8 results for "Li-Na Lin"

Dexmedetomidine protects against lung injury induced by limb ischemia‐reperfusion via the TLR4/MyD88/NF‐κB pathway

Bin‐Bin Xue; Bai‐Hui Chen; Ya‐Ning Tang et al.

Kaohsiung Journal of Medical Sciences, Vol. 35 No. 11 · 2019 · English · DOAJ Scopus

Abstract Dexmedetomidine (DEX) can protect the lung from ischemia‐reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. The aims of this study were to determine whether DEX attenuates lung injury following lower extremity I/R and to investigate the related toll‐like…

Salvia miltiorrhiza-Containing Chinese Herbal Medicine Combined With GnRH Agonist for Postoperative Treatment of Endometriosis: A Systematic Review and meta-Analysis

Qiang Gao; Lei Shen; Bei Jiang et al.

Frontiers in Pharmacology, Vol. 13 · 2022 · English · DOAJ Scopus

Background: Endometriosis is an estrogen-dependent gynecological inflammatory condition that may lead to infertility and recurrent pelvic pain. The purpose of this research was to determine the efficacy and safety of Salvia miltiorrhiza-containing Chinese herbal medicine (CHM) combined with…

Identification and Functional Analysis of Variant Haplotypes in the 5′-Flanking Region of Protein Phosphatase 2A-Bδ Gene

Hui-Feng Chen; Li-Na Lin; Yu-Xi Chen et al.

PLoS ONE, Vol. 7 No. 4 · 2012 · English · PLOS Scopus

Serine-threonine protein phosphatase 2A (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of cell growth, differentiation, and apoptosis. The substrate specificity and (sub)cellular localization of the PP2A holoenzymes are highly regulated by interaction with a family of…

Also available at: DOAJ

Cancer-testis antigen ACRBP: Cytotoxic response to its HLA-A2 restricted peptide and immune features in ovarian cancer

Xia Zeng; Li-Na Lin; Xiaoquan Li et al.

Human Vaccines & Immunotherapeutics, Vol. 21 No. 1 · 2025 · English · DOAJ Scopus

While our prior study identified the HLA-A *0201-restricted ACRBP epitope peptide and demonstrated its capacity to generate cytotoxic T lymphocytes (CTLs) in vitro, the clinical relevance of the peptide-induced T cell reactivity in ovarian cancer (OC) patients and the in vivo anti-tumor efficacy of…

Role of a Novel Functional Variant in the PPP2R1A Promoter on the Regulation of PP2A-Aalpha and the Risk of Hepatocellular Carcinoma

Hui-Feng Chen; Jian-Rong Mai; Jian-Xin Wan et al.

PLoS ONE, Vol. 8 No. 3 · 2013 · English · PLOS Scopus

Previously, we identified the genetic variant −241 (−/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may…

Also available at: DOAJ

Combined treatment with epigenetic agents enhances anti-tumor activity of MAGE-D4 peptide-specific T cells by upregulating the MAGE-D4 expression in glioma

Shui-Qing Bi; Qing-Mei Zhang; Xia Zeng et al.

Frontiers in Oncology, Vol. 12 · 2022 · English · DOAJ Scopus

ObjectiveThe study evaluated the efficacy of combined epigenetic drugs of decitabine (DAC), valproic acid (VPA), and trichostatin A (TSA) on immunotherapy against glioma.MethodsThe expression and prognosis of MAGE-D4 in glioma were analyzed online, and the expression of MAGE-D4 and HLA-A2 in glioma…