1 hasil untuk "Li-gong Deng"

AXL inhibition prevents RPA2/CHK1-mediated homologous recombination to increase PARP inhibitor sensitivity in hepatocellular carcinoma

Kai-Min Li; Li-gong Deng; Li-Jun Xue dkk.

Heliyon, Vol. 10 No. 17 · 2024 · Inggris · DOAJ Scopus

Homologous recombination defects (HRD) render cells fail to repair DNA double-strand break (DSB), which causes synthetic lethality in these cells with punch by poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). Here, we reveal a receptor tyrosine kinase, AXL, whose inhibition leads to HRD in…