6 results for "Lin Geng"

Crosslinking-Induced Endocytosis of Acetylcholine Receptors by Quantum Dots

Chi Wai Lee; Hailong Zhang; Lin Geng et al.

PLoS ONE, Vol. 9 No. 2 · 2014 · English · PLOS Scopus

In a majority of patients with myasthenia gravis (MG), anti-acetylcholine receptor (AChR) antibodies target postsynaptic AChR clusters and thus compromise the membrane integrity of neuromuscular junctions (NMJs) and lead to muscle weakness. Antibody-induced endocytosis of AChRs in the postsynaptic…

Experimental and Theoretical Investigation of Crystallographic Orientation Dependence of Nanoscratching of Single Crystalline Copper

Yanquan Geng; Junjie Zhang; Yongda Yan et al.

PLOS ONE, Vol. 10 No. 7 · 2015 · English · PLOS Scopus

In the present work, we perform experiments and molecular dynamics simulations to elucidate the underlying deformation mechanisms of single crystalline copper under the load-controlled multi-passes nanoscratching using a triangular pyramidal probe. The correlation of microscopic deformation…

Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study

Lin Geng; Lilith K. Whittles; Borame L. Dickens et al.

PLOS Medicine, Vol. 22 No. 2 · 2025 · English · PLOS Scopus

Background: Gonorrhea is the second most common sexually transmitted disease notified in Singapore in 2023. Evidence suggests that the 4CMenB vaccine designed to protect against Neisseria meningitidis infection may offer partial cross-protection against gonorrhea. This generated interest in using…

Correction: Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study

Lin Geng; Lilith K. Whittles; Borame L. Dickens et al.

PLOS Medicine, Vol. 22 No. 4 · 2025 · English · PLOS Scopus

Transcriptome-Guided Functional Analyses Reveal Novel Biological Properties and Regulatory Hierarchy of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes Crucial for Maturation

Ellen Poon; Bin Yan; Shaohong Zhang et al.

PLoS ONE, Vol. 8 No. 10 · 2013 · English · PLOS Scopus

Abstract: Human (h) embryonic stem cells (ESC) represent an unlimited source of cardiomyocytes (CMs); however, these differentiated cells are immature. Thus far, gene profiling studies have been performed with non-purified or non-chamber specific CMs. Here we took a combinatorial approach of using…

Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes

Ji-Dong Fu; Stephanie N. Rushing; Deborah K. Lieu et al.

PLoS ONE, Vol. 6 No. 11 · 2011 · English · PLOS Scopus

Background: MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive. Methods and Results: We…