15 hasil untuk "Li-Kai Cheng"
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Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha
BACKGROUND: It has been shown that estrogen is synthesized in the spinal dorsal horn and plays a role in modulating pain transmission. One of the estrogen receptor (ER) subtypes, estrogen receptor alpha (ERα), is expressed in the spinal laminae I-V, including substantia gelatinosa (SG, lamina II)…
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FXYD2, a γ subunit of Na(+),K(+)-ATPase, maintains persistent mechanical allodynia induced by inflammation
Na(+),K(+)-ATPase (NKA) is required to generate the resting membrane potential in neurons. Nociceptive afferent neurons express not only the α and β subunits of NKA but also the γ subunit FXYD2. However, the neural function of FXYD2 is unknown. The present study shows that FXYD2 in nociceptive…
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Fstl1 is involved in the regulation of radial glial scaffold development
BACKGROUND: Radial glial cells (RGCs), the instructive scaffolds for neuronal migration, are well characterized by their unique morphology and polarization; these cells extend elongated basal processes to the pial basement membrane (BM) and parallel to one another. However, little is known about…
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Reduction of follistatin-like 1 in primary afferent neurons contributes to neuropathic pain hypersensitivity
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Distinct Patterns of Interhemispheric Connectivity in Patients With Early- and Late-Onset Alzheimer’s Disease
Background: Early-onset Alzheimer’s disease (EOAD) presents a different clinical profile than late-onset Alzheimer’s disease (LOAD). Neuroimaging studies have demonstrated that patients with EOAD present more atrophy and functional disconnection than LOAD patients. However, it remains unknown…
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FXYD6 promotes thermal nociception by regulating TRPV1
FXYD6, an unnecessary auxiliary subunit of Na(+),K(+)-ATPase, is expressed in the nervous system. However, its functions remain largely unclear. In the present study, we find that FXYD6 is involved in the thermal nociception. FXYD6 was mainly expressed in small-diameter DRG neurons expressing…
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Embodied metacognition as strengthened functional connection between neural correlates of metacognition and dance in dancers: exploring creativity implications
IntroductionDance education fosters embodied metacognition, enhancing student’s creativity. This study examines the crucial role of functional connectivity (FC) between the neural correlates of metacognition (NCM) and dance (NCD) as the neurological foundation for dancers’ embodied metacognition…
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Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons
B-type natriuretic peptide (BNP) has been known to be secreted from cardiac myocytes and activate its receptor, natriuretic peptide receptor-A (NPR-A), to reduce ventricular fibrosis. However, the function of BNP/NPR-A pathway in the somatic sensory system has been unknown. In the present study, we…
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Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation
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Artikel Jurnal Teks lengkap
Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons
Morphine-induced analgesia and antinociceptive tolerance are known to be modulated by interaction between δ-opioid receptors (DORs) and μ-opioid receptors (MORs) in the pain pathway. However, evidence for expression of DORs in nociceptive small-diameter neurons in dorsal root ganglia (DRG) and for…
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Enhanced white matter fiber tract of the cortical visual system in visual artists: implications for creativity
IntroductionThis study aimed to examine the white matter characteristics of visual artists (VAs) in terms of visual creativity and the structural connectivity within the cortical visual system.MethodsDiffusion spectrum imaging was utilized to examine the changes in white matter within the cortical…
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Artikel Jurnal
Effect of ketamine intervention on hemodynamic responses in patients with treatment-resistant depression
Abstract Emerging evidence shows that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can produce rapid anti-suicidal effects in treatment-resistant depression, yet its underlying neuropharmacological mechanisms remain elusive. The present study aimed at investigating the therapeutic…
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Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity
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Artikel Jurnal Teks lengkap
Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity
Sensory neurons are distinguished by distinct signaling networks and receptive characteristics. Thus, sensory neuron types can be defined by linking transcriptome-based neuron typing with the sensory phenotypes. Here we classify somatosensory neurons of the mouse dorsal root ganglion (DRG) by…