimide-based often have inadequate circulatory stability, which can result in premature drug release…
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Adsorption properties of modified eggshell on phosphorus in water
Modified eggshell adsorbent was prepared with 5% potassium permanganate solution to adsorb phosphorus in simulated wastewater. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were used to clarify their phosphorus removal mechanisms…
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An improved eye-covering technique: its impact on postoperative vision-related quality of life and anxiety in patients undergoing bilateral strabismus surgery: a non-randomized controlled trial
Objective: To investigate the effects of a modified eye-patching technique, which combines the use of an eye shield on one eye and an eye patch on the other, on the quality of life and anxiety levels of strabismus patients during the recovery period after binocular correction surgery. Methods: A…
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A genome-wide scan for signatures of selection in Chinese indigenous and commercial pig breeds
BACKGROUND: Modern breeding and artificial selection play critical roles in pig domestication and shape the genetic variation of different breeds. China has many indigenous pig breeds with various characteristics in morphology and production performance that differ from those of foreign commercial…
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Cation Substitution in Earth‐Abundant Kesterite Photovoltaic Materials
As a promising candidate for low‐cost and environmentally friendly thin‐film photovoltaics, the emerging kesterite‐based Cu(2)ZnSn(S,Se)(4) (CZTSSe) solar cells have experienced rapid advances over the past decade. However, the record efficiency of CZTSSe solar cells (12.6%) is still significantly…
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Thin‐Film Solar Cells: Cation Substitution in Earth‐Abundant Kesterite Photovoltaic Materials (Adv. Sci. 4/2018)
Low‐cost and environmentally friendly kesterite structural Cu(2)ZnSn(S,Se)(4) (CZTSSe) thin‐film solar cells have experienced a significant increase in power conversion efficiency from about 5% to a record of 12.6%. To further improve device performance, various cation substitution technologies…
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The complete chloroplast genome sequences of an endangered orchid species Paphiopedilum wenshanense (Orchidaceae)
Paphiopedilum wenshanense, a species of the family Orchidaceae, is endangered in the world with highly ornamental and biological value, the morphology of P. wenshanense is very similar to its relative species, P. bellatulum and P. concolor. However, there are few studies on the molecular biology…
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Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronaviruses
β-coronaviruses (β-CoVs), representative with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), depend on their highly glycosylated spike proteins to mediate cell entry and membrane fusion. Compared with the extensively identified N-glycosylation, less is known about O-glycosylation of…
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Pandemic preparedness of effective vaccines for the outbreak of newly H5N1 highly pathogenic avian influenza virus
• Analyzed the outbreak situation and viral characteristics of the newly H5N1 highly pathogenic avian influenza (HPAI) virus. • The current approval and research and development of the H5N1 HPAI vaccines were summarized. • Proposed vaccine development approaches against newly H5N1 virus, e.g…
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Bioinformatic Analysis of Apoptosis-Related Genes in Preeclampsia Using Public Transcriptomic and Single-Cell RNA Sequencing Datasets
PURPOSE: Apoptosis, which is crucial in preeclampsia (PE), affects trophoblast survival and placental function. We used transcriptomics and single-cell RNA sequencing (scRNA-seq) to explore apoptosis-related genes (ARGs) and their cellular mechanisms as potential PE biomarkers. PATIENTS AND…