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Journal of Virology
Scopus
ISSN 1098-5514 · American Society for Microbiology · 1.227 artikel di indeks
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Artikel Jurnal
mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 in animal models
ABSTRACT Monoclonal antibodies represent potent biological countermeasures against a wide range of human diseases; however, their clinical application and widespread use are limited by the high cost and complexity of antibody production and manufacturing. The mRNA-lipid nanoparticle (mRNA-LNP)…
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Artikel Jurnal
Impact of mutations affecting 4′-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus
ABSTRACT Venezuelan equine encephalitis virus (VEEV) is a prototypical encephalitic alphavirus. Members of the Alphavirus genus are found across the globe, transmitted by arthropod vectors, and cause significant disease burdens in humans and animals. There are currently no FDA-approved antivirals…
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Rift Valley fever virus activates multiple cell death pathways in neurons
ABSTRACT Neuronal injury and death contribute to long-term impairments and lethality during viral encephalitis. Rift Valley fever virus (RVFV), an arbovirus with epidemic potential, can manifest as late-onset encephalitis in humans, yet this disease outcome remains understudied. A lethal rodent…
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Fitness costs of phage-driven resistance mutations in Salmonella Enteritidis populations
ABSTRACT In the post-antibiotic era, bacteriophages have emerged as viable alternatives for combating antibiotic-resistant infections. Analogous to the emergence of antibiotic resistance, bacteria can also develop resistance to phages, a process often accompanied by a reduction in bacterial…
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Artikel Jurnal
Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice
ABSTRACT Secondary bacterial infections can significantly worsen the clinical course of influenza virus infections and are a leading cause of morbidity and mortality during seasonal influenza epidemics. Despite being a vaccine-preventable disease, influenza-related complications from secondary…
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Artikel Jurnal
ALDH1L1 suppresses the replication of porcine epidemic diarrhea virus by degrading viral nucleocapsid and envelope proteins
ABSTRACT Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic alphacoronavirus that causes severe diarrhea. It has a high fatality rate among newborn piglets, posing a considerable economic burden to the swine industry. Therefore, elucidating the host–pathogen interaction is warranted to…
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Artikel Jurnal
Measles vaccination perceptions and willingness to consider novel vaccination approaches in Cambodia’s floating villages
ABSTRACT Globally, the measles virus is making a comeback. Measles still claims the lives of over 100,000 children annually and remains a leading cause of preventable child mortality. Despite the availability of a highly effective and safe measles vaccine since the late 1960s, challenges in vaccine…
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Recombinant duck enteritis virus harboring the hemagglutinin genes of influenza virus rapidly induces specific cellular immunity in ducks
ABSTRACT Given that ducks serve as critical reservoirs for avian influenza viruses, achieving high immune coverage in duck flocks is essential for preventing the transmission of avian influenza viruses from wild birds to domestic poultry. Duck enteritis is the most important infectious disease that…
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Artikel Jurnal
Porcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication
ABSTRACT Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted…
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Artikel Jurnal
Filamentous virions act as non-infectious interfering particles to modulate papillomavirus infection
ABSTRACT Genus beta (β) human papillomaviruses (HPVs) potentially contribute to the development of non-melanoma skin cancer. Yet, comparatively little is known about their biology. In particular, details about initial infection, i.e., host cell entry, remain mostly elusive. During initial…
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Artikel Jurnal
Reovirus recombination is highly selective, and its profiles are primarily dictated by viral gene segment identity
ABSTRACT Recombination facilitates the generation of defective viral genomes (DVGs), truncated derivatives of the parental genome that require a helper virus to replicate. Recombination mechanisms are poorly understood for viruses with double-stranded RNA (dsRNA) genomes. Two strains of the dsRNA…
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Artikel Jurnal
Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations
ABSTRACT The 2009 pandemic H1N1 (pH1N1) influenza A virus (IAV) is a reassortant virus with two polymerase components, PA and PB2, originating from avian IAV. Avian IAV polymerase does not function efficiently in mammalian cells without host-adaptive mutations. The mechanism by which pH1N1…
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Global evolution dynamics of genotype VI NDVs and dissection of the biological properties of strains from the prevalent sub-genotypes
ABSTRACT As a unique antigenic variant of Newcastle disease virus (NDV) in pigeons, genotype VI NDVs cause serious disease in pigeons and pose a potential threat to domestic poultry. In this study, analyses of genetic variation and evolution of global genotype VI NDVs revealed the worldwide…
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Artikel Jurnal
Diving into the hidden viral world of marine protists
ABSTRACT As the most abundant biological entities in the ocean, viruses of microbes play important roles in regulating host population dynamics and influencing biogeochemical cycles. Metagenomic surveys have revealed an astounding reservoir of viral genetic diversity in single-celled marine…
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Artikel Jurnal
Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity
ABSTRACT Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early stages of infection. Despite variation…
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Artikel Jurnal
In vitro and in vivo characterization of a novel HSV-1 H129 neurotracer recombinant reveals dose-dependent replication and spread dynamics
ABSTRACT Understanding the organization and connectivity of brain circuits has been a major focus of neuroscience for decades, and viral vectors have been commonly utilized to map neural connections in animal models. The alpha-herpesvirus herpes simplex virus 1 (HSV-1) is one of the most studied…
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Artikel Jurnal
MPXV RNA-seq data provide evidence for protection of viral transcripts from APOBEC3 editing
ABSTRACT The 2022 outbreak of monkeypox virus (MPXV), a double-stranded DNA virus, is remarkable for an unusually high number of single-nucleotide substitutions compared to earlier strains, with a strong bias toward C→T and G→A transitions consistent with the APOBEC3 cytidine deaminase activity…
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Artikel Jurnal
Inhibition of type I interferon signaling is a conserved function of gamma-herpesvirus-encoded microRNAs
ABSTRACT Herpesviruses encode multiple factors that disarm innate immune signaling to evade host anti-viral responses. Several viral microRNAs expressed by Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) disrupt the induction of type I interferons (IFN) and/or the…
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Artikel Jurnal
Autographa californica multiple nucleopolyhedrovirus e18 is essential for the formation of normal intranuclear membrane microvesicles and intranuclear envelopment and nuclear egress of nucleocapsids
ABSTRACT Autographa californica multiple nucleopolyhedrovirus (AcMNPV) E18 (AC143, ODV-E18) is an envelope protein common to both occlusion-derived virions (ODVs) and budded virions (BVs). The e18 gene has been demonstrated to be essential for generating infectious BVs. However, its functional role…
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