5 hasil untuk "Li-Bo Cao"
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Artikel Jurnal
Lumpy skin disease virus LSDV087 positively regulates innate immune response by promoting oligomerization of MITA/STING
ABSTRACT Lumpy skin disease (LSD), caused by the lumpy skin disease virus (LSDV), is a contagious disease in cattle that poses a major threat to the global cattle industry. The functions of most LSDV-encoded proteins remain poorly characterized, particularly regarding their roles in regulating…
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Artikel Jurnal Teks lengkap
Lumpy skin disease virus protein LSDV122 impairs IFN-I receptor complex formation to evade host innate immunity
Lumpy skin disease virus (LSDV) is a pathogenic poxvirus that causes systemic disease in cattle. Although LSDV encodes multiple proteins that are predicted to regulate host defense, the underlying mechanisms of its immune evasion strategies remain largely elusive. Here we identify the LSDV-encoded…
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Artikel Jurnal
Lumpy skin disease virus LSDV001 protein positively regulates inflammatory response by promoting assembly of the TAK1-TAB2/3 complex
ABSTRACT Lumpy skin disease (LSD) is an emerging transboundary viral disease of livestock caused by the lumpy skin disease virus (LSDV), which has caused substantial economic losses and negatively impacted veterinary public health. The underlying pathogenic mechanisms remain poorly understood…
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Artikel Jurnal
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone
Abstract Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice. Progesterone induces downstream antiviral genes and promotes innate antiviral response in…