4 hasil untuk "Lin Yu"
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Artikel Jurnal Teks lengkap
Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
Abstract As a critical internal RNA modification in higher eukaryotes, N6-methyladenosine (m6A) has become the hotspot of epigenetics research in recent years. Extensive studies on messenger RNAs have revealed that m6A affects RNA fate and cell functions in various bioprocesses, such as RNA…
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Artikel Jurnal Teks lengkap
Rapid Detection of COVID-19 Coronavirus Using a Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) Diagnostic Platform
To the Editor: The recent outbreak of a novel coronavirus SARS-CoV-2 (also known as 2019-nCoV) threatens global health, raising serious cause for concern. It is urgent to develop rapid, accurate, and onsite diagnostic methods to effectively identify individuals with early infections, administer…
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Artikel Jurnal Teks lengkap
Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
Studies on biological functions of N6-methyladenosine (m6A) modification in mRNA have drawn significant attention in recent years. Here we describe the construction and characterization of a CRISPR-Cas13b-based tool for targeted demethylation of specific mRNA. A fusion protein, named dm6ACRISPR…
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Artikel Jurnal Teks lengkap
Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation of non-small cell lung cancer (NSCLC) via the…