23 hasil untuk "Lin, Han"

Complex Collagen Fiber and Membrane Morphologies of the Whole Porcine Aortic Valve

Christopher A. Rock; Lin Han; Todd C. Doehring

PLoS ONE, Vol. 9 No. 1 · 2014 · Inggris · PLOS Scopus

Objectives: Replacement aortic valves endeavor to mimic native valve function at the organ, tissue, and in the case of bioprosthetic valves, the cellular levels. There is a wealth of information about valve macro and micro structure; however, there presently is limited information on the morphology…

Lack of Structural Variation but Extensive Length Polymorphisms and Heteroplasmic Length Variations in the Mitochondrial DNA Control Region of Highly Inbred Crested Ibis, Nipponia nippon

Xue-Lian He; Chang-Qing Ding; Jian-Lin Han

PLoS ONE, Vol. 8 No. 6 · 2013 · Inggris · PLOS Scopus

The animal mitochondrial DNA (mtDNA) length polymorphism and heteroplasmy are accepted to be universal. Here we report the lack of structural variation but the presence of length polymorphism as well as heteroplasmy in mtDNA control region of an endangered avian species – the Crested Ibis (Nipponia…

Meta-Analysis of RAGE Gene Polymorphism and Coronary Heart Disease Risk

Jun Wang; Lianjiang Zou; Zhigang Song dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Background: Recent data from human and animal studies have shown an upregulated expression of advanced glycosylation end product–specific receptor (RAGE) in human atherosclerotic plaques 1 and in retina, messangial, and aortic vessels, suggesting an important role of RAGE in the pathogenesis of…

Transcatheter Pulmonary Valve Replacement by Hybrid Approach Using a Novel Polymeric Prosthetic Heart Valve: Proof of Concept in Sheep

Ben Zhang; Xiang Chen; Tong-yi Xu dkk.

PLoS ONE, Vol. 9 No. 6 · 2014 · Inggris · PLOS Scopus

Background: Since 2000, transcatheter pulmonary valve replacement has steadily advanced. However, the available prosthetic valves are restricted to bioprosthesis which have defects like poor durability. Polymeric heart valve is thought as a promising alternative to bioprosthesis. In this study, we…

Redundant and specific roles of individual MIR172 genes in plant development

Heng Lian; Long Wang; Ning Ma dkk.

PLOS Biology, Vol. 19 No. 2 · 2021 · Inggris · PLOS Scopus

Evolutionarily conserved microRNAs (miRNAs) usually have high copy numbers in the genome. The redundant and specific roles of each member of a multimember miRNA gene family are poorly understood. Previous studies have shown that the miR156-SPL-miR172 axis constitutes a signaling cascade in…

Five Different Piscidins from Nile Tilapia, Oreochromis niloticus : Analysis of Their Expressions and Biological Functions

Kuan-Chieh Peng; Shu-Hua Lee; Ai-Ling Hour dkk.

PLoS ONE, Vol. 7 No. 11 · 2012 · Inggris · PLOS Scopus

Piscidins are antimicrobial peptides (AMPs) that play important roles in helping fish resist pathogenic infections. Through comparisons of tilapia EST clones, the coding sequences of five piscidin-like AMPs (named TP1∼5) of Nile tilapia, Oreochromis niloticus, were determined. The complete piscidin…

Concentration and Length Dependence of DNA Looping in Transcriptional Regulation

Lin Han; Hernan G. Garcia; Seth Blumberg dkk.

PLoS ONE, Vol. 4 No. 5 · 2009 · Inggris · PLOS Scopus

In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest. This action at a distance is often mediated by the formation of DNA loops: Binding at two or more sites on the DNA results in…

The steroid hormone 20-hydroxyecdysone binds to dopamine receptor to repress lepidopteran insect feeding and promote pupation

Xin-Le Kang; Jun-Ying Zhang; Di Wang dkk.

PLOS Genetics, Vol. 15 No. 8 · 2019 · Inggris · PLOS Scopus

Holometabolous insects stop feeding at the final larval instar stage and then undergo metamorphosis; however, the mechanism is unclear. In the present study, using the serious lepidopteran agricultural pest Helicoverpa armigera as a model, we revealed that 20-hydroxyecdysone (20E) binds to the…

Correction: Endogenous Retrovirus EAV-HP Linked to Blue Egg Phenotype in Mapuche Fowl

David Wragg; Joram M. Mwacharo; José A. Alcalde dkk.

PLoS ONE, Vol. 8 No. 8 · 2013 · Inggris · PLOS Scopus

Endogenous Retrovirus EAV-HP Linked to Blue Egg Phenotype in Mapuche Fowl

David Wragg; Joram M. Mwacharo; José A. Alcalde dkk.

PLoS ONE, Vol. 8 No. 8 · 2013 · Inggris · PLOS Scopus

Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan…

Glycometabolism regulates hepatitis C virus release

Tao Yu; Qiankun Yang; Fangling Tian dkk.

PLOS Pathogens, Vol. 17 No. 7 · 2021 · Inggris · PLOS Scopus

HCV cell-culture system uses hepatoma-derived cell lines for efficient virus propagation. Tumor cells cultured in glucose undergo active aerobic glycolysis, but switch to oxidative phosphorylation for energy production when cultured in galactose. Here, we investigated whether modulation of…

Noninvasive Assessment of Gene Transfer and Expression by In Vivo Functional and Morphologic Imaging in a Rabbit Tumor Model

Murali K. Ravoori; Lin Han; Sheela P. Singh dkk.

PLoS ONE, Vol. 8 No. 6 · 2013 · Inggris · PLOS Scopus

Purpose: To evaluate the importance of morphology in quantifying expression after in vivo gene transfer and to compare gene expression after intra-arterial (IA) and intra-tumoral (IT) delivery of adenovirus expressing a SSTR2-based reporter gene in a large animal tumor model. Materials and Methods…

Correction: Noninvasive Assessment of Gene Transfer and Expression by In Vivo Functional and Morphologic Imaging in a Rabbit Tumor Model

Murali K. Ravoori; Lin Han; Sheela P. Singh dkk.

PLoS ONE, Vol. 8 No. 10 · 2013 · Inggris · PLOS Scopus

Visualizing the Prostate Gland by MR Imaging in Young and Old Mice

Murali Ravoori; Jyoti Duggal; Mihai Gagea dkk.

PLoS ONE, Vol. 8 No. 3 · 2013 · Inggris · PLOS Scopus

Purpose: Prostate imaging requires optimization in young and old mouse models. We tested which MR sequences and field strengths best depict the prostate gland in young and old mice; and, whether prostate MR signal, size, and architecture change with age. Technique: Magnetic resonance imaging (MRI)…

Dependence of DCE-MRI biomarker values on analysis algorithm

Chaan S. Ng; Wei Wei; James A. Bankson dkk.

PLOS ONE, Vol. 10 No. 7 · 2015 · Inggris · PLOS Scopus

Background: Dynamic contrast-enhanced MRI (DCE-MRI) biomarkers have proven utility in tumors in evaluating microvascular perfusion and permeability, but it is unclear whether measurements made in different centers are comparable due to methodological differences. Purpose: To evaluate how commonly…

Polymorphisms in the Presumptive Promoter Region of the SLC2A9 Gene Are Associated with Gout in a Chinese Male Population

Changgui Li; Nan Chu; Binbin Wang dkk.

PLoS ONE, Vol. 7 No. 2 · 2012 · Inggris · PLOS Scopus

Background: Glucose transporter 9 (GLUT9) is a high-capacity/low-affinity urate transporter. To date, several recent genome-wide association studies (GWAS) and follow-up studies have identified genetic variants of SLC2A9 associated with urate concentrations and susceptibility to gout. We therefore…

Three Gorges Dam: Impact of Water Level Changes on the Density of Schistosome-Transmitting Snail Oncomelania hupensis in Dongting Lake Area, China

Jin-Yi Wu; Yi-Biao Zhou; Yue Chen dkk.

PLOS Neglected Tropical Diseases, Vol. 9 No. 6 · 2015 · Inggris · PLOS Scopus

Background: Schistosomiasis remains an important public health issue in China and worldwide. Oncomelania hupensis is the unique intermediate host of schistosoma japonicum, and its change influences the distribution of S. japonica. The Three Gorges Dam (TGD) has substantially changed the ecology and…

Tumor T 1 Relaxation Time for Assessing Response to Bevacizumab Anti-Angiogenic Therapy in a Mouse Ovarian Cancer Model

Murali K. Ravoori; Masato Nishimura; Sheela P. Singh dkk.

PLOS ONE, Vol. 10 No. 6 · 2015 · Inggris · PLOS Scopus

Purpose: To assess whether T1 relaxation time of tumors may be used to assess response to bevacizumab anti-angiogenic therapy. Procedures: 12 female nude mice bearing subcutaneous SKOV3ip1-LC ovarian tumors were administered bevacizumab (6.25ug/g, n=6) or PBS (control, n=6) therapy twice a week for…

Cyclophilin B control of lysine post-translational modifications of skin type I collagen

Masahiko Terajima; Yuki Taga; Wayne A. Cabral dkk.

PLOS Genetics, Vol. 15 No. 6 · 2019 · Inggris · PLOS Scopus

Covalent intermolecular cross-linking of collagen is essential for tissue stability. Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys) hydroxylation of type I collagen impacting…

Quantification of Mineralized Bone Response to Prostate Cancer by Noninvasive In Vivo μCT and Non-Destructive Ex Vivo μCT and DXA in a Mouse Model

Murali Ravoori; Aneta J. Czaplinska; Charles Sikes dkk.

PLoS ONE, Vol. 5 No. 3 · 2010 · Inggris · PLOS Scopus

Background: To compare nondestructive in vivo and ex vivo micro-computed tomography (μCT) and ex vivo dual-energy-X-ray-absorptiometry (DXA) in characterizing mineralized cortical and trabecular bone response to prostate cancer involving the skeleton in a mouse model. Methodology/Principal…