3 results for "Li-San Wang"

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Raffaella Nativio; Yemin Lan; Greg Donahue et al.

Nature Genetics · 2020 · English · OpenAlex Scopus

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel

Brian W. Kunkle; Michael A. Schmidt; Hans‐Ulrich Klein et al.

JAMA Neurology · 2020 · English · OpenAlex Scopus

Importance: Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in…

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Eric M. Reiman; Joseph F. Arboleda‐Velásquez; Yakeel T. Quiroz et al.

Nature Communications · 2020 · English · OpenAlex Scopus

Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer's…